Preventive (prophylactic) mastectomy: Surgery to reduce breast cancer risk

Prophylactic mastectomy may reduce your risk of breast cancer. Learn how doctors assess breast cancer risk and how prophylactic mastectomy may help prevent breast cancer.

By Mayo Clinic Staff

Finding out you're at high risk of breast cancer leads to difficult questions and decisions.

One such question is whether to have preventive mastectomy (prophylactic mastectomy) — surgery to remove one or both breasts in hopes of preventing or reducing your risk of breast cancer.

Keep in mind that being identified as having high risk doesn't mean you're certain to get breast cancer. All it means is that your likelihood of developing the disease is several times higher than that of women with average risk.

Understanding your individual level of risk can help you weigh your options for risk-reducing strategies, including prophylactic mastectomy.

Who may consider prophylactic mastectomy to reduce breast cancer risk?

All women are at risk of breast cancer just by being female and advancing in age. But some factors increase your risk significantly.

You may consider prophylactic mastectomy if you have:

  • Already had cancer in one breast. If you need to have one breast removed because of a new cancer diagnosis, and you have a hereditary breast cancer mutation, such as the BRCA1 or BRCA2 mutation, you may decide to have the other, unaffected breast removed at the same time. This prophylactic mastectomy would greatly reduce the possibility of another breast cancer in your lifetime.
  • A family history of breast cancer. If your mother, sister or daughter has had breast cancer, especially if she was diagnosed before age 50, you may be at increased risk. If you have multiple family members — on your mother's or father's side — with breast or ovarian cancer, your risk of breast cancer may be greater.
  • Positive results from gene testing. Genetic testing can identify mutations in genes, such as BRCA1 and BRCA2, that substantially increase your risk of breast or other cancers. If you have a very strong family history of breast cancer, such as relatives with young-onset cancer (younger than 50 years of age) over multiple generations, consider meeting with a genetic counselor to discuss genetic testing. Women of Ashkenazi Jewish descent have a higher incidence of the BRCA1 and BRCA2 mutations.
  • Radiation therapy. If you had radiation therapy to your chest between the ages of 10 and 30, you have an increased risk of developing breast cancer.

Your doctor determines whether you're at high risk of breast cancer based on your risk factors.

With whom should women at high risk discuss their options?

Deciding what to do with the knowledge that you are at high risk of breast cancer is a complex and time-consuming process. It's best if you can work with a team of health professionals that includes a genetic counselor to get a complete evaluation of your risk and take the time to understand all of your options.

Many breast centers are staffed with breast-health specialists, genetic counselors, breast surgeons and reconstructive surgeons who can collaborate with you. Second opinions are strongly recommended for women considering prophylactic mastectomy.

Making the decision whether to have prophylactic mastectomy is not urgent. Give yourself time to weigh all the pros and cons. You may want to discuss your concerns and feelings with a breast-health specialist and a psychologist.

How much does prophylactic mastectomy reduce the risk of breast cancer?

Prophylactic mastectomy can reduce the chances of developing breast cancer in women at high risk of the disease:

  • For women with the BRCA1 or BRCA2 mutation, prophylactic mastectomy reduces the risk of developing breast cancer by 90 to 95 percent.
  • For women who have already had breast cancer and also have a family history of the disease, prophylactic mastectomy can reduce the risk of developing cancer in the other breast by 90 to 95 percent.

However, studies indicate that prophylactic mastectomy of the unaffected breast (contralateral prophylactic mastectomy) has little or no effect on overall survival for women who have had breast cancer in one breast and do not have genetic mutations or hereditary risk factors.

Having a prophylactic mastectomy doesn't guarantee that you'll never develop breast cancer because all of your breast tissue can't be removed during the surgery. Sometimes breast tissue can be found in your chest, armpit or skin, above your collarbone, or on the upper part of your abdominal wall.

It is impossible for a surgeon to remove all of this breast tissue. Although the chances are slim, breast tissue remaining in your body can still develop breast cancer.

What are the risks?

