Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

  1. Perseris
  2. Risperdal Consta
  3. Rykindo
  4. Uzedy

Descriptions


Risperidone injection is used to treat the symptoms of psychotic (mental) disorders, including schizophrenia. Risperdal Consta® may be used alone or together with other medicines (eg, lithium or valproate) to treat patients with bipolar disorder. This medicine should not be used to treat behavioral problems in older adults who have dementia.

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

  • Suspension, Extended Release
  • Powder for Suspension, Extended Release

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of risperidone injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Elderly patients may be especially sensitive to the effects of risperidone. This may increase the chance of having side effects during treatment. This medicine should not be used for behavioral problems in older adults with dementia.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of risperidone injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving risperidone injection.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bepridil
  • Bromopride
  • Cisapride
  • Dronedarone
  • Levoketoconazole
  • Levomethadyl
  • Mesoridazine
  • Metoclopramide
  • Pimozide
  • Piperaquine
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abiraterone Acetate
  • Acecainide
  • Adagrasib
  • Ajmaline
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Anagrelide
  • Apalutamide
  • Apomorphine
  • Apomorphine Hydrochloride
  • Aprindine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Atazanavir
  • Azimilide
  • Azithromycin
  • Bretylium
  • Bromocriptine Mesylate
  • Buprenorphine
  • Bupropion
  • Buserelin
  • Carbamazepine
  • Ceritinib
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clothiapine
  • Clozapine
  • Crizotinib
  • Dabrafenib
  • Darunavir
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexmedetomidine
  • Dexmethylphenidate
  • Dibenzepin
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Droperidol
  • Duloxetine
  • Efavirenz
  • Encainide
  • Encorafenib
  • Enflurane
  • Entrectinib
  • Enzalutamide
  • Erythromycin
  • Escitalopram
  • Etrasimod
  • Fedratinib
  • Fenoldopam Mesylate
  • Fexinidazole
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Formoterol
  • Foscarnet
  • Fosphenytoin
  • Fostemsavir
  • Gemifloxacin
  • Gepirone
  • Ginkgo Biloba
  • Glasdegib
  • Gonadorelin
  • Goserelin
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Imipramine
  • Inotuzumab Ozogamicin
  • Itraconazole
  • Ivabradine
  • Ivosidenib
  • Ketoconazole
  • Lefamulin
  • Lenvatinib
  • Leuprolide
  • Levofloxacin
  • Linezolid
  • Lithium
  • Lofexidine
  • Lorcainide
  • Lumacaftor
  • Macimorelin
  • Mefloquine
  • Methylphenidate
  • Metronidazole
  • Mirtazapine
  • Mitotane
  • Mobocertinib
  • Moxifloxacin
  • Nafarelin
  • Nilotinib
  • Nortriptyline
  • Octreotide
  • Olanzapine
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Ozanimod
  • Pacritinib
  • Panobinostat
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Phenobarbital
  • Phenytoin
  • Pimavanserin
  • Pitolisant
  • Ponesimod
  • Posaconazole
  • Pramipexole Dihydrochloride
  • Primidone
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quizartinib
  • Relugolix
  • Remifentanil
  • Ribociclib
  • Rifampin
  • Rifapentine
  • Ropinirole Hydrochloride
  • Rotigotine
  • Selpercatinib
  • Sematilide
  • Serdexmethylphenidate
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Simvastatin
  • Siponimod
  • Solifenacin
  • Sotalol
  • Spiramycin
  • St John's Wort
  • Sulfamethoxazole
  • Sulpiride
  • Sultopride
  • Sunitinib
  • Tacrolimus
  • Tedisamil
  • Telithromycin
  • Terbinafine
  • Tetrabenazine
  • Trazodone
  • Triclabendazole
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vilanterol
  • Vinflunine
  • Voclosporin
  • Zotepine
  • Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cimetidine
  • Lamotrigine
  • Midodrine
  • Ranitidine
  • Ritonavir
  • Valproic Acid

