Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of olanzapine and fluoxetine combination to treat bipolar I depression in children younger than 10 years of age, and in children with treatment resistant depression. Safety and efficacy have not been established in these groups.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of olanzapine and fluoxetine combination in the elderly. However, elderly patients are more likely to have dementia or age-related liver, kidney, or heart problems, which may require caution or an adjustment in the dose for patients receiving olanzapine and fluoxetine combination.

Breastfeeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bepridil
  • Bromopride
  • Cisapride
  • Clorgyline
  • Dronedarone
  • Eliglustat
  • Isocarboxazid
  • Levoketoconazole
  • Levomethadyl
  • Linezolid
  • Mavacamten
  • Mesoridazine
  • Methylene Blue
  • Metoclopramide
  • Nialamide
  • Ozanimod
  • Phenelzine
  • Pimozide
  • Piperaquine
  • Potassium Citrate
  • Procarbazine
  • Rasagiline
  • Safinamide
  • Saquinavir
  • Selegiline
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Toloxatone
  • Tranylcypromine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abametapir
  • Abciximab
  • Abiraterone Acetate
  • Aceclofenac
  • Acemetacin
  • Acenocoumarol
  • Acepromazine
  • Adagrasib
  • Alfentanil
  • Alfuzosin
  • Almotriptan
  • Alprazolam
  • Amantadine
  • Amineptine
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amitriptylinoxide
  • Amobarbital
  • Amoxapine
  • Amphetamine
  • Amtolmetin Guacil
  • Anagrelide
  • Anileridine
  • Apalutamide
  • Apixaban
  • Apomorphine
  • Apomorphine Hydrochloride
  • Aprindine
  • Ardeparin
  • Argatroban
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Asenapine
  • Aspirin
  • Astemizole
  • Atazanavir
  • Atomoxetine
  • Azithromycin
  • Baclofen
  • Bedaquiline
  • Belzutifan
  • Bemiparin
  • Benperidol
  • Benzhydrocodone
  • Benzphetamine
  • Betrixaban
  • Bivalirudin
  • Brexpiprazole
  • Bromazepam
  • Bromfenac
  • Bromocriptine Mesylate
  • Brompheniramine
  • Bufexamac
  • Buprenorphine
  • Bupropion
  • Buserelin
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Cabergoline
  • Calcium Oxybate
  • Cangrelor
  • Cannabidiol
  • Cannabis
  • Capmatinib
  • Carbamazepine
  • Carbinoxamine
  • Carisoprodol
  • Carphenazine
  • Carvedilol
  • Celecoxib
  • Ceritinib
  • Certoparin
  • Cetirizine
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chloroquine
  • Chlorpheniramine
  • Chlorpromazine
  • Chlorzoxazone
  • Choline Salicylate
  • Cilostazol
  • Cimetidine
  • Cinacalcet
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clobazam
  • Clofazimine
  • Clomipramine
  • Clonazepam
  • Clonixin
  • Clopidogrel
  • Clorazepate
  • Clothiapine
  • Clozapine
  • Cobicistat
  • Cocaine
  • Codeine
  • Crizotinib
  • Cyclobenzaprine
  • Dabigatran Etexilate
  • Dabrafenib
  • Dacomitinib
  • Dalteparin
  • Danaparoid
  • Daridorexant
  • Darunavir
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Desirudin
  • Deslorelin
  • Desmopressin
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexfenfluramine
  • Dexibuprofen
  • Dexketoprofen
  • Dexmedetomidine
  • Dextroamphetamine
  • Dextromethorphan
  • Diacetylmorphine
  • Diazepam
  • Dibenzepin
  • Dichloralphenazone
  • Diclofenac
  • Difenoxin
  • Diflunisal
  • Digoxin
  • Dihydrocodeine
  • Diphenhydramine
  • Diphenoxylate
  • Dipyridamole
  • Dipyrone
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Doxylamine
  • Droperidol
  • Droxicam
  • Duloxetine
  • Ebastine
  • Edoxaban
  • Efavirenz
  • Eletriptan
  • Encainide
  • Enclomiphene
  • Encorafenib
  • Enflurane
  • Enoxacin
  • Enoxaparin
  • Entrectinib
  • Enzalutamide
