Drug information provided by: Micromedex
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of dactinomycin injection in children older than 12 months of age. However, safety and efficacy have not been established in infants younger than 12 months of age.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dactinomycin injection in the elderly. However, elderly patients are more likely to have bone marrow problems, which may require caution and an adjustment in the dose for patients receiving dactinomycin injection.
Information about this dactinomycin-intravenous-route
||Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Bone marrow problems or
Kidney disease or
Liver disease or
Veno-occlusive liver disease (blocked veins in the liver)—Use with caution. May make these conditions worse.
Herpes zoster (shingles)—Should not be used in patients with these conditions.
Infection—May decrease your body's ability to fight infection.
Radiation treatment—If you are using this medicine for Wilms' tumor and you have received radiation treatment in the past two months, tell your doctor right away.