Sweet's syndrome may go away without treatment. But medications can speed the process dramatically.

The most common medications used for Sweet's syndrome are corticosteroids, which come in a variety of forms, including:

  • Pills. Oral corticosteroids, such as prednisone, work very well but will affect your entire body. Unless you only have a few lesions, you'll likely need to take oral corticosteroids. Long-term use can cause side effects, such as weight gain, insomnia and weakened bones.
  • Creams or ointments. These preparations usually affect just the portion of skin where they're applied, but can cause thinning skin.
  • Injections. Another option is to inject a small amount of corticosteroid right into each lesion. This may be less feasible for people who have a great number of lesions.

Sometimes other medications are prescribed for Sweet's syndrome, usually for people who don't tolerate long-term corticosteroid use well. Some of the more commonly prescribed medication alternatives to corticosteroids are:

  • Dapsone
  • Potassium iodide
  • Colchicine (Colcrys, Mitigare)
Dec. 10, 2015
  1. Goldsmith LA, et al., eds. Acute febrile neutrophilic dermatosis. In: Fitzpatrick's Dermatology in General Medicine. 8th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. Accessed Sept. 24, 2015.
  2. Herbert Cohen D, et al. Sweet's syndrome. The Journal of Emergency Medicine. 2015;49:e95.
  3. Rochet NM, et al. Sweet syndrome: Clinical presentation, associations, and response to treatment in 77 patients. Journal of the American Academy of Dermatology. 2013;69:557.
  4. Goldman L, et al., eds. Macular, popular, vesiculobullous and pustular diseases. In: Goldman-Cecil Medicine. 25th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. Accessed Sept. 24, 2015.
  5. Merola, JF. Sweet syndrome (acute febrile neutrophilic dermatosis): Management and prognosis. Accessed Sept. 24, 2015.
  6. Merola, JF. Sweet syndrome (acute febrile neutrophilic dermatosis): Pathogenesis, clinical manifestations, and diagnosis. Accessed Sept. 24, 2015.
  7. Bolognia JL, et al. Neutrophilic dermatoses. In: Dermatology Essentials. Philadelphia, Pa.: Saunders Elsevier; 2014. Accessed Sept. 29, 2015.
  8. Saag KG, et al. Major side effects of systemic glucocorticoids. Accessed Sept. 24, 2015.