Espina bífida

Por el personal de Mayo Clinic
16 de septiembre de 2026

Investigación

Expertos de Mayo Clinic participan en investigaciones para encontrar las causas de los trastornos neurológicos pediátricos, incluida la espina bífida. También realizan investigaciones para ayudar a desarrollar tratamientos nuevos y mejorados. Estas incluyen estudios sobre el desarrollo de niños con espina bífida a quienes les hicieron una cirugía antes de nacer en comparación con aquellos que fueron operados después de nacer.

Expertos que se especializan en medicina física y rehabilitación, incluida la rehabilitación pediátrica, centran sus investigaciones en hacer que las personas con discapacidades puedan realizar sus actividades cotidianas. Hay estudios en curso para investigar una manera de medir las patadas y el movimiento de las piernas en bebés con espina bífida con el fin de ayudar a diseñar intervenciones novedosas.

Publicaciones

Consulte la lista de publicaciones de los médicos de Mayo Clinic sobre la espina bífida en PubMed, un servicio de la Biblioteca Nacional de Medicina.

  1. What is spina bifida? Centers for Disease Control and Prevention. https://www.cdc.gov/ncbddd/spinabifida/facts.html. Accessed Oct. 4, 2023.
  2. Spina bifida. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/health-information/disorders/spina-bifida#. Accessed Oct. 4, 2023.
  3. Spina bifida. Merck Manual Professional Version. https://www.merckmanuals.com/professional/pediatrics/congenital-neurologic-anomalies/spina-bifida?query=spina%20bifida#. Accessed Oct. 4, 2023.
  4. Ferri FF. Spina bifida. In: Ferri's Clinical Advisor 2024. Elsevier; 2024. https://www.clinicalkey.com. Accessed Oct. 4, 2023.
  5. Bowman RM. Myelomeningocele (spina bifida): Anatomy, clinical manifestations and complications. https://www.uptodate.com/contents/search. Accessed Oct. 4, 2023.
  6. MAFP1 alpha-fetoprotein (AFP), single marker screen, maternal, serum. Mayo Medical Laboratories. https://www.mayocliniclabs.com/test-catalog/Overview/113382#Clinical-and-Interpretive. Accessed Oct. 4, 2023.
  7. Holcomb GW III, et al., eds. Neurosurgical conditions. In: Holcomb and Ashcraft's Pediatric Surgery. 7th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Oct. 4, 2023.
  8. Gleason CA, et al., eds. Congenital malformations of the central nervous system. In: Avery's Diseases of the Newborn. 11th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Oct. 4, 2023.
  9. Bowman RM. Myelomeningocele (spina bifida): Management and outcome. https://www.uptodate.com/contents/search. Accessed Oct. 4, 2023.
  10. Dietary supplement fact sheet: Folate. Office of Dietary Supplements. https://ods.od.nih.gov/factsheets/folate-HealthProfessional/. Accessed Oct. 4, 2023.
  11. Paslaru FG, et al. Myelomeningocele surgery over the 10 years following the MOMS trial: A systematic review of outcomes in prenatal versus postnatal surgical repair. Medicina. 2021; doi:10.3390/medicina57070707.
  12. Rocque BG, et al. Caring for the child with spina bifida. Pediatric Clinics of North America. 2021; doi:10.1016/j.pcl.2021.04.013.
  13. Schindelmann KH, et al. Systematic classification of spina bifida. Journal of Neuropathology and Experimental Neurology. 2021; doi:10.1093/jnen/nlab007.
  14. Ami TR. Allscripts EPSi. Mayo Clinic. Sept. 4, 2023.
  15. Wilson PE, et al. Mobility guidelines for the care of people with spina bifida. Journal of Pediatric Rehabilitation Medicine. 2020; doi:10.3233/PRM-200744.
  16. Viswanathan M, et al. Folic acid supplementation to prevent neural tube defects: Updated evidence report and systematic review for the U.S. Preventive Services Task Force. JAMA. 2023; doi:10.1001/jama.2023.9864.
  17. Data and statistics on spina bifida. Centers for Disease Control and Prevention. https://www.cdc.gov/ncbddd/spinabifida/data.html. Accessed Oct. 13, 2023.
  18. Kancherla V. Neural tube defects: A review of global prevalence, causes and primary prevention. Child's Nervous System. 2023; doi:10.1007/s00381-023-05910-7.
  19. Koch VH, et al. Multidisciplinary management of people with spina bifida across the lifespan. Pediatric Nephrology. 2023; doi:10.1007/s00467-023-06067-w.
  20. Dukhovny S, et al. Neural tube defects: Overview of prenatal screening, evaluation and pregnancy management. https://www.uptodate.com/contents/search. Accessed Oct. 4, 2023.
  21. Lee SY, et al. Fetal repair of neural tube defects. Clinics in Perinatology. 2022; doi:10.1016/j.clp.2022.06.004.
  22. Hydrocephalus and shunts. Spina Bifida Association. https://www.spinabifidaassociation.org/resource/hydrocephalus-and-shunts/. Accessed Oct. 10, 2023.
  23. Health issues and treatments for spina bifida. Centers for Disease Control and Prevention. https://www.cdc.gov/ncbddd/spinabifida/treatment.html. Accessed Oct. 10, 2023.
  24. Natural rubber latex allergy. Spina Bifida Association. https://www.spinabifidaassociation.org/resource/latex-2/. Accessed Oct. 10, 2023.
  25. Barry MJ, et al. Folic acid supplementation to prevent neural tube defects: U.S. Preventative Services Task Force reaffirmation recommendation statement. JAMA. 2023; doi:10.1001/jama.2023.12876.
  26. Infants and children. Spina Bifida Association. https://www.spinabifidaassociation.org/infants-children/. Accessed Oct. 12, 2023.
  27. Kritikos TK, et al. Mental health guidelines for the care of people with spina bifida. Journal of Pediatric Medicine. 202; doi:10.3233/PRM-200719.
  28. Palomaki GE, et al. Laboratory screening and diagnosis of open neural tube defects, 2019 revision: A technical standard of the American College of Medical Genetics and Genomics (ACMG). Genetics in Medicine. 2020: doi:10.1038/s41436-019-0681-0.
  29. Narang K, et al. Obstetric outcomes after fetal intervention — A single-center descriptive review. Journal of Maternal-Fetal and Neonatal Medicine. 2022; doi:10.1080/14767058.2021.1943658.