  • Epoprostenol
  • Eptifibatide
  • Eribulin
  • Erythromycin
  • Escitalopram
  • Esketamine
  • Estazolam
  • Eszopiclone
  • Ethchlorvynol
  • Ethopropazine
  • Ethylmorphine
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Etrasimod
  • Famotidine
  • Fedratinib
  • Felbamate
  • Felbinac
  • Fenfluramine
  • Fenoldopam Mesylate
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Fexinidazole
  • Fingolimod
  • Flecainide
  • Flibanserin
  • Floctafenine
  • Fluconazole
  • Flufenamic Acid
  • Flunitrazepam
  • Fluoxetine
  • Fluphenazine
  • Flurazepam
  • Flurbiprofen
  • Fluspirilene
  • Fluvoxamine
  • Fondaparinux
  • Formoterol
  • Foscarnet
  • Fosphenytoin
  • Fospropofol
  • Fostemsavir
  • Frovatriptan
  • Gabapentin
  • Gabapentin Enacarbil
  • Galantamine
  • Gatifloxacin
  • Gemifloxacin
  • Gepirone
  • Gilteritinib
  • Glasdegib
  • Glucagon
  • Glycopyrrolate
  • Glycopyrronium Tosylate
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halazepam
  • Halofantrine
  • Haloperidol
  • Halothane
  • Heparin
  • Hexobarbital
  • Histrelin
  • Hydrocodone
  • Hydromorphone
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxytryptophan
  • Hydroxyzine
  • Ibuprofen
  • Ibutilide
  • Iloperidone
  • Iloprost
  • Imipramine
  • Indomethacin
  • Inotuzumab Ozogamicin
  • Iobenguane I 123
  • Iobenguane I 131
  • Isoflurane
  • Isradipine
  • Itraconazole
  • Ivabradine
  • Ivosidenib
  • Ketamine
  • Ketazolam
  • Ketobemidone
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Lacosamide
  • Lapatinib
  • Lasmiditan
  • Lefamulin
  • Lemborexant
  • Lenvatinib
  • Lepirudin
  • Leuprolide
  • Levocetirizine
  • Levodopa
  • Levofloxacin
  • Levomilnacipran
  • Levorphanol
  • Lidoflazine
  • Lisdexamfetamine
  • Lithium
  • Lofepramine
  • Lofexidine
  • Lorcaserin
  • Lornoxicam
  • Loxapine
  • Loxoprofen
  • Lumacaftor
  • Lumefantrine
  • Lumiracoxib
  • Macimorelin
  • Magnesium Oxybate
  • Meclizine
  • Meclofenamate
  • Mefenamic Acid
  • Mefloquine
  • Melitracen
  • Meloxicam
  • Melperone
  • Meperidine
  • Mephobarbital
  • Meprobamate
  • Meptazinol
  • Mesoridazine
  • Metaxalone
  • Methacholine
  • Methadone
  • Methamphetamine
  • Methdilazine
  • Methocarbamol
  • Methohexital
  • Methotrimeprazine
  • Methoxyphenamine
  • Methylene Blue
  • Methylphenidate
  • Metoclopramide
  • Metronidazole
  • Mexiletine
  • Mifepristone
  • Milnacipran
  • Mirtazapine
  • Mitotane
  • Mizolastine
  • Mobocertinib
  • Molindone
  • Moricizine
  • Morniflumate
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nabumetone
  • Nadroparin
  • Nafarelin
  • Nalbuphine
  • Naproxen
  • Naratriptan
  • Nebivolol
  • Nefazodone
  • Nelfinavir
  • Nepafenac
  • Nicergoline
  • Nicomorphine
  • Nifedipine
  • Niflumic Acid
  • Nilotinib
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nitrazepam
  • Nitrous Oxide
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Omeprazole
  • Ondansetron
  • Opipramol
  • Opium
  • Opium Alkaloids
  • Orphenadrine
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxaprozin
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Oxyphenbutazone
  • Ozanimod
  • Pacritinib
  • Paliperidone
  • Palonosetron
  • Panobinostat
  • Papaveretum
  • Papaverine
  • Parecoxib
  • Paregoric
  • Parnaparin
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Pentazocine
  • Pentobarbital
  • Perampanel
  • Perazine
  • Periciazine
  • Perphenazine
  • Phenindione
  • Phenobarbital
  • Phenprocoumon
  • Phenylbutazone
  • Phenytoin
  • Piketoprofen
  • Pimavanserin
  • Pipamperone
  • Piperacetazine
  • Pipotiazine
  • Piritramide
  • Piroxicam
  • Pitolisant
  • Pixantrone
  • Ponesimod
  • Posaconazole
  • Potassium Oxybate
