John Mark B. Gubatan, M.D.

  1. Gastroenterologist
  1. Kotagiri P, Rae WM, Bergamaschi L, Pombal D, Lee JY, Noor NM, Sojwal RS, Rubin SJS, Unger LW, Tolmeijer SH, Manferrari G, Bashford-Rogers RJM, Bingham DB, Stift A, Rogalla S, Gubatan J, Lee JC, Smith KGC, McKinney EF, Boyd SD, Lyons PA. Disease-specific B cell clones are shared between patients with Crohn's disease. Nat Commun. 2025 Apr 17; 16 (1):3689
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  2. Chilukuri A, Kim M, Mitra T, Gubatan JM, Urrete J, Saxon LD, Ablack A, Mikulski Z, Dobaczewska K, Shen Z, Keir M, Yi T, Kaur P, Oliveira P, Murillo-Saich J, Chang EY, Steiner CA, Jedlicka P, Guma M, Rivera-Nieves J. A Similar Mutation in the AAUU-Rich Elements of the Mouse TNF Gene Results in a Distinct Ileocolitic Phenotype: A New Strain of TNF-Overexpressing Mice. Inflamm Bowel Dis. 2025 Apr 10; 31 (4):1067-1081
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  3. Nielsen OH, Hammerhoj A, Ainsworth MA, Gubatan J, D'Haens G. Immunogenicity of Therapeutic Antibodies Used for Inflammatory Bowel Disease: Treatment and Clinical Considerations. Drugs. 2025 Jan; 85 (1):67-85 Epub 2024 Nov 13
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  4. Fortuna GG, Banerjee R, Savid-Frontera C, Song J, Morán-Segura CM, Nguyen JV, Lekakis L, Fernandez-Pol S, Samraj AN, Naresh KN, Vazquez-Martinez M, Baz RC, Spiegel JY, Mikkilineni L, Gubatan JM, Sidana S, de Menezes Silva Corraes A, Kalariya NM, Patel KK, Shim KG, Fonseca R, Ferreri C, Voorhees PM, Richard S, Valdes CR, Sireesha Asoori, Wolf JL, Cowan AJ, Sborov DW, Locke FL, Lin Y, Wang Y, Hansen DK. Immune effector cell-associated enterocolitis following chimeric antigen receptor T-cell therapy in multiple myeloma. Blood Cancer J. 2024 Oct 16; 14(1):180.
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  5. Kellermann L, Hansen SL, Maciag G, Granau AM, Johansen JV, Teves JM, Bressan RB, Pedersen MT, Soendergaard C, Baattrup AM, Hammerhoj A, Riis LB, Gubatan J, Jensen KB, Nielsen OH. Influence of Vitamin D Receptor Signalling and Vitamin D on Colonic Epithelial Cell Fate Decisions in Ulcerative Colitis. J Crohns Colitis. 2024 Oct 15; 18 (10):1672-1689
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  6. Levitte S, Khan I, Iyahen V, Ziai J, Gubatan J, Sheng R, Glickstein SB, Sun T, Park KT, McBride J, Keir M. Differential expression of small bowel TGFbeta1 and TGFbeta3 characterizes intestinal strictures in patients with fibrostenotic Crohn's disease. Histochem Cell Biol. 2024 Sep; 162 (3):225-230 Epub 2024 May 05
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  7. Attauabi M, Steenholdt C, Poulsen A, Gubatan J, Burisch J, Nielsen OH, Seidelin JB. Network meta-analysis: Comparative onset of early effect of biologics and small molecules in moderately to severely active luminal Crohn's disease. Aliment Pharmacol Ther. 2024 Jul; 60 (2):124-143 Epub 2024 June 11
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  8. Huynh S, Achalu S, Berry R, Lin J, Wang CX, Gubatan J, Cheng AG. Some Drugs Have Two Faces: Paradoxical Colitis in a Patient with Psoriatic Arthritis Previously Treated with Etanercept and IL-17 Inhibitors. Dig Dis Sci. 2024 May; 69 (5):1602-1607 Epub 2024 Mar 19
