Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Mifeprex® tablets in pregnant women younger than 17 years of age.

Appropriate studies have not been performed on the relationship of age to the effects of Korlym™ tablets in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of Mifeprex® tablets in geriatric patients.

Although appropriate studies on the relationship of age to the effects of Korlym™ tablets have not been performed in the geriatric population, no geriatric-specific problems have been documented to date.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bepridil
  • Cisapride
  • Colchicine
  • Cyclosporine
  • Dihydroergotamine
  • Dronedarone
  • Ergotamine
  • Fentanyl
  • Fluconazole
  • Gepirone
  • Ketoconazole
  • Levoketoconazole
  • Lovastatin
  • Mavacamten
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Quinidine
  • Saquinavir
  • Simvastatin
  • Sirolimus
  • Sparfloxacin
  • Tacrolimus
  • Terfenadine
  • Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adagrasib
  • Alfentanil
  • Alprazolam
  • Amiodarone
  • Amisulpride
  • Anagrelide
  • Apomorphine
  • Aprepitant
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Asciminib
  • Asenapine
  • Astemizole
  • Atazanavir
  • Azithromycin
  • Benzhydrocodone
  • Boceprevir
  • Bosutinib
  • Buprenorphine
  • Buserelin
  • Capivasertib
  • Carbamazepine
  • Ceritinib
  • Chloroquine
  • Chlorpromazine
  • Cilostazol
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clomipramine
  • Clothiapine
  • Clozapine
  • Cobicistat
  • Codeine
  • Conivaptan
  • Crizotinib
  • Dabrafenib
  • Daridorexant
  • Dasabuvir
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Deutetrabenazine
  • Dexmedetomidine
  • Digoxin
  • Dihydrocodeine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Droperidol
  • Efavirenz
  • Elexacaftor
  • Encorafenib
  • Entrectinib
  • Erythromycin
  • Escitalopram
  • Etrasimod
  • Everolimus
  • Fedratinib
  • Fexinidazole
  • Finerenone
  • Fingolimod
  • Flecainide
  • Fluoxetine
  • Fluticasone
  • Formoterol
  • Fosaprepitant
  • Foscarnet
  • Fosphenytoin
  • Fostemsavir
  • Gemifloxacin
  • Glasdegib
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Hydrocodone
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Idelalisib
  • Ifosfamide
  • Iloperidone
  • Imipramine
  • Indinavir
  • Inotuzumab Ozogamicin
  • Itraconazole
  • Ivabradine
  • Ivacaftor
  • Ivosidenib
  • Lapatinib
  • Lefamulin
  • Lemborexant
  • Lenvatinib
  • Leuprolide
  • Levofloxacin
  • Levomilnacipran
  • Lofexidine
  • Lopinavir
  • Lumefantrine
  • Lurbinectedin
  • Macimorelin
  • Mefloquine
  • Meperidine
  • Methadone
  • Metronidazole
  • Mirtazapine
  • Mobocertinib
  • Moxifloxacin
  • Nafarelin
  • Naloxegol
  • Nefazodone
  • Nelfinavir
  • Nifedipine
  • Nilotinib
  • Nirogacestat
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Olaparib
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxycodone
  • Ozanimod
  • Pacritinib
  • Paliperidone
  • Palovarotene
  • Panobinostat
  • Pasireotide
  • Pazopanib
  • Pentazocine
  • Phenobarbital
  • Phenytoin
  • Pimavanserin
  • Pitolisant
  • Ponesimod
  • Pralsetinib
  • Primidone
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinine
  • Quizartinib
  • Ranolazine
  • Relugolix
  • Repotrectinib
  • Ribociclib
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
  • Roflumilast
  • Selpercatinib
  • Sertraline
  • Sevoflurane
  • Simeprevir
  • Siponimod
  • Sirolimus Protein-Bound
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • St John's Wort
  • Sufentanil
  • Sulpiride
  • Sunitinib
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Tetrabenazine
  • Tezacaftor
  • Toremifene
  • Tramadol
  • Trazodone
  • Triclabendazole
  • Trifluoperazine
  • Trimipramine
  • Triptorelin
  • Valbenazine
  • Vamorolone
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vilanterol
  • Vilazodone
  • Vinflunine
  • Voclosporin
  • Voriconazole
  • Ziprasidone
  • Zolpidem
  • Zuclopenthixol
  • Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amlodipine
  • Fluvastatin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Abnormal vaginal bleeding, history of or
  • Adrenal failure, chronic or
  • Bleeding problems or
  • Ectopic pregnancy (eg, a pregnancy that develops in fallopian tubes instead of the uterus) or
  • Endometrial hyperplasia or cancer or
  • Lower abdominal mass that is undiagnosed or
  • Porphyria (an enzyme problem)—Should not be used in patients with these conditions.
  • Adrenal problems or
  • Autoimmune disorders or
  • Diabetes or
  • Heart failure or
  • Heart or blood vessel disease (eg, coronary vascular disease) or
  • Heart rhythm problem (eg, QT prolongation) or
  • Hypertension (high blood pressure) or
  • Lung disease—Use with caution. May make these conditions worse.
  • Anemia, severe or
  • Inability of blood to clot properly or
  • Poor blood circulation—Mifeprex® causes heavy bleeding in a small portion of users, this may be intensified in patients with bleeding disorders.
  • Hypokalemia (low potassium in the blood)—Should be corrected first before using this medicine.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

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