  • Prajmaline
  • Pramipexole Dihydrochloride
  • Pranoprofen
  • Prasugrel
  • Prazepam
  • Pregabalin
  • Pridopidine
  • Primidone
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Proglumetacin
  • Promazine
  • Promethazine
  • Propafenone
  • Propofol
  • Propranolol
  • Propyphenazone
  • Proquazone
  • Protein C
  • Protriptyline
  • Quazepam
  • Quetiapine
  • Quinidine
  • Quinine
  • Quizartinib
  • Ramelteon
  • Ranolazine
  • Relugolix
  • Remifentanil
  • Remimazolam
  • Remoxipride
  • Revefenacin
  • Reviparin
  • Ribociclib
  • Rifampin
  • Risperidone
  • Ritonavir
  • Rivaroxaban
  • Rizatriptan
  • Rofecoxib
  • Rolapitant
  • Ropeginterferon Alfa-2b-njft
  • Ropinirole Hydrochloride
  • Rotigotine
  • Salicylic Acid
  • Salsalate
  • Scopolamine
  • Secobarbital
  • Secretin Human
  • Selexipag
  • Selpercatinib
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Sibutramine
  • Siponimod
  • Sodium Oxybate
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Sodium Salicylate
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spiramycin
  • St John's Wort
  • Sufentanil
  • Sulfamethoxazole
  • Sulfinpyrazone
  • Sulindac
  • Sulodexide
  • Sulpiride
  • Sultopride
  • Sumatriptan
  • Sunitinib
  • Suvorexant
  • Tacrolimus
  • Tamoxifen
  • Tapentadol
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Temazepam
  • Tenoxicam
  • Terbinafine
  • Tetrabenazine
  • Thiethylperazine
  • Thiopental
  • Thiopropazate
  • Tianeptine
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tilidine
  • Timolol
  • Tinzaparin
  • Tiotropium
  • Tirofiban
  • Tizanidine
  • Tolfenamic Acid
  • Tolmetin
  • Tolonium Chloride
  • Tolperisone
  • Tolterodine
  • Topiramate
  • Toremifene
  • Tramadol
  • Trazodone
  • Treprostinil
  • Triazolam
  • Triclabendazole
  • Trifluoperazine
  • Trifluperidol
  • Triflupromazine
  • Trimeprazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Tropisetron
  • Tryptophan
  • Valbenazine
  • Valdecoxib
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vernakalant
  • Vilanterol
  • Vilazodone
  • Vinblastine
  • Vinflunine
  • Voclosporin
  • Vorapaxar
  • Voriconazole
  • Vorinostat
  • Vortioxetine
  • Warfarin
  • Yohimbine
  • Zaleplon
  • Zolmitriptan
  • Zolpidem
  • Zopiclone
  • Zotepine
  • Zuclopenthixol
  • Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alprazolam
  • Amprenavir
  • Betel Nut
  • Cyproheptadine
  • Delavirdine
  • Diazepam
  • Fosamprenavir
  • Ginkgo
  • Metoprolol
  • Valproic Acid

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol
  • Tobacco

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bipolar disorder (mood disorder with mania and depression), or risk of or
  • Bleeding problems or
  • Breast cancer, prolactin-dependent or
  • Diabetes or
  • Glaucoma, angle-closure type or
  • Hyperglycemia (high blood sugar) or
  • Hyperlipidemia (increased blood cholesterol or fats) or
  • Hyperprolactinemia (increased prolactin in the blood) or
  • Hyponatremia (low sodium levels in the blood) or
  • Mania, history of or
  • Paralytic ileus (bowels stop moving), or history of or
  • Prostatic hypertrophy (enlarged prostate), or history of or
  • Seizures, history of or
  • Trouble swallowing or
  • Urinary retention (problems with passing urine), or history of—Use with caution. May make these conditions worse.
  • Blood vessel or circulation problems or
  • Dehydration or
  • Heart attack or stroke, history of or
  • Heart disease or
  • Heart failure or
  • Heart rhythm problems (eg, QT prolongation), or history of or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Hypovolemia (low blood volume)—May cause side effects to become worse.
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.