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  9. Nielsen OH, Gubatan JM, Kolho KL, Streett SE, Maxwell C. Updates on the management of inflammatory bowel disease from periconception to pregnancy and lactation. Lancet. 2024 Mar 30; 403 (10433):1291-1303 Epub 2024 Mar 05
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  10. Kulkarni C, Liu D, Fardeen T, Dickson ER, Jang H, Sinha SR, Gubatan J. Artificial intelligence and machine learning technologies in ulcerative colitis. Therap Adv Gastroenterol. 2024; 17:17562848241272001 Epub 2024 Sept 05
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  11. Temby M, Boye TL, Hoang J, Nielsen OH, Gubatan J. Kinase Signaling in Colitis-Associated Colon Cancer and Inflammatory Bowel Disease. Biomolecules. 2023 Nov 6; 13 (11) Epub 2023 Nov 06
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  12. Gubatan J, Barber GE, Nielsen OH, Juhl CB, Maxwell C, Eisenberg ML, Streett SE. Paternal Medications in Inflammatory Bowel Disease and Male Fertility and Reproductive Outcomes: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2023 Aug; 21 (9):2222-2238 Epub 2022 July 20
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  13. Rehde A, Hendel SK, Juhl CB, Gubatan J, Nielsen OH. Effectiveness of Non-Budesonide Therapies in Management of Microscopic Colitis: A Systematic Review and Meta-analysis. Drugs. 2023 Jul; 83 (11):1027-1038 Epub 2023 June 26
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  14. Gubatan J, Frost S, Levitte S, Keyashian K. Rates and Predictors of Long-term Clinical Outcomes in Patients With Perianal Crohn's Disease on Biologic Therapy. J Clin Gastroenterol. 2023 Jul 1; 57 (6):617-623 Epub 2023 July 01
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  15. Nielsen OH, Boye TL, Gubatan J, Chakravarti D, Jaquith JB, LaCasse EC. Selective JAK1 inhibitors for the treatment of inflammatory bowel disease. Pharmacol Ther. 2023 May; 245:108402 Epub 2023 Mar 31
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  16. Karthikeyan S, Shen J, Keyashian K, Gubatan J. Small bowel adenocarcinoma in neoterminal ileum in setting of stricturing Crohn's disease: A case report and review of literature. World J Clin Cases. 2023 Mar 26; 11 (9):2021-2028
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  17. Levitte S, Yarani R, Ganguly A, Martin L, Gubatan J, Nadel HR, Franc B, Gugig R, Syed A, Goyal A, Park KT, Thakor AS. Case Series of Precision Delivery of Methylprednisolone in Pediatric Inflammatory Bowel Disease: Feasibility, Clinical Outcomes, and Identification of a Vasculitic Transcriptional Program. J Clin Med. 2023 Mar 20; 12 (6)
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  18. Attauabi M, Dahl EK, Burisch J, Gubatan J, Nielsen OH, Seidelin JB. Comparative onset of effect of biologics and small molecules in moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis. EClinicalMedicine. 2023 Mar; 57:101866 Epub 2023 Feb 16
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  19. Gubatan J, Kulkarni CV, Talamantes SM, Temby M, Fardeen T, Sinha SR. Dietary Exposures and Interventions in Inflammatory Bowel Disease: Current Evidence and Emerging Concepts. Nutrients. 2023 Jan 22; 15 (3)
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  20. Hu KA, Gubatan J. Gut microbiome–based therapeutics in inflammatory bowel disease. Clin Transl Disc. 2023; 3(2):e182.
