/rss/research-newsFind news related to research at Mayo Clinic.en-USOrgan transplantation has transformed countless lives, offering hope to people with end-stage organ failure. But for many patients, the journey doesn't end with surgery. Lifelong anti-rejection medications protect transplanted organs, but they also can increase the risk of infection, cancer and other serious health complications. On the latest episode of "Tomorrow's Cure," host Lindsay Sievert explores a question researchers have pursued for decades: What if the immune system could be taught to accept a transplanted…https://newsnetwork.mayoclinic.org/?p=417212Wednesday, August 5, 2026Getty JACKSONVILLE, Fla. — Mayo Clinic researchers have developed an experimental drug with the help of artificial intelligence (AI) to target the "undruggable" PDZ-domain of GIPC1 protein that helps different types of cancer, including pancreatic cancer, to grow and resist treatment. In laboratory studies, the drug slowed tumor growth, improved survival and enhanced the effects of the chemotherapy drug gemcitabine. The findings, published in Cell Reports, also demonstrate how AI could help develop a small…https://newsnetwork.mayoclinic.org/?p=417235Wednesday, August 5, 2026ROCHESTER, Minn. — Mayo Clinic researchers have identified a protein that cancer cells use to shut down the body's immune response, a discovery that could help scientists develop new treatments that make cancer immunotherapies more effective. Published in the Journal of Clinical Investigation, the study identifies a previously unknown role for a protein called TRAILshort, which acts like an immune "off switch." The researchers found that TRAILshort prevents T cells — the immune system's primary…https://newsnetwork.mayoclinic.org/?p=417184Monday, August 3, 2026ROCHESTER, Minn. — A visit from a therapy animal may do more than lift spirits. A new study in Mayo Clinic Proceedings highlights how animal-assisted treatment can support inpatient stroke rehabilitation. Patients who interacted with therapy animals showed greater engagement in their treatment, increased physical activity and longer mobility compared with those who did not. The findings suggest a promising approach to addressing common barriers patients face with stroke recovery, including limited motivation, reduced energy,…https://newsnetwork.mayoclinic.org/?p=416772Monday, August 3, 2026SAO PAULO and ROCHESTER, Minn. — Mayo Clinic and Einstein Hospital Israelita today announced a milestone in their collaboration to advance responsible artificial intelligence (AI)-enabled healthcare innovation. Einstein's de-identified clinical data is now available through Mayo Clinic Platform's secure, privacy-preserving global healthcare innovation ecosystem. The collaboration strengthens South American representation in global health datasets and enables researchers and innovators to develop, validate, and scale AI-enabled solutions across a broader representation of patient populations. "Working with…https://newsnetwork.mayoclinic.org/?p=417152Thursday, July 30, 2026For years, some patients diagnosed with multiple sclerosis (MS) weren't getting better despite receiving the right treatments. The problem wasn't the therapy. It was the diagnosis.  A new episode of "Tomorrow's Cure" podcast explores how the discovery of myelin oligodendrocyte glycoprotein antibody-associated disease, or MOGAD, transformed the understanding of autoimmune neurologic disease. Once mistaken for MS, MOGAD is now recognized as a distinct condition with its own diagnostic criteria, treatment approaches and emerging therapies.  https://www.youtube.com/watch?v=SkqoRAtzL6g…https://newsnetwork.mayoclinic.org/?p=417119Wednesday, July 29, 2026Getty Images ROCHESTER, Minn. — A series of Mayo Clinic studies is helping reshape scientists' understanding of senescent, or "zombie," cells — aging cells that no longer divide but remain metabolically active and release inflammatory molecules that contribute to age-related diseases. Marissa Schafer, Ph.D. Published across Nature journals, the studies authored by scientists within the Robert and Arlene Kogod Center on Aging move the field beyond recognizing that senescent cells contribute to aging. Together, they…https://newsnetwork.mayoclinic.org/?p=417096Wednesday, July 29, 2026Microscopy image of the mitochondria network and staining of the histone acetylation. ROCHESTER, Minn. — Researchers have uncovered a previously unknown mechanism that helps aging cells drive the chronic inflammation linked to many age-related diseases. The findings reveal how dysfunctional mitochondria — the cell's energy-producing structures — work with the cell's epigenetic machinery to switch on inflammatory genes, opening the door to a new therapeutic approach for promoting healthier aging. The study, published in Nature,…https://newsnetwork.mayoclinic.org/?p=417123Wednesday, July 29, 2026PHOENIX — An international phase 3 study performed at all three Mayo Clinic destination medical centers found that a new immunotherapy helped many patients with an aggressive form of bladder cancer keep their bladder instead of having it surgically removed. The treatment also kept many patients cancer-free for more than two years and caused mostly mild side effects. The findings were published in The Lancet Oncology. Patients in the study had high-risk bladder cancer that…https://newsnetwork.mayoclinic.org/?p=417079Tuesday, July 28, 2026Brian Lundstrom, M.D., Ph.D., neurologist and physician-scientist at Mayo Clinic in Rochester, Minnesota The brain relies on carefully coordinated electrical signals to control everything from movement and memory to thought and emotion. When those signals become too active or poorly regulated, they can contribute to neurological disorders such as epilepsy. Researchers are working to better understand these abnormal patterns of brain activity and develop new ways to measure and safely influence them without surgery.  