Infección con C. difficile

Por el personal de Mayo Clinic
23 de septiembre de 2026

Investigación

Los investigadores de Mayo Clinic participan en estudios que evalúan la epidemiología, los factores de riesgo y el tratamiento de la infección por C. difficile. Se están llevando a cabo estudios para caracterizar la composición microbiana fecal en el colon con el fin de desarrollar métodos que puedan predecir la respuesta al tratamiento y el riesgo de infección recurrente.

La División de Gastroenterología y Hepatología de Mayo Clinic tiene clínicas dedicadas a la investigación y al tratamiento de la infección por C. difficile, que incluyen estudios de la microflora intestinal y nuevas terapias para la infección por C. difficile. El Programa para Microbioma de Mayo Clinic está estudiando actualmente cómo la variación natural en el microbioma intestinal individual se relaciona con los factores de riesgo y la susceptibilidad a las infecciones por C. difficile.

Publicaciones

Consulte en PubMed una lista de publicaciones sobre la infección por C. difficile. escritas por los médicos de Mayo Clinic. PubMed es un servicio de la National Library of Medicine (Biblioteca Nacional de Medicina).

  1. Clostridioides (formerly Clostridium) difficile-induced diarrhea. Merck Manual Professional Version https://www.merckmanuals.com/professional/infectious-diseases/anaerobic-bacteria/clostridioides-formerly-clostridium-difficile%E2%80%93induced-diarrhea?. Accessed March 21, 2023.
  2. Lamont JT, et al. Clostridium difficile in adults: Epidemiology, microbiology, and pathophysiology. https://www.uptodate.com/contents/search. Accessed March 21, 2023.
  3. Frequently asked questions about Clostridium difficile for healthcare providers. Centers for Disease Control and Prevention. https://www.cdc.gov/cdiff/clinicians/faq.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fhai%2Forganisms%2Fcdiff%2Fcdiff_faqs_hcp.html. Accessed March 21, 2023.
  4. Guh AY, et al. Trends in U.S. burden of Clostridioides difficile infection and outcomes. New England Journal of Medicine. 2020; doi:10.1056/NEJMoa1910215.
  5. Lamont T, et al. Clostridium difficile in adults: Clinical manifestations and diagnosis. https://www.uptodate.com/contents/search. Accessed March 21, 2023.
  6. Loscalzo J, et al., eds. Clostridium difficile infection, including pseudomembranous colitis. In: Harrison's Principles of Internal Medicine. 21st ed. McGraw Hill; 2022. https://accessmedicine.mhmedical.com. Accessed March 21, 2023.
  7. McDonald LC, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (ISDA) and Society for Healthcare Epidemiology of America (SHEA). Clinical Infectious Diseases. 2018;66:987.
  8. AskMayoExpert. Clostridium difficile infection (adult). Mayo Clinic; 2022.
  9. Kelly CP, et al. Clostridium difficile in adults: Treatment. https://www.uptodate.com/contents/search. Accessed March 21, 2023.
  10. Saleh MM, et al. Colitis-induced TH17 cells increase the risk for severe subsequent Clostridium difficile infection. Cell Host and Microbe. 2019;25:756.
  11. Taur Y, et al. Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant. Science Translational Medicine. 2018;10:9489.
  12. Diet strategies for managing chronic diarrhea. International Foundation for Gastrointestinal Disorders. https://iffgd.org/gi-disorders/diarrhea/nutrition-strategies/. March 22, 2023.
  13. Tariq R, et al. Experience and outcomes at a specialized Clostridium difficile clinical practice. Mayo Clinic Proceedings Innovations Quality and Outcomes. 2017;1:49.
  14. Khanna S, et al. Current and future trends in clostridioides (clostridium) difficile infection management. Anaerobe. 2019; doi:10.1016/j.anaerobe.2019.04.010.
  15. Feldman M, et al., eds. Antibiotic-associated diarrhea and Clostridioides difficile infection. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 11th ed. Elsevier; 2021. https://www.clinicalkey.com. Accessed May 25, 2021.
  16. Johnson S, et al. Clinical practice guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 focused update guidelines on management of Clostridioides difficile infection in adults. Clinical Infectious Diseases. 2021; doi:10.1093/cid/ciab549.