Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

  1. Ascriptin
  2. Aspergum
  3. Aspirtab
  4. Bayer
  5. Easprin
  6. Ecotrin
  7. Ecpirin
  8. Entercote
  9. Genacote
  10. Halfprin
  11. Ninoprin
  12. Norwich Aspirin

Descriptions


Aspirin extended-release capsules are used to lower risk of heart attack in patients with chronic coronary artery disease, such as patients with history of heart attack or angina (severe chest pain). It is also used to lower risk of recurrent stroke in patients who had an ischemic stroke or transient ischemic attack.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Capsule, Extended Release, 24 HR
  • Tablet, Chewable
  • Capsule, Liquid Filled
  • Tablet, Enteric Coated
  • Tablet

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of aspirin extended-release capsules in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aspirin extended-release capsules in the elderly.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Abrocitinib
  • Defibrotide
  • Dichlorphenamide
  • Influenza Virus Vaccine, Live
  • Ketorolac

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Acenocoumarol
  • Acetazolamide
  • Alclometasone
  • Aldosterone
  • Alipogene Tiparvovec
  • Alteplase, Recombinant
  • Amcinonide
  • Amikacin
  • Amiloride
  • Amineptine
  • Amitriptyline
  • Amitriptylinoxide
  • Amoxapine
  • Amphotericin B
  • Amtolmetin Guacil
  • Anagrelide
  • Anisindione
  • Apixaban
  • Ardeparin
  • Argatroban
  • Bacitracin
  • Beclomethasone
  • Bemetizide
  • Bemiparin
  • Benazepril
  • Bendroflumethiazide
  • Benzthiazide
  • Betamethasone
  • Betrixaban
  • Bivalirudin
  • Brinzolamide
  • Bromfenac
  • Budesonide
  • Bufexamac
  • Bumetanide
  • Caplacizumab-yhdp
  • Capreomycin
  • Captopril
  • Celecoxib
  • Certoparin
  • Chlorothiazide
  • Chlorpropamide
  • Chlorthalidone
  • Choline Salicylate
  • Ciclesonide
  • Cilostazol
  • Cisplatin
  • Citalopram
  • Clobetasol
  • Clobetasone
  • Clocortolone
  • Clomipramine
  • Clonixin
  • Clopamide
  • Clopidogrel
  • Cortisone
  • Curcumin
  • Cyclopenthiazide
  • Cyclosporine
  • Cyclothiazide
  • Dabigatran Etexilate
  • Dalteparin
  • Danaparoid
  • Deflazacort
  • Desipramine
  • Desirudin
  • Desmopressin
  • Desonide
  • Desoximetasone
  • Desvenlafaxine
  • Dexamethasone
  • Dexibuprofen
  • Dexketoprofen
  • Diazoxide
  • Dibenzepin
  • Diclofenac
  • Dicumarol
  • Diflorasone
  • Diflucortolone
  • Diflunisal
  • Difluprednate
  • Digoxin
  • Dipyrone
  • Dorzolamide
  • Dothiepin
  • Doxepin
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Emtricitabine
  • Enalapril
  • Enalaprilat
  • Enoxaparin
  • Eplerenone
  • Eptifibatide
  • Escitalopram
  • Ethacrynic Acid
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Etozolin
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Feverfew
  • Floctafenine
  • Flucloronide
  • Fludrocortisone
  • Flufenamic Acid
  • Flumethasone
  • Flunisolide
  • Fluocinolone
  • Fluocinonide
  • Fluocortin
  • Fluocortolone
  • Fluorometholone
  • Fluoxetine
  • Flurandrenolide
  • Flurbiprofen
  • Fluticasone
  • Fluvoxamine
  • Fondaparinux
  • Foscarnet
  • Fosinopril
  • Fosphenytoin
  • Furosemide
  • Gentamicin
  • Ginkgo
  • Glimepiride
  • Glipizide
  • Glyburide
  • Gossypol
  • Halcinonide
  • Halobetasol
  • Heparin
  • Hydrochlorothiazide
  • Hydrocortisone
  • Hydroflumethiazide
  • Ibrutinib
  • Ibuprofen
  • Imipramine
  • Indapamide
  • Indomethacin
  • Inotersen
  • Kanamycin
  • Ketoprofen
  • Lepirudin
  • Levomilnacipran
  • Lisinopril
  • Lithium
  • Lofepramine
  • Lornoxicam
  • Loteprednol
  • Loxoprofen
  • Lumiracoxib
  • Macimorelin
  • Meclofenamate
  • Medrysone
  • Mefenamic Acid
  • Melitracen
  • Meloxicam
  • Melphalan
  • Metformin
  • Methazolamide
  • Methotrexate
  • Methyclothiazide
  • Methylprednisolone
  • Metolazone
  • Milnacipran
  • Moexipril
  • Mometasone
  • Morniflumate
  • Nabumetone
  • Nadroparin
  • Naproxen
  • Nateglinide
  • Nefazodone
  • Neomycin
  • Nepafenac
  • Netilmicin
  • Nicorandil
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nortriptyline
  • Opipramol
  • Oxaprozin
  • Oxyphenbutazone
  • Paramethasone
  • Parecoxib
  • Parnaparin
  • Paromomycin
  • Paroxetine
  • Pemetrexed
  • Pentosan Polysulfate Sodium
  • Pentoxifylline
  • Perindopril
  • Phenindione
  • Phenprocoumon
  • Phenylbutazone
  • Phenytoin
  • Piketoprofen
  • Piracetam
  • Piretanide
  • Piroxicam
  • Plazomicin
  • Polythiazide
  • Potassium Citrate
  • Pranoprofen
  • Prasugrel
  • Prednicarbate
  • Prednisolone
  • Prednisone
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Protein C
  • Protriptyline
  • Quinapril
  • Quinethazone
  • Ramipril
  • Repaglinide
  • Reteplase, Recombinant
  • Reviparin
  • Rimexolone
  • Rivaroxaban
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Selumetinib
  • Sertraline
  • Sodium Salicylate
  • Spectinomycin
  • Spirapril
  • Spironolactone
  • Streptomycin
  • Sulindac
  • Sulodexide
  • Tacrolimus
  • Tenofovir Alafenamide
  • Tenofovir Disoproxil Fumarate
  • Tenoxicam
  • Tianeptine
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Tobramycin
  • Tolazamide
  • Tolbutamide
  • Tolfenamic Acid
  • Tolmetin
  • Torsemide
  • Trandolapril
  • Trazodone
  • Treprostinil
  • Triamcinolone
  • Triamterene
  • Trichlormethiazide
  • Trimipramine
  • Turmeric
  • Valdecoxib
  • Valproic Acid
  • Vancomycin
  • Varicella Virus Vaccine, Live
  • Venlafaxine
  • Vilazodone
  • Vortioxetine
  • Warfarin
  • Xipamide

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol
  • Atenolol
  • Betaxolol
  • Bisoprolol
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Delapril
  • Esmolol
  • Imidapril
  • Labetalol
  • Levobunolol
  • Metipranolol
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Nitroglycerin
  • Oxprenolol
  • Penbutolol
  • Pindolol
  • Probenecid
  • Propranolol
  • Sotalol
  • Streptokinase
  • Tamarind
  • Temocapril
  • Tenecteplase
  • Timolol

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to nonsteroidal anti-inflammatory drugs (NSAIDs) or
  • Asthma with nasal polyps and rhinitis, history of or
  • Stomach ulcers or bleeding—Should not be used in patients with these conditions.
  • Kidney disease, severe or
  • Liver disease, severe—Avoid use in patients with these conditions.

Proper Use

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Take the capsule with a full glass of water at the same time each day.

Swallow the extended-release capsule whole. Do not crush, break, or chew it.

Do not take Durlaza™ 2 hours before or 1 hour after drinking alcohol.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (extended-release capsules):
    • To lower risk of heart attack and stroke:
      • Adults—162.5 milligrams (mg) (one capsule) once a day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress while you are using this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

This medicine can not be used for treatment of a heart attack. Use an immediate-release aspirin in such an event.

Make sure your doctor knows if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy unless your doctor tells you to.

This medicine may increase risk for bleeding problems, including stomach ulcers or bleeding. This usually occurs if you are taking aspirin with certain medicines (eg, NSAIDs, blood thinner). Check with your doctor right away if you have black, tarry stools, severe or continuing stomach pain, unusual bleeding, bruising, or weakness, or vomiting of blood or material that looks like coffee grounds.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

  1. Abdominal or stomach pain, cramping, or burning
  2. black, tarry stools
  3. bloody or cloudy urine
  4. change in consciousness
  5. chest pain or discomfort
  6. confusion
  7. constipation
  8. convulsions, severe or continuing
  9. dark urine
  10. decreased frequency or amount of urine
  11. diarrhea
  12. difficult breathing
  13. drowsiness
  14. fainting
  15. fast breathing
  16. feeling that something terrible will happen
  17. fever
  18. general tiredness and weakness
  19. greatly decreased frequency of urination or amount of urine
  20. headache
  21. heartburn
  22. increased thirst
  23. indigestion
  24. irregular heartbeat
  25. light-colored stools
  26. loss of appetite
  27. loss of consciousness
  28. lower back or side pain
  29. muscle cramping and weakness
  30. muscle tremors
  31. nausea or vomiting
  32. nervousness
  33. numbness or tingling in the hands, feet, or lips
  34. panic
  35. rapid, deep breathing
  36. restlessness
  37. seizures
  38. skin rash
  39. stomach cramps
  40. swelling of the face, fingers, or lower legs
  41. unusual bleeding or bruising
  42. unusual tiredness or weakness
  43. upper right abdominal or stomach
  44. vomiting of blood or material that looks like coffee grounds
  45. weakness or heaviness of the legs
  46. weight gain
  47. yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  1. Acid or sour stomach
  2. anxiety
  3. belching
  4. dizziness
  5. dry mouth
  6. hyperventilation
  7. irritability
  8. shaking
  9. stomach discomfort, upset, or pain
  10. trouble sleeping
  11. unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.