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergic reaction to paliperidone (Invega®), history of—Should not be used in patients with this condition.
  • Alzheimer's disease or
  • Dehydration or
  • Heart attack, recent or history of or
  • Heart or blood vessel disease or
  • Heart failure, history of or
  • Heart rhythm problem, or a history of or
  • Hypotension (low blood pressure) or
  • Hypovolemia (low amount of blood) or
  • Stroke, history of or
  • Trouble with swallowing—May cause side effects to become worse.
  • Blood or bone marrow problems or
  • Bone problems (eg, osteodystrophy) or
  • Breast cancer, prolactin-dependent or
  • Diabetes or
  • Hyperglycemia (high blood sugar) or
  • Hyperprolactinemia (high prolactin in the blood) or
  • Neuroleptic malignant syndrome (NMS), history of or
  • Parkinson's disease or
  • Priapism (painful or prolonged erection of the penis) or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use

A nurse or other trained health professional will give you this medicine. It is given as a shot into one of your muscles or as shot under your skin (in the stomach area or upper arm only).

Perseris™ is given once a month. Risperdal Consta® is usually given every 2 weeks. Uzedy™ is given once a month or once every 2 months.

If you have never taken risperidone, your doctor will first give you an oral form of this medicine before starting treatment with Perseris™, Risperdal Consta®, or Uzedy™.

Missed Dose

This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.

Be sure to keep all appointments for the injections.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine may increase risk for stroke in elderly patients with dementia. Tell your doctor right away if you have confusion, difficulty in speaking, slow speech, inability to speak, inability to move the arms, legs, or facial muscles, double vision, or headache while using this medicine.

Check with your doctor right away if you have difficulty with breathing, fast heartbeat, high fever, high or low blood pressure, increased sweating, loss of bladder control, seizures, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you have lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.

This medicine may increase the amount of sugar in your blood. Check with your doctor right away if you have blurred vision, dry mouth, flushed, dry skin, increased hunger, increased thirst or increased urination, nausea, sweating, trouble breathing, unexplained weight loss, unusual tiredness or weakness, or vomiting. If you have diabetes, you may notice a change in the results of your urine or blood sugar tests. If you have any questions, check with your doctor.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

Risperidone injection can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

This medicine may cause drowsiness, trouble with thinking, or trouble with controlling body movements, which may lead to falls, fractures, or other injuries. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

This medicine may make it more difficult for your body to cool itself down. Use care not to become overheated during exercise or hot weather since overheating may result in heat stroke. Also, use extra care not to become too cold while you are receiving risperidone injection. If you become too cold, you may feel drowsy, confused, or clumsy.

This medicine may increase your weight. Your doctor may need to check your weight on a regular basis while you are receiving this medicine.

Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS). The use of alcohol or other medicines that affect the CNS with risperidone may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics.

This medicine may increase prolactin blood levels if used for a long time. Check with your doctor if you have breast swelling or soreness, unusual breast milk production, absent, missed, or irregular menstrual periods, stopping of menstrual bleeding, loss in sexual ability, desire, drive, or performance, decreased interest in sexual intercourse, or an inability to have or keep an erection.

If you plan to have children, talk with your doctor before receiving this medicine. Some women receiving this medicine have become infertile (unable to have children).

Avoid rubbing, massaging, or placing belts or waistbands on the injection site during treatment with Perseris™.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Aggressive behavior
  2. agitation
  3. anxiety
  4. changes in vision, including blurred vision
  5. difficulty concentrating
  6. difficulty speaking or swallowing
  7. inability to move the eyes
  8. increase in amount of urine
  9. loss of balance control
  10. mask-like face
  11. memory problems
  12. muscle spasms of the face, neck, and back
  13. problems with urination
  14. restlessness or need to keep moving (severe)
  15. shuffling walk
  16. skin rash or itching
  17. stiffness or weakness of the arms or legs
  18. tic-like or twitching movements
  19. trembling and shaking of the fingers and hands
  20. trouble sleeping
  21. twisting body movements

