Capsaicin

Other topical treatments recommended for knee and hand osteoarthritis are those that have capsaicin (kap-SAY-ih-sin). Capsaicin causes the burning feeling that comes from chili peppers.

Examples include Capzasin-HP and Zostrix. Capsaicin blocks a chemical in the nerve cells that sends pain messages. Capsaicin works best when used several times a day. It might take up to two weeks to feel relief.