/rss/research-newsFind news related to research at Mayo Clinic.en-USMayo Clinic researchers are combining biological, environmental and health data with artificial intelligence to identify changes that may signal disease years before clinical symptoms appear  By the time doctors diagnose Alzheimer's disease, heart failure or cancer, the biological processes behind the illness may have been unfolding silently for years or even decades.  Mayo Clinic wants to make those invisible years a new target for medicine.  The healthcare organization is undertaking a sweeping research effort, called…https://newsnetwork.mayoclinic.org/?p=417775Monday, September 14, 2026ROCHESTER, Minn. — Mayo Clinic researchers tested an approach that uses artificial intelligence (AI) to help people without previous ultrasound experience capture heart images and identify patients who may have a common and serious heart valve condition. In a study published in JAMA Cardiology and presented at the 2026 ESC Congress, after four hours of training, novice users were able to collect focused heart ultrasound images while using  AI models to guide their image collection…https://newsnetwork.mayoclinic.org/?p=417632Wednesday, September 2, 2026ROCHESTER, Minn. — A liver disease affecting nearly 30% of adults worldwide is not a single illness but five biologically distinct subtypes, Mayo Clinic researchers have found. Each carries different risks for heart disease, liver failure, cancer and the need for liver transplantation. The study, published in Nature Communications and conducted in collaboration with scientists at Virginia Tech, shows that metabolic dysfunction-associated steatotic liver disease has multiple pathways — some tied to obesity and diabetes,…https://newsnetwork.mayoclinic.org/?p=414811Wednesday, September 2, 2026Helen Xiao, Ph.D., and Ruben Mars, Ph.D., work in the Mayo Clinic Microbiomics Program laboratory. ROCHESTER, Minn. — Mayo Clinic researchers have discovered that chemical signals produced by gut bacteria work together to control intestinal movement. One bacterial signal helps set the intestines in motion, while another primes gut cells to respond more strongly, amplifying the effect. The research expands scientists' understanding of how the gut microbiome communicates with the body, moving beyond the traditional…https://newsnetwork.mayoclinic.org/?p=417487Monday, August 31, 2026ROCHESTER, Minn. — Mayo Clinic researchers have estimated the risk that pancreatic cysts with worrisome or high-risk features will progress to pancreatic cancer or advanced precancerous changes within three years. The findings, published in Gastroenterology, could help physicians and patients better assess risk and make more informed decisions about whether to monitor a cyst or consider surgery.  The prospective study found that risk increased with the number of worrisome features, or findings that the cyst…https://newsnetwork.mayoclinic.org/?p=417415Thursday, August 20, 2026PHOENIX — Mayo Clinic researchers have developed and externally validated an artificial intelligence (AI) model that can identify a potentially significant heart obstruction from routine ultrasound videos without relying on specialized Doppler imaging. The technology could help clinicians flag patients with hypertrophic cardiomyopathy (HCM) who may need additional testing, particularly in settings where specialized echocardiography expertise is limited. Study findings are published in Circulation: Cardiovascular Imaging.   HCM is a genetic condition that causes the heart…https://newsnetwork.mayoclinic.org/?p=417409Wednesday, August 19, 2026ROCHESTER, Minn. — An international study led by Mayo Clinic researchers has identified interleukin-6 (IL-6) receptor blockers as a promising option for preventing relapses in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). MOGAD is a rare autoimmune neurological disorder that can cause vision loss, paralysis and other serious neurological complications. The study, published in JAMA Neurology, provides one of the largest real-world evaluations to date of IL-6 receptor blockade in patients with MOGAD and offers new…https://newsnetwork.mayoclinic.org/?p=417251Thursday, August 6, 2026Organ transplantation has transformed countless lives, offering hope to people with end-stage organ failure. But for many patients, the journey doesn't end with surgery. Lifelong anti-rejection medications protect transplanted organs, but they also can increase the risk of infection, cancer and other serious health complications. On the latest episode of "Tomorrow's Cure," host Lindsay Sievert explores a question researchers have pursued for decades: What if the immune system could be taught to accept a transplanted…https://newsnetwork.mayoclinic.org/?p=417212Wednesday, August 5, 2026Getty JACKSONVILLE, Fla. — Mayo Clinic researchers have developed an experimental drug with the help of artificial intelligence (AI) to target the "undruggable" PDZ-domain of GIPC1 protein that helps different types of cancer, including pancreatic cancer, to grow and resist treatment. In laboratory studies, the drug slowed tumor growth, improved survival and enhanced the effects of the chemotherapy drug gemcitabine. The findings, published in Cell Reports, also demonstrate how AI could help develop a small…https://newsnetwork.mayoclinic.org/?p=417235Wednesday, August 5, 2026ROCHESTER, Minn. — Mayo Clinic researchers have identified a protein that cancer cells use to shut down the body's immune response, a discovery that could help scientists develop new treatments that make cancer immunotherapies more effective. Published in the Journal of Clinical Investigation, the study identifies a previously unknown role for a protein called TRAILshort, which acts like an immune "off switch." The researchers found that TRAILshort prevents T cells — the immune system's primary…https://newsnetwork.mayoclinic.org/?p=417184Monday, August 3, 2026ROCHESTER, Minn. — A visit from a therapy animal may