Proper Use

Drug information provided by: Merative, Micromedex®

A nurse or other trained health professional may give you this medicine. You may also be taught how to give your medicine at home. This medicine is given as a shot under your skin (eg, stomach, thigh, buttocks, or upper arm) or into a vein.

Always check the label before use, to make sure you have the correct type of insulin. Do not change the brand, type, or concentration unless your doctor tells you to. If you use a pump or other device, make sure the insulin is made for that device.

Always double-check both the concentration (strength) of your insulin and your dose. Concentration and dose are not the same. The dose is how many units of insulin you will use. The concentration tells how many units of insulin are in each milliliter (mL), such as 100 units/mL (U-100), but this does not mean you will use 100 units at a time.

Each package of Lyumjev™ contains a patient information leaflet and patient instructions. Read this leaflet carefully and make sure you understand:

  • How to prepare the medicine.
  • How to inject the medicine.
  • How to use a disposable insulin delivery device.
  • How to use an external insulin pump.
  • How and when to change the infusion set, cartridge adapter, and insulin in the external insulin pump reservoir.
  • How to dispose of syringes, needles, and injection devices.

If you use this medicine at home, you will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.Do not use the exact same spot for each injection.

Do not inject into skin areas that are tender, bruised, scaly, hard, damaged, thick, or has pits, lumps, or scars.

When used as a mealtime insulin, it should be taken at the start of a meal or within 20 minutes after you start a meal.

This medicine should be clear and colorless before you use it. Do not use it if it is cloudy, or has particles in it.

To use the KwikPen®, Tempo Pen™, or Junior KwikPen®:

  • Wash your hands with soap and water.
  • Prime the pen by removing the air from the needle and cartridge. Select 2 units when turning the dose knob.
  • Hold the pen with the needle pointing up, then gently tap the cartridge holder to collect the air bubbles at the top.
  • Push the dose knob until it stops. You should see a "0" in the dose window. Hold the dose knob in and slowly count to 5.
  • You should see insulin at the needle tip. If you do not see insulin, repeat the priming steps but not more than 4 times. If there is still no insulin, change the needle then repeat the priming steps.
  • If your dose is more than 60 units (30 units for Junior KwikPen®), you will need to give more than 1 injection. Use a new needle for each injection and repeat the priming steps.
  • When taking your dose, turn the dose knob to select the number of units you need to inject. The pen dials 1 unit (0.5 unit for Junior KwikPen®) at a time and the dose knob clicks as you turn it. Do not dial your dose by counting the clicks as this can lead to you getting too much or too little insulin.
  • Insert the needle into your skin and push the knob all the way in. Continue to hold it, then slowly count to 5 before removing it.
  • If you see "0" in the dose window, you have received the full dose. Do not redial if you do not see a "0". Reinsert the needle into your skin and finish the injection.
  • If you need 2 injections for a full dose, be sure to take the second injection.
  • Use a new needle each time you give yourself an injection. Always remove and throw the needle after each injection. Store the pen without a needle attached. Do not use the pen if it is broken or damaged.

To use the vial:

  • Wash your hands with soap and water.
  • Use only syringes that are made for insulin injections. Use a new syringe and needle each time you give yourself an injection.
  • Do not mix this medicine with any other insulin.
  • When used in an insulin pump: Carefully read and follow the external insulin pump instructions. This insulin should not be mixed with any other insulin or diluted when used in an insulin pump. The insulin lispro-aabc in the pump should be changed at least every 9 days or any time that the insulin is over 98.6°F (37°C). If you do not understand how you are to use the insulin pump, contact your doctor or pharmacist.

Do not transfer Lyumjev™ U-200 from the prefilled pen to a syringe for use.

Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form (solution):
    • For diabetes mellitus:
      • Adults and children—The dose is based on your blood sugar and must be determined by your doctor.

Missed Dose

Call your doctor or pharmacist for instructions.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Unopened medicine: Store the vials, pens, and cartridges in the refrigerator. You may store the medicine at room temperature for 28 days. Protect from light. Do not freeze. Do not use the insulin if it has been frozen. Throw away any unused medicine after 28 days.

Opened pens and cartridges: Store at room temperature, away from direct heat and light. Do not refrigerate. Throw away any opened pen or cartridge after 28 days.

Opened vials: Store in the refrigerator or at room temperature in a cool place, away from sunlight and heat. Use within 28 days.

Throw away used syringes and needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.