Interactions with Drugs
Zinc may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants (blood thinners) such as warfarin (Coumadin®) or heparin, antiplatelet drugs such as clopidogrel (Plavix®), and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).
Zinc may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. People taking insulin or drugs for diabetes by mouth should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.
Zinc may also interact with acetazolamide, agents that affect the immune system, agents that are used for the blood, agents that are used for the liver, agents that are used for mental disorders, agents that are used for osteoporosis, agents that promote urination, agents that treat retrovirus infections (HIV), agents that treat ringing in the ears, angiotensin-converting enzyme inhibitors or receptor blockers, anti-acne agents, anti-arthritis agents, antibiotics, anticancer agents, antidiarrheals, antifungal agents, anti-inflammatory agents, anti-malaria agents, anti-parasite agents, anti-seizure agents, antiulcer agents, antivirals, aphrodisiacs, blood pressure-lowering agents, caffeine, calcium salts, carbenoxolone analog (BX24), central nervous system stimulants, cholera vaccine, cholesterol-lowering agents, cognitive agents, cold and flu agents, corticosteroids, deferoxamine (Desferal®), dental agents, dexrazoxane, disulfiram, ethambutol, ethanol (alcohol), exercise performance enhancement agents, eye agents, fertility agents, fluoroquinolones, H2 blockers, hormonal agents, kidney agents, methylphenidate, nervous system agents, niacin, pain relievers, pancreatic enzyme replacements, penicillamine (Cuprimine®), phenytoin, propofol, proton pump inhibitors, sickle cell agents, skin agents, stomach agents, thyroid hormones, tricyclic antidepressants, trientine, vaccines, wound-healing agents, and zidovudine.
Interactions with Herbs and Dietary Supplements
Zinc may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
Zinc may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.
Zinc may also interact with anti-arthritis herbs and supplements, antibacterials, anticancer herbs and supplements, antidepressants, antidiarrheals, antifungal herbs and supplements, anti-inflammatory herbs and supplements, anti-malaria agents, antioxidants, anti-parasite herbs and supplements, anti-seizure herbs and supplements, antiulcer herbs and supplements, antivirals, aphrodisiacs, ascorbic acid, athletic performance enhancers, blood pressure-lowering herbs and supplements, bromelain, caffeine, calcium salts, carotene, cat's claw, chelation therapy, cholesterol-lowering herbs and supplements, chromium, citric acid, cognitive herbs and supplements, cold and flu herbs and supplements, copper, dental herbs and supplements, ethanol (alcohol), fatty acids, fertility herbs and supplements, folic acid, Hemidesmus indicus, herbs and supplements believed to have estrogenic properties, herbs and supplements that affect the immune system, herbs and supplements that affect the thyroid, herbs and supplements that promote urination, herbs and supplements used for acne, herbs and supplements used for the blood, herbs and supplements used for the eyes, herbs and supplements used for the liver, herbs and supplements used for the lungs, herbs and supplements used for mental disorders, herbs and supplements used for osteoporosis, herbs and supplements used for retrovirus infections, herbs and supplements used for ringing in the ears, herbs and supplements used for the skin, hormonal herbs and supplements, IP-6 (phytic acid), iron salts, magnesium, manganese, mushroom extracts, nervous system herbs and supplements, niacin, nicotinamide, pain relievers, pancreatic enzyme replacements, phosphorous, resveratrol, riboflavin, selenium, sickle cell herbs and supplements, stimulants, stomach herbs and supplements, sugar alcohols, tartaric acid, vitamin A, vitamin D, and wound-healing herbs and supplements.
This evidence-based monograph was prepared by The Natural Standard Research Collaboration