Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

  1. Cancidas


Caspofungin injection is used to treat serious fungal infections, including candidemia (fungal infection in the blood), esophageal candidiasis (fungal infection of the esophagus), other candida infections, and aspergillosis (fungal infection in the lungs). It is also used to treat fungal infections assumed to be present in patients with febrile neutropenia. Caspofungin injection is given when other medicines (eg, amphotericin B, itraconazole) did not work well.

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

  • Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of caspofungin injection in children 3 months of age and older. Safety and efficacy have not been established in children younger than 3 months of age.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of caspofungin injection in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cyclosporine
  • Levoketoconazole
  • Methotrexate
  • Tacrolimus

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Carbamazepine
  • Dexamethasone
  • Efavirenz
  • Fosphenytoin
  • Nevirapine
  • Phenytoin
  • Rifampin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Liver disease, moderate to severe (eg, hepatitis, liver failure)—Use with caution. Effects may be increased because of slower removal of the medicine from the body.

Proper Use

A nurse or other trained health professional will give you this medicine. It is given through a needle placed into one of your veins. The medicine must be injected slowly, so the needle will have to remain in place for about 1 hour for 7 to 14 days.


It is very important that your doctor check the progress of you or your child while you are taking this medicine to make sure the medicine is working properly. Blood tests may be needed to check for unwanted effects.

Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, dark urine, pale stools, nausea, vomiting, loss of appetite, or yellow skin or eyes. These could be symptoms of a serious liver problem.

This medicine may cause a serious type of allergic reaction, called anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you or your child have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or a skin rash, sores or ulcers on the skin, or fever or chills with this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Bloating or swelling of the face, arms, hands, lower legs, or feet
  2. blue lips, fingernails, or skin
  3. blurred vision
  4. changes in skin color
  5. chest pain
  6. confusion
  7. cough
  8. cracked lips
  9. decreased urine
  10. diarrhea
  11. difficult or troubled breathing
  12. difficulty with swallowing
  13. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  14. dry mouth
  15. fever
  16. headache
  17. increased thirst
  18. irregular heartbeat
  19. irregular, fast, slow, or shallow breathing
  20. loss of appetite
  21. mood changes
  22. muscle pain or cramps
  23. nausea
  24. nervousness
  25. numbness or tingling in your hands, feet, or lips
  26. pain or redness at the injection site
  27. pain, tenderness, or swelling of the foot or leg
  28. pale skin
  29. pounding in the ears
  30. rapid weight gain
  31. seizures
  32. slow or fast heartbeat
  33. sneezing
  34. sore throat
  35. sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  36. sweating
  37. tightness in the chest
  38. troubled breathing with exertion
  39. unusual bleeding or bruising
  40. unusual tiredness or weakness
  41. unusual weight gain or loss
  42. vomiting

Less common

  1. Bloody urine
  2. decreased frequency or amount of urine
  3. increased blood pressure
  4. lower back or side pain
  5. weight gain
  6. yellow eyes or skin

Incidence not known

  1. Black, tarry stools
  2. bladder pain
  3. bleeding gums
  4. blood in the urine or stools
  5. bloody nose
  6. chest pain or discomfort
  7. clay-colored stools
  8. cloudy urine
  9. constipation
  10. dark urine
  11. decreased appetite
  12. depression
  13. drowsiness
  14. fever with or without chills
  15. flushed, dry skin
  16. frequent urge to urinate
  17. fruit-like breath odor
  18. general feeling of tiredness or weakness
  19. incoherent speech
  20. increased hunger
  21. increased urination
  22. indigestion
  23. itching
  24. light-colored stools
  25. metallic taste
  26. muscle spasms (tetany) or twitching seizures
  27. muscle weakness
  28. no blood pressure or pulse
  29. noisy, rattling breathing
  30. pain or discomfort in the arms, jaw, back, or neck
  31. pains in the stomach, side, or abdomen, possibly radiating to the back
  32. pinpoint red spots on the skin
  33. rapid weight gain
  34. rash
  35. right upper abdominal or stomach pain and fullness
  36. shakiness in the legs, arms, hands, or feet
  37. stomach pain, continuous
  38. stomach pain or tenderness
  39. stopping of heart
  40. trembling or shaking of the hands or feet
  41. troubled breathing at rest
  42. ulcers, sores, or white spots in the mouth
  43. unconsciousness
  44. unexplained weight loss
  45. unpleasant breath odor
  46. vomiting of blood
  47. weakness
  48. weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Flushing, redness of the skin
  2. unusually warm skin

Incidence not known

  1. Back pain
  2. belching
  3. blistering, peeling, or loosening of the skin
  4. bloated or feeling of fullness
  5. bumps on the skin
  6. difficulty in moving
  7. dry, red, hot, or irritated skin
  8. fear
  9. flaking and falling off of the skin
  10. heartburn
  11. hives or welts
  12. indigestion
  13. joint or muscle pain
  14. lack or loss of strength
  15. muscle pain or stiffness
  16. pressure in the stomach
  17. red skin lesions, often with a purple center
  18. red, irritated eyes
  19. redness of the skin
  20. sleepiness or unusual drowsiness
  21. small red or purple spots on the skin
  22. stomach discomfort, upset, or pain
  23. swelling of the abdominal or stomach area
  24. trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.