Description and Brand Names

Información sobre medicamentos proporcionada por: IBM Micromedex

US Brand Name

  1. Haldol
  2. Haldol Decanoate

Descriptions


Haloperidol injection is used to treat nervous, emotional, and mental conditions (eg, schizophrenia). It is also used to control the symptoms of Tourette's disorder. This medicine should not be used to treat behavior problems in older adult patients who have dementia.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Solution
  • Oil

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of haloperidol injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of haloperidol injection in the elderly. However, elderly women are more likely to have an unwanted side effect called tardive dyskinesia, and elderly patients are more likely to have age-related heart problems, which may require an adjustment in the dose for patients receiving haloperidol injection.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bepridil
  • Bromopride
  • Cisapride
  • Dronedarone
  • Fluconazole
  • Levomethadyl
  • Mesoridazine
  • Metoclopramide
  • Nelfinavir
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Ajmaline
  • Alfentanil
  • Alfuzosin
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Anagrelide
  • Apomorphine
  • Aprindine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Astemizole
  • Azimilide
  • Azithromycin
  • Bedaquiline
  • Benzhydrocodone
  • Bretylium
  • Bromazepam
  • Bromocriptine
  • Buprenorphine
  • Bupropion
  • Buserelin
  • Butorphanol
  • Cabergoline
  • Cannabidiol
  • Ceritinib
  • Cetirizine
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clobazam
  • Clofazimine
  • Clomipramine
  • Clozapine
  • Cobicistat
  • Codeine
  • Conivaptan
  • Crizotinib
  • Dabrafenib
  • Dalfopristin
  • Darunavir
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Deutetrabenazine
  • Dibenzepin
  • Dihydrocodeine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Doxylamine
  • Droperidol
  • Efavirenz
  • Encainide
  • Encorafenib
  • Enflurane
  • Entrectinib
  • Epinephrine
  • Erythromycin
  • Escitalopram
  • Esketamine
  • Fentanyl
  • Fingolimod
  • Flecainide
  • Flibanserin
  • Fluoxetine
  • Foscarnet
  • Fosnetupitant
  • Gatifloxacin
  • Gemifloxacin
  • Glasdegib
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Histrelin
  • Hydrocodone
  • Hydromorphone
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Imipramine
  • Inotuzumab Ozogamicin
  • Itraconazole
  • Ivabradine
  • Ivosidenib
  • Ketoconazole
  • Lapatinib
  • Lefamulin
  • Lenvatinib
  • Leuprolide
  • Levodopa
  • Levofloxacin
  • Levorphanol
  • Lithium
  • Lofexidine
  • Lopinavir
  • Lorcainide
  • Loxapine
  • Lumefantrine
  • Macimorelin
  • Mefloquine
  • Meperidine
  • Methadone
  • Metronidazole
  • Mifepristone
  • Milnacipran
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nafarelin
  • Nalbuphine
  • Netupitant
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Osimertinib
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Panobinostat
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Pentazocine
  • Pergolide
  • Periciazine
  • Pimavanserin
  • Pitolisant
  • Pixantrone
  • Pramipexole
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propranolol
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Quinupristin
  • Ranolazine
  • Remifentanil
  • Ribociclib
  • Risperidone
  • Ropinirole
  • Rotigotine
  • Selegiline
  • Sematilide
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Siponimod
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spiramycin
  • Sufentanil
  • Sulfamethoxazole
  • Sulpiride
  • Sultopride
  • Sunitinib
  • Tacrolimus
  • Tapentadol
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Tetrabenazine
  • Tizanidine
  • Toremifene
  • Tramadol
  • Trazodone
  • Triclabendazole
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vinflunine
  • Voriconazole
  • Zotepine
  • Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Benztropine
  • Betel Nut
  • Buspirone
  • Carbamazepine
  • Dextromethorphan
  • Fluvoxamine
  • Methyldopa
  • Nefazodone
  • Olanzapine
  • Procyclidine
  • Rifampin
  • Rifapentine
  • Tacrine
  • Trihexyphenidyl

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Tobacco

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Breast cancer, prolactin-dependent, history of or
  • Chest pain or
  • Heart or blood vessel disease, severe or
  • Hyperprolactinemia (high prolactin in the blood) or
  • Hypotension (low blood pressure) or
  • Mania or
  • Neuroleptic malignant syndrome, history of or
  • Seizures or epilepsy, history of—Use with caution. May make these conditions worse.
  • Central nervous system depression, severe or
  • Coma or
  • Dementia in the elderly or
  • Lewy body dementia or
  • Parkinson's disease—Should not be used in patients with these conditions.
  • Heart rhythm problems (eg, familial long QT syndrome), history of or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Hypothyroidism (underactive thyroid) or
  • Lung disease (eg, bronchopneumonia) or
  • Thyrotoxicosis (overactive thyroid)—May increase risk for more serious side effects.
  • Liver disease—Use with caution. The effects may be increased because of the slower removal of the medicine from the body.

Proper Use

A nurse or other trained health professional will give you this medicine in a medical facility. It is given as a shot into one of your muscles.

Your doctor may give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Precautions

It is very important that your doctor check your progress while you receive this medicine to allow for changes in your dose and help reduce any unwanted effects.

Do not stop receiving Haldol® suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.

This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

Contact your doctor as soon as possible if you have chest pain or discomfort, a fast heartbeat, trouble with breathing, or fever and chills. These may be symptoms of a very serious problem with your heart.

This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you have any of the following symptoms while receiving this medicine: lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.

