Mayo Clinic GeneGuide
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Mayo Clinic GeneGuide™
A genetic testing experience
that helps you understand
how genetics can affect
your health.
Order
A genetic testing experience
that helps you understand
how genetics can affect
your health.
Order
A genetic testing experience
that helps you understand
how genetics can affect
your health.
Order
A genetic testing experience
that helps you understand
how genetics can affect
your health.
Order
More than a genetic test.
Your genes tell a fascinating story about your health and potential risk of certain diseases and conditions.
  • Dive into friendly education
  • Explore your genetic testing results
  • Receive feedback from the interactive tools
  • Build valuable knowledge
Not available in Md., N.J., N.Y., Pa. or R.I.
Our affiliated physicians at PWNHealth will help determine if this product is right for you. Genetic counselor support is available from
PWNHealth throughout the testing experience. Learn more about this process.
1
How it works
What your
genes can
tell you.
Your Mayo Clinic GeneGuide™ genetic test results include laboratory genetic test reports in these categories.
2
How it works
Your
results.
Mayo Clinic GeneGuide™ reports are confidential and easy to understand. You're in control. You can easily download and share your reports with family or health care providers should you choose to.

*Example results shown on right.
Interactive features help visualize potential health risks.
increasing risk for CAD Cigar e t t e s B l o o d P r e ssu r e H D L C h o l e s t e r o l Age Female rs4977574
3
How it works
Exploration.
Discovery.
Power.
Robust education. Interactive tools. Genetic test results fully explained. The tools you need to explore your genes and understand your genetic test results are at your fingertips.
4
How it works
Education from Mayo Clinic experts.
Integrated education provides answers to your questions about genetics and your health.
Interactive tools help you explore your personal lifestyle, family history and ethnicity.
Carrier Screening
Discover if you silently carry genetic variants that could affect your children or other family members.  More
Disease Risk
Learn if you have genetic variants that may increase your risk of a disease or condition.  More
Medication Response
Understand how your genes might affect your response to certain medications.  More
Health Traits
Discover how genes might impact your digestion metabolism or other physical characteristics.  More
Interactive features help visualize potential health risks.
increasing risk for CAD Cigar e t t e s B l o o d P r e ssu r e H D L C h o l e s t e r o l Age Female rs4977574
Lifestyle Risk Assessment
Learn how your habits and environment affect your health.  More
Hereditary Breast Cancer Risk Screening Tool
Find out if it would be advisable to seek genetic counseling for hereditary breast and ovarian cancer risks.  More
Pedigree
Capture and document your family's medical history.  More
Health Ancestry
Discover how your ethnic background may increase your risk of inherited conditions.  More