Brian…https://newsnetwork.mayoclinic.org/?p=416822Wednesday, July 22, 2026Decentralized approach increases participation among rural and underserved populations ROCHESTER, Minn. — A Mayo Clinic study published in JAMA Network Open found that bringing some or all clinical trial-related activities directly to patients can help overcome barriers that prevent many people from participating. Increased participation and expanded access to research was observed for people in rural communities and underserved populations. The study evaluated Mayo Clinic's decentralized clinical trials program, which allows many research activities to…https://newsnetwork.mayoclinic.org/?p=416731Monday, July 20, 2026Dr. Andres Acosta. Research identifies subtype of `hungry gut' obesity phenotype ROCHESTER, Minn. — Why do some people lose substantial weight with GLP-1-based medications while others see more modest results? A Mayo Clinic study offers a potential answer by identifying a distinct biological subtype of obesity that responds especially well to tirzepatide, a medication that mimics two naturally occurring hormones involved in appetite and blood sugar regulation, moving the field closer to precision medicine for…https://newsnetwork.mayoclinic.org/?p=416686Thursday, July 16, 2026Shutterstock ROCHESTER, Minn. — A major national cooperative group clinical trial led by Mayo Clinic researchers found that continuing maintenance therapy with lenalidomide beyond two years after initial treatment for standard-risk multiple myeloma did not improve overall survival compared with stopping treatment after two years. The findings, published in The New England Journal of Medicine, may help physicians and patients make more informed decisions about the duration of maintenance therapy. "Longer treatment is often assumed…https://newsnetwork.mayoclinic.org/?p=416638Wednesday, July 15, 2026Bile duct cancer, also called cholangiocarcinoma, is rare, difficult to diagnose and often resistant to existing treatments. This episode of "Tomorrow's Cure" explores why researchers are pursuing new approaches, including an experimental platform that uses milk-derived nanoparticles to deliver gene therapy directly to cancer cells.  In the episode, Rory Smoot, M.D., a hepatobiliary and pancreas surgeon at Mayo Clinic, explains that cholangiocarcinoma often develops without obvious symptoms until it reaches an advanced stage. Although researchers…https://newsnetwork.mayoclinic.org/?p=416627Wednesday, July 15, 2026Deployment across Mayo Clinic pathology practices integrates AI-enabled digital pathology with historical pathology images and clinical data in a unified workflow. ROCHESTER, Minn., and OREM, Utah — Mayo Clinic and Techcyte today announced the implementation of Anatomic Pathology (AP) technology, a next-generation digital pathology platform developed through a co-development and intellectual property licensing agreement between the two organizations. This collaboration expands adoption of Mayo Clinic Digital Pathology innovations while advancing development of a next-generation digital…https://newsnetwork.mayoclinic.org/?p=416632Wednesday, July 15, 2026Considered the most aggressive form of primary brain cancer in adults, glioblastoma represents a striking biological paradox: One of the brain's greatest threats can arise from the very cells designed to keep it healthy.  Glioblastoma begins in glial cells, the brain's support cells. When these cells become cancerous, they can grow rapidly into surrounding tissue, damaging the healthy brain they were meant to protect.  Watch: The Mayo Clinic Minute https://www.youtube.com/watch?v=DP7p09z_mOY Journalists: Broadcast-quality video (1:05) is…https://newsnetwork.mayoclinic.org/?p=416612Wednesday, July 15, 2026PHOENIX — Researchers at Mayo Clinic, in collaboration with the Terasaki Institute for Biomedical Innovation, have developed a real-time monitoring system designed to give transplant teams a more complete picture of a donor liver's health during machine perfusion. Published in Nature Communications, the study represents an important step toward more accurate evaluation of donor livers, laying the groundwork for future advances in organ preservation and transplantation. During machine perfusion, a donor liver is connected to…https://newsnetwork.mayoclinic.org/?p=416548Tuesday, July 14, 2026Mayo Clinic researchers are uncovering the earliest shifts in disease biology — long before symptoms appear — revealing how disease takes root and opening new possibilities to change its course.  By the time a disease is diagnosed, it may have been developing silently for years. Along the way, the body leaves clues: proteins shift, metabolism changes, immune responses evolve, and environmental exposures leave measurable traces. Until recently, many of these early signals were impossible to detect. Mayo Clinic…https://newsnetwork.mayoclinic.org/?p=416365Thursday, July 9, 2026A novel theranostics study explores imaging- and data-informed approaches to support individualized treatment decisions and expand access to theranostics Collaboration stems from a 2023 Strategic Radiology Research Alliance between Mayo Clinic and GE HealthCare, aimed at transforming the experience of patients and clinicians in the practice of radiology and the delivery of novel therapies CHICAGO, Ill. and ROCHESTER, Minn. — GE HealthCare and Mayo Clinic today announced the MI-BET (Molecular Imaging Biomarker-Based End of Therapy…https://newsnetwork.mayoclinic.org/?p=416368Wednesday, July 8, 2026ROCHESTER, Minn. — Researchers have validated a genetic scoring tool that may help physicians diagnose idiopathic pulmonary fibrosis and identify which patients are at greatest risk for severe outcomes, including death or the need for a lung transplant. The findings come from a new international study of more than 570,000 people co-led by Mayo Clinic and Brigham and Women's Hospital. Published in the American Journal of Respiratory and Critical Care Medicine, the study is one…https://newsnetwork.mayoclinic.org/?p=416383Tuesday, July 7, 2026