  21. Hu KA, Shen J, Rieger K, Wei MT, Gubatan J. Subcutaneous Sweet Syndrome Successfully Treated With Ustekinumab in a Patient With Ulcerative Colitis. ACG Case Rep J. 2022 Nov; 9 (11):e00881 Epub 2022 Nov 22
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  22. Weingarden AR, Gubatan J, Singh S, Balabanis TC, Patel A, Sharma A, Habtezion A. Immune checkpoint inhibitor-mediated colitis is associated with cancer overall survival. World J Gastroenterol. 2022 Oct 21; 28 (39):5750-5763
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  23. Lee P, Wei MT, Gubatan J, Forgo E, Berry GJ, Verma R, Friedland S. De Novo Diagnosis of Lymphocytic Colitis After SARS-CoV-2 Vaccination. ACG Case Rep J. 2022 Sep; 9 (9):e00849 Epub 2022 Sept 07
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  24. Rubin SJS, Sojwal RS, Gubatan J, Rogalla S. The Tumor Immune Microenvironment in Pancreatic Ductal Adenocarcinoma: Neither Hot nor Cold. Cancers (Basel). 2022 Aug 31; 14 (17)
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  25. Gubatan J, Boye TL, Temby M, Sojwal RS, Holman DR, Sinha SR, Rogalla SR, Nielsen OH. Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer. Microorganisms. 2022 Jul 7; 10 (7) Epub 2022 July 07
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  26. Nielsen OH, Boye TL, Chakravarti D, Gubatan J. Selective tyrosine kinase 2 inhibitors in inflammatory bowel disease. Trends Pharmacol Sci. 2022 May; 43 (5):424-436 Epub 2022 Mar 08
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  27. Gubatan J, Zikos T, Spear Bishop E, Wu J, Gottfried A, Becker L, Habtezion A, Neshatian L. Gastrointestinal symptoms and healthcare utilization have increased among patients with functional gastrointestinal and motility disorders during the COVID-19 pandemic. Neurogastroenterol Motil. 2022 Apr; 34 (4):e14243 Epub 2021 Aug 11
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  28. Rubin SJS, Balabanis T, Gubatan J, Habtezion A. Disease exacerbation is common in inflammatory bowel disease patients treated with immune checkpoint inhibitors for malignancy. World J Clin Cases. 2022 Feb 26; 10 (6):1787-1794
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  29. Nielsen OH, Gubatan JM, Juhl CB, Streett SE, Maxwell C. Biologics for Inflammatory Bowel Disease and Their Safety in Pregnancy: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2022 Jan; 20 (1):74-87.e3 Epub 2020 Sept 12
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  30. Gubatan J, Rubin SJS, Bai L, Haileselassie Y, Levitte S, Balabanis T, Patel A, Sharma A, Sinha SR, Habtezion A. Vitamin D Is Associated with alpha4beta7+ Immunophenotypes and Predicts Vedolizumab Therapy Failure in Patients with Inflammatory Bowel Disease. J Crohns Colitis. 2021 Dec 18; 15 (12):1980-1990
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  31. Dai B, Hackney JA, Ichikawa R, Nguyen A, Elstrott J, Orozco LD, Sun KH, Modrusan Z, Gogineni A, Scherl A, Gubatan J, Habtezion A, Deswal M, Somsouk M, Faubion WA, Chai A, Sharafali Z, Hassanali A, Oh YS, Tole S, McBride J, Keir ME, Yi T. Dual targeting of lymphocyte homing and retention through a4ß7 and aEß7 inhibition in inflammatory bowel disease. Cell Rep Med. 2021 Aug 17; 2(8):100381.
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  32. Weingarden AR, Rubin SJS, Gubatan J. Immune checkpoint inhibitor-mediated colitis in gastrointestinal malignancies and inflammatory bowel disease. World J Gastrointest Oncol. 2021 Aug 15; 13 (8):772-798
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  33. Gottfried-Blackmore A, Namkoong H, Adler E, Martin B, Gubatan J, Fernandez-Becker N, Clarke JO, Idoyaga J, Nguyen L, Habtezion A. Gastric Mucosal Immune Profiling and Dysregulation in Idiopathic Gastroparesis. Clin Transl Gastroenterol. 2021 May 12; 12 (5):e00349
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  34. Gubatan J, Levitte S, Patel A, Balabanis T, Wei MT, Sinha SR. Artificial intelligence applications in inflammatory bowel disease: Emerging technologies and future directions. World J Gastroenterol. 2021 May 7; 27 (17):1920-1935
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  35. Gubatan J, Nielsen OH, Levitte S, Juhl CB, Maxwell C, Streett SE, Habtezion A. Biologics During Pregnancy in Women With Inflammatory Bowel Disease and Risk of Infantile Infections: A Systematic Review and Meta-Analysis. Am J Gastroenterol. 2021 Feb 1; 116 (2):243-253