Less common

  1. Back pain
  2. chest pain
  3. speech or vision problems
  4. sudden weakness or numbness in the face, arms, or legs

Rare

  1. Confusion
  2. dizziness
  3. drowsiness
  4. extreme thirst
  5. fast, shallow breathing
  6. fast, weak heartbeat
  7. headache
  8. increased thirst
  9. lip smacking or puckering
  10. loss of appetite
  11. muscle cramps
  12. pale, clammy skin
  13. poor coordination
  14. prolonged, painful, inappropriate erection of the penis
  15. puffing of the cheeks
  16. rapid or worm-like movements of the tongue
  17. shivering
  18. talking, feeling, and acting with excitement and activity that cannot be controlled
  19. uncontrolled chewing movements
  20. uncontrolled twisting movements of the neck, trunk, arms, or legs
  21. unusual bleeding or bruising
  22. unusual facial expressions or body positions

Incidence not known

  1. Abnormal growth filled with fluid or semisolid material
  2. accumulation of pus
  3. black, tarry stools
  4. bleeding gums
  5. bloating
  6. blood in the urine or stools
  7. bluish lips or skin
  8. break in the skin, especially associated with blue-black discoloration, swelling, or drainage of fluid
  9. change in mental status
  10. chills
  11. clumsiness
  12. cold sweats
  13. collection of blood under the skin
  14. constipation
  15. cough
  16. dark urine
  17. decrease in the frequency of urination
  18. decreased awareness or responsiveness
  19. decreased urine output
  20. deep, dark purple bruise
  21. depression
  22. diarrhea
  23. dry mouth
  24. fainting
  25. fast or irregular heartbeat
  26. fever
  27. flushed, dry skin
  28. fruit-like breath odor
  29. hives
  30. hostility
  31. inability to move the eyes
  32. increased blinking or spasms of the eyelid
  33. increased hunger
  34. indigestion
  35. irregular heartbeat, recurrent
  36. irritability
  37. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  38. loss of consciousness
  39. low body temperature
  40. mimicry of speech or movements
  41. muscle ache, twitching, or weakness
  42. nausea
  43. nervousness
  44. nightmares
  45. painful urination
  46. pains in the stomach, side, or abdomen, possibly radiating to the back
  47. peculiar postures or movements, mannerisms, or grimacing
  48. pinpoint red spots on the skin
  49. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  50. rapid weight gain
  51. red irritated eyes
  52. red skin lesions, often with a purple center
  53. seizures
  54. severe constipation
  55. severe sleepiness
  56. severe vomiting
  57. shakiness
  58. small lumps under the skin
  59. sore throat
  60. sores on the skin
  61. sores, ulcers, or white spots in the mouth or on the lips
  62. sticking out of the tongue
  63. stomach pain
  64. swelling of the face, ankles, or hands
  65. swollen, red, tender area of infection
  66. tightness in the chest
  67. trouble breathing
  68. twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  69. unexplained weight loss
  70. unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  71. vomiting
  72. weak or feeble pulse
  73. weight gain
  74. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Heartburn
  2. increased dream activity
  3. increased length of sleep
  4. stuffy or runny nose

Less common

  1. Absent, missed, or irregular menstrual periods
  2. bleeding, blistering, burning, discoloration of the skin, infection, inflammation, itching, lumps, numbness, pain, rash, redness, soreness, stinging, swelling, tenderness, tingling, or warmth at the injection site
  3. body aches or pain
  4. breast swelling or soreness
  5. dandruff
  6. darkening of skin color
  7. decreased interest in sexual intercourse
  8. dry skin
  9. ear congestion
  10. inability to have or keep an erection
  11. increase in body movements
  12. increased watering of the mouth
  13. joint pain
  14. loss in sexual ability, desire, drive, or performance
  15. loss of voice
  16. oily skin
  17. pain or tenderness around the eyes and cheekbones
  18. sneezing
  19. stopping of menstrual bleeding
  20. toothache
  21. unusual breast milk production
  22. weight loss

Incidence not known

  1. Acne
  2. change in taste
  3. enlargement of the penis or testes
  4. growth of pubic hair
  5. loss or thinning of the hair
  6. loss of taste
  7. rapid increase in height
  8. sleepwalking

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.