Proper Use

Drug information provided by: IBM Micromedex

Use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Do not change your dose or stop using this medicine without checking first with your doctor.

This medicine comes with patient instructions. Read and follow these instructions carefully and make sure you understand:

  • How to prepare the nasal spray.
  • How to use the spray.
  • How long the spray can be stored.

This medicine is only used in the nose. Do not get it in your eyes or on your skin. If it does get on these areas, rinse them with water right away and call your doctor.

To use nafarelin spray:

  • Before you use each new bottle of nafarelin, the spray pump needs to be primed first. To do this, point the bottle away from you and pump the bottle firmly about 7 times until a fine mist spray appears. This only needs to be done once for each new bottle of nafarelin. Be careful not to breathe in this spray. You could inhale extra doses of nafarelin, since the medicine is dissolved in the spray.
  • Before you use nafarelin spray, blow your or your child's nose gently to clear the nostrils. You can also use a bulb syringe to clean your child's nose.
  • For central precocious puberty:
    • Tilt your child's head back slightly. Put the tip of the bottle into your child's nostril.
    • Close the other nostril with your finger. At the same time, let your child sniff in the spray as you pump the bottle once.
    • Allow 30 seconds between sprays in the same nostril.
    • Keep your child's head tilted back for a few seconds after spraying this medicine to let the spray get onto the back of the nose.
  • For endometriosis:
    • Lean your head forward. Put the spray tip into one nostril. Aim the tip toward the back and outside of your nostril. You do not need to put the tip too far into your nose.
    • Close your other nostril with your finger. At the same time, sniff in the spray as you pump the bottle once.
    • Do not spray this medicine in your other nostril unless your doctor tells you to.
    • Tilt your head backwards for a few seconds after spraying this medicine to let the spray get onto the back of your nose.
  • Repeat these steps for each dose of the medicine.
  • Each time you use the spray bottle, wipe off the tip with a clean tissue or cloth. Keep the white safety clip and plastic cap on the bottle when you are not using it.
  • Be sure to clean the tip of the spray bottle before and after every use. To do this, hold the bottle sideways. Rinse the tip with warm water, while wiping the tip with your finger or a soft cloth for about 15 seconds. Dry the tip with a soft cloth or tissue. Replace the cap right after use. Be careful not to get water into the bottle, since this could dilute the medicine.
  • Do not try to make the tiny hole in the spray tip larger. Doing so, may deliver a wrong dose of the medicine.

If you are also using a nasal decongestant, do not use it at the same time you are using this medicine. Wait at least 2 hours after using nafarelin spray before using the nasal decongestant.

Avoid sneezing when spraying and immediately after using the medicine. If you sneeze, the medicine may not be absorbed as well.

Many boys and girls who have central precocious puberty will not feel sick or will not understand the importance of taking this medicine regularly. Nafarelin must be given on a regular schedule.

Women with endometriosis should start using this medicine between the 2nd and 4th day of their menstrual period, unless instructed otherwise by your doctor. This medicine is used for six months.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For nasal dosage form (spray):
    • For treatment of central precocious puberty:
      • Children—Two sprays in each nostril 2 times a day, in the morning and in the evening. This provides a total dose of 8 sprays a day. Some patients may need a larger dose by using 3 sprays in alternating nostrils 3 times a day to provide a total of 9 sprays per day.
    • For treatment of endometriosis:
      • Adults—One spray into one nostril in the morning and one spray into the other nostril in the evening, taken for 6 months. Start your treatment between Days 2 and 4 of your menstrual period.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the bottle upright. Do not freeze. After you prime the bottle, there will only be 60 doses or sprays. Keep track of the number of sprays you use. Throw the bottle away after you use 60 sprays (for 30 days) even if some liquid remains.