When variant(s) are found in more than one gene, the increased risk is not additive.

One variant in the F5 gene and one variant in the F2 gene found: Lifestyle factors increasing your risk for VTE (Not additive)

This test found one variant in the F5 (factor V) gene and one variant in the F2 (prothrombin-related) gene. View the list of genetic variants we test and found. Having one variant in the F5 gene increases your risk for a harmful blood clot. The risk is 3 to 5 times more than having zero variants. Having one variant in the F2 gene also increases your risk for a harmful blood clot. That risk is 2 to 3 times more than having zero variants. When variants are found in more than one gene, the increased risks cannot be added together for a compiled risk. There is little known about the actual risks of developing harmful blood clots with this rare combination of genetic variants. Talk to your family members about their chances of having a genetic variant in the F5 and/or F2 gene, too. How do I talk with my family? Around 1 in 1,000 people in the United States and Europe have one factor V and one prothrombin genetic variant.