When not to use ACE inhibitors

Do not take ACE inhibitors with any of the following medicines:

• Angiotensin receptor blockers, also called ARBs
• Angiotensin receptor neprilysin inhibitors.
• Direct renin inhibitors.

Do not take an ACE inhibitor if you are pregnant. The medicines have been linked to birth defects in babies. If you're pregnant or plan to become pregnant, ask your healthcare professional about other options to treat high blood pressure.

Nonsteroidal anti-inflammatory drugs, also called NSAIDs, decrease how well ACE inhibitors work. Examples of NSAIDs are ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve).