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Clear gel from the aloe leaves has been applied to the skin to treat wounds, skin infections, burns, and for many other skin conditions. Dried latex from the aloe leaf has been taken by mouth traditionally as a laxative.

There is good scientific evidence for use of aloe latex as a laxative. However, it is unclear if it is better than other therapies for constipation. A report of liver toxicity from ingesting aloe raises a question of safety.

Aloe may benefit genital herpes, inflammatory skin conditions, and dandruff. For numerous other conditions, aloe has an unclear or lack of benefit.