Are there concerns about orlistat?

The FDA published a safety review of orlistat in 2010 because of rare reports of serious liver injury in people using it. The FDA found no evidence to confirm that orlistat was the cause of the reported liver injuries.

However, Alli and Xenical labels were revised because of the reports. Talk to your health care provider right away if you have signs or symptoms of liver injury, such as:

• Itching
• Loss of appetite
• Yellow eyes or skin
• Light-colored stool
• Brown urine