Features

Genetic Results Information

Carrier Screening
Cystic Fibrosis
Cystic fibrosis (CF) is a condition that can cause damage to the respiratory (lungs) system and affect the function of the digestive (stomach, intestines, pancreas) and reproductive systems (sex organs). CF also affects the cells that produce mucus, sweat and digestive fluids.
GJB2-Related Hearing Loss
Changes in the GJB2 gene are the most common cause of hereditary hearing loss. GJB2-related hearing loss is typically present at birth, is slowly progressive, and can be mild to severe.
MCAD Deficiency
Medium-chain acyl-CoA dehydrogenase deficiency is an inherited disorder that affects the body's ability to break down certain fats and convert them into energy. Symptoms typically appear in babies and young children. If diagnosed and treated early, the disorder can be managed through diet and lifestyle actions. In rare cases, diagnosis does not occur until adulthood. Left untreated, it can lead to seizures, breathing difficulties, coma and other serious health problems.
Sickle Cell Disease
Sickle cell disease is a condition in which normal red blood cells, which are flexible and round, become stiff and sickle-shaped. Normal red blood cells carry oxygen to the body’s tissues. Sickle cells have a much shorter lifespan than normal red blood cells, causing chronic shortage of red blood cells in the body, called anemia. Symptoms include pain episodes, swelling of the hands/feet, frequent infections, delayed growth and vision issues.
Disease Risk
Age-Related Macular Degeneration (ARMD)
Age-related macular degeneration (ARMD) is a common eye condition in people over the age of 50. ARMD causes blurred central vision or a blind spot in the center of the visual field. It does not lead to complete loss of vision.
Atrial Fibrillation
Atrial fibrillation is an irregular and often rapid heart rate. It can increase a person’s risk of stroke, heart failure and other heart-related complications. It can also lead to blood clots forming in the heart that may travel to other organs and block blood flow.
Coronary Artery Disease (CAD)
Coronary artery disease is the major cause of heart attacks, which occur when the blood vessels that bring oxygen to the heart are blocked. Signs and symptoms include shortness of breath, chest pain and heart attack.
Venous Thromboembolism
Venous thromboembolism is a condition in which one or more abnormal blood clots form in a vein. These clots can cause medical complications and may even be life-threatening.
Medication Response
Ibuprofen Metabolism
Ibuprofen is an over-the-counter medication commonly used to relieve pain and inflammation. It is available under a variety of brand names, including Advil, Motrin and others. Variants in the CYP2C9 gene can affect how the body breaks down (metabolizes) ibuprofen. Some variants decrease ibuprofen metabolism, causing the medication to build up in the body over time, which may increase the risk of side effects.
Malignant Hyperthermia Susceptibility
Malignant hyperthermia is a condition that can cause a severe reaction to anesthesia. Signs and symptoms of malignant hyperthermia include a dangerously high body temperature, severe muscle spasms and a fast heart rate after exposure to anesthesia. Prompt medical response to any severe anesthesia reaction is critical.
Omeprazole Metabolism
Omeprazole is a medication most often used to treat conditions where there is too much acid in the stomach. It's available by prescription or over-the-counter (OTC) under a variety of brand names including Prilosec and Prilosec OTC. Variants in the CYP2C19 gene can affect how the body breaks down (metabolizes) omeprazole which can impact risk for side effects or effectiveness of the medication.
Pseudocholinesterase Deficiency
Pseudocholinesterase deficiency is a condition that makes a person sensitive to anesthesia. Both genetic variants and non-genetic factors associated with this condition can cause the muscles to stay relaxed longer than expected; this can prevent a person from moving or breathing on their own for longer than expected after surgery.
Health Traits
Alcohol Flush Reaction
Alcohol flush is a genetic trait that interferes with the body’s ability to break down alcohol. When people with this trait drink alcohol, they experience facial redness, rapid heartbeat, nausea, and low blood pressure. In addition to causing alcohol flush, people with the trait have an increased risk of cancer of the esophagus.
Atopic Dermatitis
Atopic dermatitis (eczema) is a condition that causes the skin to become red, itchy and prone to rashes.
Lactase Persistence
Lactase persistence is a genetic trait that affects the body’s ability to digest dairy products. Lactase is an enzyme that helps digest the sugar found in milk (lactose). People with lactase persistence can easily digest milk products throughout their lifetime. Those who do not have lactase persistence, known as lactose intolerance, may experience bloating and abdominal pain, nausea, gas and diarrhea.

Tools

Tools

Health Ancestry

Hereditary Breast Cancer Risk Screening Tool (not a genetic test)

Lifestyle Risk Assessment

Pedigree

Education

Education Topics

About Mayo Clinic GeneGuide™

Genetic Fundamentals

Heredity and Family

Precision Medicine

Common Familial Diseases

Genetic Conditions

Glossary

Our affiliated physicians at PWNHealth will help determine if this product is right for you. Genetic counselor support is available from PWNHealth throughout the testing experience.

Mayo Clinic GeneGuide Process

  • 1
    PWNHEALTH
    Mayo Clinic GeneGuide™ affiliate, PWNHealth, ensures this product is right for you.
    Online physician test order
  • 2
    HELIX
    Sequences your DNA
    Our partner Helix, as the testing laboratory, provides next-generation sequencing (NGS) of your DNA sample.
  • 3
    MAYO CLINIC GENEGUIDE™
    Interprets your genetic test results
    Your results are reviewed and interpreted by Mayo Clinic's expert genetic professionals.

Through our seamless process your order begins with a review of your health history and test order from PWNHealth. Your Helix saliva collection kit ships within two days. Once Helix receives your saliva sample, Helix begins sequencing your DNA.

Your genetic test results are available through Mayo Clinic GeneGuide™ within six to eight weeks.

Featuring a Mayo Clinic patient who used genetic testing to gain insights into his potential health risks.
“I was surprised to find out that I may be at increased risk of something called malignant hyperthermia susceptibility.”
privacy
Your genes. Your privacy.

Mayo Clinic GeneGuide™ makes sure you are always in control of your genetic information.

Mayo Clinic is committed to the highest standards in ethics, confidentiality and data security.

Genetic testing experience
from Mayo Clinic and Helix
Mayo Clinic Logo
Mayo Clinic is a nonprofit organization committed to providing expert, whole-person care to everyone who needs healing. For more information, visit www.MayoClinic.org/about-Mayo-Clinic or http://newsnetwork.MayoClinic.org/.
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Mayo Clinic GeneGuide™ is powered by Helix. With Helix, simply sequence your DNA once and shop for a variety of products tailored to you. Find Mayo Clinic GeneGuide™ and more in the Helix Store.