Check with your doctor right away if you have any of the following symptoms while receiving this medicine: convulsions (seizures), difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

This medicine will often make you sweat less, causing your body temperature to increase. Use extra care not to become overheated during exercise or hot weather while you are receiving this medicine, since overheating may result in heat stroke. Also, hot baths or saunas may make you feel dizzy or faint while you are receiving this medicine.

This medicine may cause some people to become dizzy, drowsy, or may cause trouble with thinking or controlling body movements, which may lead to falls, fractures or other injuries. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are receiving this medicine.

Haloperidol can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor right away if you think you are getting an infection, or if you have a fever or chills, a cough or hoarseness, lower back or side pain, or painful or difficult urination.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Haloperidol®
  1. Excessive muscle tone
  2. inability to move the eyes
  3. increase in body movements
  4. increased blinking or spasms of the eyelid
  5. muscle stiffness, tension, or tightness
  6. sleepiness or unusual drowsiness
  7. sticking out of the tongue
  8. tremor
  9. trouble with breathing, speaking, or swallowing
  10. uncontrolled twisting movements of the neck, trunk, arms, or legs
  11. unusual facial expressions
Haloperidol® Decanoate
  1. Difficulty swallowing
  2. fixed position of the eye
  3. loss of balance control
  4. mask-like face
  5. shuffling walk
  6. slowed movements
  7. slurred speech
  8. stiffness of the arms and legs
  9. tic-like or jerky movements of the head, face, mouth, and neck
  10. trembling and shaking of the fingers and hands

Less common

Haloperidol®
  1. Slow movement and reflexes
Haloperidol® Decanoate
  1. Absence of or decrease in body movement
  2. inability to sit still
  3. need to keep moving
  4. restlessness

Rare (both)

  1. Blurred vision
  2. confusion
  3. difficulty opening the mouth
  4. dizziness
  5. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  6. fainting
  7. fast, pounding, or irregular heartbeat or pulse
  8. high fever
  9. high or low blood pressure
  10. increased sweating
  11. lightheadedness
  12. lockjaw
  13. loss of bladder control
  14. muscle spasm, especially of the neck and back
  15. muscle twitching
  16. seizures
  17. severe muscle stiffness
  18. uncontrolled eye movements
  19. unusual tiredness or weakness
  20. unusually pale skin

Incidence not known (both)

  1. Anxiety
  2. black, tarry stools
  3. bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, or warmth at the injection site
  4. chest pain
  5. chills
  6. clay-colored stools
  7. cold sweats
  8. continuing nausea or vomiting
  9. cool, pale skin
  10. cough
  11. dark urine
  12. decrease in the frequency of urination
  13. deep or fast breathing with dizziness
  14. depression
  15. difficulty in passing urine (dribbling)
  16. drooling
  17. dry mouth
  18. eye pain
  19. false or unusual sense of well-being
  20. fever with or without chills
  21. flushed, dry skin
  22. fruit-like breath odor
  23. general feeling of illness, tiredness, or weakness
  24. headache
  25. hoarseness
  26. hot, dry skin
  27. increase in the frequency of seizures
  28. increased hunger
  29. increased thirst
  30. increased urination
  31. irregular heartbeat, recurrent
  32. irritability
  33. itching, skin rash
  34. lack of sweating
  35. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  36. lip smacking or puckering
  37. loss of appetite
  38. loss of consciousness
  39. lower back or side pain
  40. muscle weakness
  41. muscle pain or cramps
  42. muscle trembling or jerking
  43. nausea
  44. nervousness
  45. nightmares
  46. noisy breathing
  47. numbness of the feet, hands, and around the mouth
  48. painful or difficult urination
  49. pale skin
  50. pounding in the ears
  51. puffing of the cheeks
  52. rapid or worm-like movements of the tongue
  53. shakiness
  54. shuffling walk
  55. sore throat
  56. sores, ulcers, or white spots on the lips or in the mouth
  57. stomach pain
  58. swelling of the face, ankles, or hands
  59. swollen glands
  60. tightness in the chest
  61. total body jerking
  62. trouble with sleeping
  63. troubled breathing with exertion
  64. twisting movements of the body
  65. uncontrolled chewing movements
  66. unexplained weight loss
  67. unpleasant breath odor
  68. unusual bleeding or bruising
  69. unusual dullness, tiredness, weakness, or feeling of sluggishness
  70. vomiting
  71. vomiting of blood
  72. weakness of the arms and legs
  73. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Haloperidol®
  1. Constipation
  2. increased watering of the mouth

Rare (both)

  1. Absent, missed, or irregular menstrual periods
  2. acne, pimples
  3. breast discomfort
  4. cramps
  5. decreased interest in sexual intercourse
  6. heavy bleeding
  7. inability to have or keep an erection
  8. increased weight
  9. loss in sexual ability, desire, drive, or performance
  10. medium to heavy, irregular vaginal bleeding between regular monthly periods, which may require the use of a pad or a tampon
  11. stopping of menstrual bleeding
  12. swelling of the breasts or unusual milk production

Incidence not known (both)

  1. Belching
  2. blindness
  3. changes in vision
  4. decreased vision
  5. difficulty having a bowel movement
  6. disturbed color perception
  7. double vision
  8. drowsiness
  9. feeling of constant movement of self or surroundings
  10. fullness or swelling of the breasts
  11. halos around lights
  12. heartburn
  13. increased in sexual ability, desire, drive, or performance
  14. increased interest in sexual intercourse
  15. increased sensitivity of the skin to sunlight
  16. indigestion
  17. loss of hair
  18. night blindness
  19. overbright appearance of lights
  20. pain or tenderness of the breasts
  21. painful or prolonged erection of the penis
  22. redness or other discoloration of the skin
  23. sensation of spinning
  24. severe sunburn
  25. stomach discomfort or upset
  26. tunnel vision
  27. weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.