Rochester, Minnesota, has many affordable housing options, including single-family and multifamily homes and apartment rentals. Housing costs vary depending on the accommodations. Some employees share apartments or rent out rooms, reducing their rent.

Many apartments and homes are located within walking distance to the Mayo Clinic campus and downtown amenities, as well as along city bus routes. Rochester Public Transit operates dozens of city bus routes, making it easy to commute to Mayo if you live outside of the downtown Rochester area, and commuter buses are available for employees living in the many communities surrounding Rochester.