Psychiatry and Psychology

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study of Mood Symptoms in Epilepsy Patients

   Rochester, Minn.

   The purpose of this study is to track neuropsychiatric symptoms in patients with epilepsy.

2. A Study to Evaluate Women's Birth Experience and Postpartum Mental Health Outcomes

   Rochester, Minn.

   The purpose of this study is to implement a facilitated peer support group for women that have experienced an unexpected birth process in the last 12 months. 

3. Adolescent Biomarker Guided rTMS

   Rochester, Minn.

   The purpose of this study is to gather information regarding the use of rTMS as a treatment for depression in adolescents with Major Depressive Disorder. The investigators also hope to learn if measures of brain activity (cortical excitability and inhibition) collected with transcranial magnetic stimulation (TMS) can be used to identify which patients will benefit from certain types of rTMS treatment. 

4. A Study of Factors That Predispose, Promote, and Perpetuate Post-Traumatic Dizziness

   Rochester, Minn.

   The purpose of this study is to investigate whether recent, groundbreaking discoveries about key pathophysiologic processes that drive chronic dizziness in patients without traumatic brain injury (TBI9,10) are applicable to patients with post-mTBI vestibular disability. We expect the results of this project to have practical clinical and research applications, providing novel data for two future steps:

5. A Study to Research Epilepsy in Adolescent Clinical Transitions

   Rochester, Minn.

   The primary aims of this study are to 1) evaluate the acceptability of implementing a novel transition program for adolescents with epilepsy; 2) evaluate the needs of patients and their families as they prepare for transition from pediatric to adult care; and 3) improve transition readiness and outcomes in youths with epilepsy.

6. A Study to Determine Whether Ongoing Assessment Aids Treatment

   Rochester, Minn.

   The purposes of this study are to summarize clinician evaluations of the NNDC battery in the single clinic where the adult battery is currently being administered to adolescents, to determine patient and clinician level of interest in using the NNDC battery in clinics where the adult battery is not currently being administered to adolescent patients (n=14), to measure change in evaluation 3 months post-implementation for any sites that begin administering the NNDC battery to adolescents, and to generate potential new Child and Adolescent Mood Disorders Interest Group (CAMDIG) research protocols for future consideration.

7. A Study to Evaluate a Primary Care-Based Intervention for Adolescent Restrictive Eating Disorders

   Rochester, Minn.

   The purpose of this study is to assess the feasibility, acceptability, usability, and preliminary outcomes of a treatment protocol (FBT-PC) for PCP management of adolescent restrictive eating disorders.

8. Common Mechanisms of Anti-Suicidal Drug Action

   Rochester, Minn.

   The purpose of this study is to characterize the effects of clozapine, lithium, and ketamine on mTOR signaling, glucose uptake, and overall cellular metabolic function in peripheral blood mononuclear cells (PBMCs) from suicidal psychiatric inpatients.

9. Pharmacogenomics and Pharmacometabolomics of Acamprosate Treatment Outcome

   Rochester, Minn.

   The purpose of this study is to identify genetic and metabolomic biomarkers associated with acamprosate response in previously collected samples.

10. A Study to Evaluate the CAMS Relational Agent System (CAMS-RAS) for Suicide Prevention

    Rochester, Minn.

    The purpose of this study is a continuation of the Phase I feasibility study where the investigators fully met and exceeded project aims to design, build, and test the usability and acceptability of an avatar-based system, the Virtual-CAMS (V-CAMS, formerly called CAMS-RAS), for use by suicidal ED patients and medical personnel responsible for their care.

    Phase II includes a formative phase, during which the investigators will continue conducting usability and acceptability tests of new features, and a summative phase to conduct a clinical trial. SBIR Phase II project aims include: (1) Complete development of V-CAMS, including readiness for electronic health record integration; (2) Cultivate and utilize the advisory board so that V-CAMS is positioned to meet the needs of diverse healthcare systems and successful conduct of the proposed research; (3) Conduct usability/acceptability tests of new features with target end-users (suicidal patients, including those in the ED, medical providers) and key stakeholders (i.e., administrators); and (4) Conduct a randomized controlled trial (RCT; N=90) of suicidal ED patients comparing V-CAMS (n=45) to Care-As-Usual (CAU; n=45). Participants will be assessed at baseline while in the ED, and again at 7, 30, and 90 days. The investigators predict that V-CAMS participants will report a significantly greater decrease in suicidal behaviors and ED/hospital admissions, as well as significantly greater increases in use of behavioral coping skills, self-efficacy in coping with distress, and perceived helpfulness of patients' ED experience.