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  36. Gubatan J, Keyashian K, Rubin SJS, Wang J, Buckman CA, Sinha S. Anti-Integrins for the Treatment of Inflammatory Bowel Disease: Current Evidence and Perspectives. Clin Exp Gastroenterol. 2021; 14:333-342 Epub 2021 Aug 24
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  37. Kellermann L, Jensen KB, Bergenheim F, Gubatan J, Chou ND, Moss A, Nielsen OH. Mucosal vitamin D signaling in inflammatory bowel disease. Autoimmun Rev. 2020 Nov; 19 (11):102672 Epub 2020 Sept 15
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  38. Gubatan J, Levitte S, Balabanis T, Patel A, Sharma A, Habtezion A. SARS-CoV-2 Testing, Prevalence, and Predictors of COVID-19 in Patients with Inflammatory Bowel Disease in Northern California. Gastroenterology. 2020 Sep; 159 (3):1141-1144.e2 Epub 2020 May 07
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  39. Gubatan J, Mehigan GA, Villegas F, Mitsuhashi S, Longhi MS, Malvar G, Csizmadia E, Robson S, Moss AC. Cathelicidin Mediates a Protective Role of Vitamin D in Ulcerative Colitis and Human Colonic Epithelial Cells. Inflamm Bowel Dis. 2020 May 12; 26 (6):885-897
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  40. Gubatan J, Triadafilopoulos G, Fernandez-Becker NQ. Double Threat: Interplay of Celiac Disease with Inflammatory Bowel Disease. Dig Dis Sci. 2020 Apr; 65 (4):952-956
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  41. Gubatan J, Kwo P, Hwang JH. Novel use of endoscopic morcellator to clear large obscuring clot in patient with upper-GI bleed. VideoGIE. 2020 Feb; 5 (2):58-60 Epub 2019 Nov 27
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  42. Gubatan J, Shah N. Gastric Leiomyosarcoma Unmasked by Bleeding From a Percutaneous Endoscopic Gastrostomy Tube. ACG Case Rep J. 2020 Jan; 7 (1):e00301 Epub 2020 Jan 07
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  43. Gubatan J, Chou ND, Nielsen OH, Moss AC. Systematic review with meta-analysis: association of vitamin D status with clinical outcomes in adult patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2019 Dec; 50 (11-12):1146-1158 Epub 2019 Oct 24
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  44. Nielsen OH, Hansen TI, Gubatan JM, Jensen KB, Rejnmark L. Managing vitamin D deficiency in inflammatory bowel disease. Frontline Gastroenterol. 2019 Oct; 10 (4):394-400 Epub 2019 Jan 07
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  45. Gubatan J, Moss AC. Vitamin D in inflammatory bowel disease: more than just a supplement. Curr Opin Gastroenterol. 2018 Jul; 34 (4):217-225
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  46. Gubatan J, Mitsuhashi S, Longhi MS, Zenlea T, Rosenberg L, Robson S, Moss AC. Higher serum vitamin D levels are associated with protective serum cytokine profiles in patients with ulcerative colitis. Cytokine. 2018 Mar; 103:38-45 Epub 2018 Jan 08
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  47. Gubatan J, Mitsuhashi S, Zenlea T, Rosenberg L, Robson S, Moss AC. Low Serum Vitamin D During Remission Increases Risk of Clinical Relapse in Patients With Ulcerative Colitis. Clin Gastroenterol Hepatol. 2017 Feb; 15 (2):240-246.e1 Epub 2016 June 04
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  48. Gubatan J, Staller K, Barshop K, Kuo B. Cannabis Abuse Is Increasing and Associated with Increased Emergency Department Utilization in Gastroenterology Patients. Dig Dis Sci. 2016 Jul; 61 (7):1844-52 Epub 2016 Mar 02
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  49. Gubatan J, Raines N, Khosravi H, Challies TL, Berzin TM. Hemorrhage from Extra-Antral Gastric Antral Vascular Ectasia in a Patient with Duodenal Heterotopic Gastric Mucosa. Case Rep Gastrointest Med. 2016; 2016:4325302 Epub 2016 Oct 18
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  50. Gubatan J, Wang X, Louissaint A, Mahindra A, Vanderpool J. Hypercalcemia associated with isolated bone marrow sarcoidosis in a patient with underlying monoclonal gammopathy of undetermined significance: case report and review of literature. Biomark Res. 2016; 4:18 Epub 2016 Sept 15
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  51. Tai W, Roberts L, Seryshev A, Gubatan JM, Bland CS, Zabriskie R, Kulkarni S, Soong L, Mbawuike I, Gilbert B, Kheradmand F, Corry DB. Multistrain influenza protection induced by a nanoparticulate mucosal immunotherapeutic. Mucosal Immunol. 2011 Mar; 4 (2):197-207 Epub 2010 Aug 25
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