As with any surgery, prophylactic mastectomy has potential complications, including:

  • Bleeding
  • Infection
  • Pain
  • Anxiety or disappointment about changes to your appearance
  • Complications arising from breast reconstruction
  • The need for multiple operations

Are there other options for reducing the risk of breast cancer?

If you're at high risk of breast cancer and you decide against prophylactic mastectomy, you have other options for early detection and risk reduction.


Estrogens are hormones produced in your body that can promote breast cancer development and growth. Medications that block the effects of estrogen or reduce estrogen production in your body can reduce your risk of breast cancer. The options include:

  • Tamoxifen for premenopausal or postmenopausal women
  • Raloxifene (Evista), for postmenopausal women
  • Exemestane (Aromasin), for postmenopausal women
  • Anastrozole (Arimidex), for postmenopausal women

Although these medications can reduce the risk of invasive breast cancer by about 50 percent, they carry a risk of side effects. Discuss the risks and benefits of these medications with your doctor, and together you can decide whether medication is right for you.

Other options

Other options for early detection and risk reduction include:

  • Breast cancer screening. Your doctor may suggest mammogram and MRI every year. Screening should also involve an annual clinical breast exam by your doctor and breast-awareness education to familiarize you with the normal consistency of your breast tissue.
  • Surgery to remove the ovaries (prophylactic oophorectomy). This procedure can reduce the risk of both breast and ovarian cancers. In women at high risk of breast cancer, prophylactic oophorectomy may reduce that risk by up to 50 percent if the procedure is done before age 50, when women are premenopausal.
  • Healthy lifestyle. Maintaining a healthy weight, exercising most days of the week, limiting alcohol use and avoiding hormone therapy during menopause may reduce the risk of breast cancer.

    Eating a healthy diet might decrease your risk of some types of cancer, as well as diabetes, heart disease and stroke.

    For example, women who eat a Mediterranean diet supplemented with extra-virgin olive oil and mixed nuts might have a reduced risk of breast cancer. The Mediterranean diet focuses mostly on plant-based foods, such as fruits and vegetables, whole grains, legumes, and nuts. People who follow the Mediterranean diet choose healthy fats, such as olive oil, over butter and eat fish instead of red meat.

Get the latest health information from Mayo Clinic’s experts.

Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health.

To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail.

Jan. 08, 2021 See more In-depth

See also

  1. Alternative and complementary medicine for metastatic breast cancer
  2. Atypical hyperplasia of the breast
  3. Breast cancer
  4. Breast cancer chemoprevention
  5. Breast Cancer Education Tool
  6. Common questions about breast cancer treatment
  7. Breast cancer radiation: Can it cause dry skin?
  8. Infographic: Breast Cancer Risk
  9. Breast cancer staging
  10. Breast cancer types
  11. Infographic: Breast Reconstruction Options
  12. Coping with pain after breast surgery
  13. Dragon Boats and Breast Cancer
  14. Ductal carcinoma in situ (DCIS)
  15. Enlarged breasts in men (gynecomastia)
  16. Gene expression profiling for breast cancer: What is it?
  17. Genetic Testing for Breast Cancer
  18. Genetic testing for breast cancer: Psychological and social impact
  19. Get the support you need when you have metastatic breast cancer
  20. Inflammatory breast cancer
  21. Invasive lobular carcinoma
  22. Metastatic breast cancer
  23. Lobular carcinoma in situ (LCIS)
  24. Male breast cancer
  25. Mastectomy
  26. Metastatic breast cancer: Should you get a second opinion?
  27. What is breast cancer? An expert explains
  28. Paget's disease of the breast
  29. Palliative care for metastatic breast cancer
  30. Palliative care: Who is it for?
  31. Paulas story A team approach to battling breast cancer
  32. Pink Sisters
  33. Prophylactic oophorectomy: Preventing cancer by surgically removing your ovaries
  34. Recurrent breast cancer
  35. Relationships and metastatic breast cancer
  36. The Long Race Beating Cancer
  37. Treatment options for metastatic breast cancer
  38. Weight Loss After Breast Cancer
  39. What is metastatic breast cancer?
  40. Working with your doctor when you have metastatic breast cancer: Interview with a Mayo Clinic expert.