do more than lift spirits. A new study in Mayo Clinic Proceedings highlights how animal-assisted treatment can support inpatient stroke rehabilitation. Patients who interacted with therapy animals showed greater engagement in their treatment, increased physical activity and longer mobility compared with those who did not. The findings suggest a promising approach to addressing common barriers patients face with stroke recovery, including limited motivation, reduced energy,…https://newsnetwork.mayoclinic.org/?p=416772Monday, August 3, 2026SAO PAULO and ROCHESTER, Minn. — Mayo Clinic and Einstein Hospital Israelita today announced a milestone in their collaboration to advance responsible artificial intelligence (AI)-enabled healthcare innovation. Einstein's de-identified clinical data is now available through Mayo Clinic Platform's secure, privacy-preserving global healthcare innovation ecosystem. The collaboration strengthens South American representation in global health datasets and enables researchers and innovators to develop, validate, and scale AI-enabled solutions across a broader representation of patient populations. "Working with…https://newsnetwork.mayoclinic.org/?p=417152Thursday, July 30, 2026For years, some patients diagnosed with multiple sclerosis (MS) weren't getting better despite receiving the right treatments. The problem wasn't the therapy. It was the diagnosis.  A new episode of "Tomorrow's Cure" podcast explores how the discovery of myelin oligodendrocyte glycoprotein antibody-associated disease, or MOGAD, transformed the understanding of autoimmune neurologic disease. Once mistaken for MS, MOGAD is now recognized as a distinct condition with its own diagnostic criteria, treatment approaches and emerging therapies.  https://www.youtube.com/watch?v=SkqoRAtzL6g…https://newsnetwork.mayoclinic.org/?p=417119Wednesday, July 29, 2026Getty Images ROCHESTER, Minn. — A series of Mayo Clinic studies is helping reshape scientists' understanding of senescent, or "zombie," cells — aging cells that no longer divide but remain metabolically active and release inflammatory molecules that contribute to age-related diseases. Marissa Schafer, Ph.D. Published across Nature journals, the studies authored by scientists within the Robert and Arlene Kogod Center on Aging move the field beyond recognizing that senescent cells contribute to aging. Together, they…https://newsnetwork.mayoclinic.org/?p=417096Wednesday, July 29, 2026Microscopy image of the mitochondria network and staining of the histone acetylation. ROCHESTER, Minn. — Researchers have uncovered a previously unknown mechanism that helps aging cells drive the chronic inflammation linked to many age-related diseases. The findings reveal how dysfunctional mitochondria — the cell's energy-producing structures — work with the cell's epigenetic machinery to switch on inflammatory genes, opening the door to a new therapeutic approach for promoting healthier aging. The study, published in Nature,…https://newsnetwork.mayoclinic.org/?p=417123Wednesday, July 29, 2026PHOENIX — An international phase 3 study performed at all three Mayo Clinic destination medical centers found that a new immunotherapy helped many patients with an aggressive form of bladder cancer keep their bladder instead of having it surgically removed. The treatment also kept many patients cancer-free for more than two years and caused mostly mild side effects. The findings were published in The Lancet Oncology. Patients in the study had high-risk bladder cancer that…https://newsnetwork.mayoclinic.org/?p=417079Tuesday, July 28, 2026Brian Lundstrom, M.D., Ph.D., neurologist and physician-scientist at Mayo Clinic in Rochester, Minnesota The brain relies on carefully coordinated electrical signals to control everything from movement and memory to thought and emotion. When those signals become too active or poorly regulated, they can contribute to neurological disorders such as epilepsy. Researchers are working to better understand these abnormal patterns of brain activity and develop new ways to measure and safely influence them without surgery.  Brian…https://newsnetwork.mayoclinic.org/?p=416822Wednesday, July 22, 2026Decentralized approach increases participation among rural and underserved populations ROCHESTER, Minn. — A Mayo Clinic study published in JAMA Network Open found that bringing some or all clinical trial-related activities directly to patients can help overcome barriers that prevent many people from participating. Increased participation and expanded access to research was observed for people in rural communities and underserved populations. The study evaluated Mayo Clinic's decentralized clinical trials program, which allows many research activities to…https://newsnetwork.mayoclinic.org/?p=416731Monday, July 20, 2026Dr. Andres Acosta. Research identifies subtype of `hungry gut' obesity phenotype ROCHESTER, Minn. — Why do some people lose substantial weight with GLP-1-based medications while others see more modest results? A Mayo Clinic study offers a potential answer by identifying a distinct biological subtype of obesity that responds especially well to tirzepatide, a medication that mimics two naturally occurring hormones involved in appetite and blood sugar regulation, moving the field closer to precision medicine for…https://newsnetwork.mayoclinic.org/?p=416686Thursday, July 16, 2026Shutterstock ROCHESTER, Minn. — A major national cooperative group clinical trial led by Mayo Clinic researchers found that continuing maintenance therapy with lenalidomide beyond two years after initial treatment for standard-risk multiple myeloma did not improve overall survival compared with stopping treatment after two years. The findings, published in The New England Journal of Medicine, may help physicians and patients make more informed decisions about the duration of maintenance therapy. "Longer treatment is often assumed…https://newsnetwork.mayoclinic.org/?p=416638Wednesday, July 15, 2026