What types of side effects do monoclonal antibody drugs cause?

Monoclonal antibody treatment for cancer can cause side effects, some of which, though rare, can be very serious. Talk to your health care provider about what side effects are associated with the particular drug you're receiving. Balance the potential side effects with the expected benefits to determine whether this is the right treatment for you.

Common side effects

In general, the more common side effects caused by monoclonal antibody drugs include:

• Allergic reactions, such as hives or itching
• Flu-like signs and symptoms, including chills, fatigue, fever, and muscle aches and pains
• Nausea, vomiting
• Diarrhea
• Skin rashes
• Low blood pressure

Serious side effects

Serious, but rare, side effects of monoclonal antibody therapy may include:

• Infusion reactions. Severe allergy-like reactions can occur and, very rarely, lead to death. You may receive medicine to block an allergic reaction before you begin monoclonal antibody treatment. Infusion reactions usually occur while treatment is being administered or soon after, so your health care team will watch you closely for a reaction. You might need to stay at the treatment facility for a few hours for monitoring.
• Heart problems. Certain monoclonal antibodies increase the risk of high blood pressure, congestive heart failure and heart attacks.
• Lung problems. Some monoclonal antibodies are associated with a higher risk of inflammatory lung disease.
• Skin problems. Sores and rashes on your skin can lead to serious infections in some cases. Serious sores can also occur on the tissue that lines your cheeks and gums (mucosa).
• Bleeding. Some monoclonal antibody drugs carry a risk of internal bleeding.