June 10, 2015
Below are current clinical trials.24 studies in Obesity
(open studies only).
Filter this list of studies by location, status and more.
Insufficient sleep may be one of the most common, and most preventable, obesity risk factors. The investigators wish to determine whether 14 nights of modest sleep restriction results in increased energy balance, thus potentially increasing the risk of obesity. The investigators hypothesize that sleep restriction will result in increased energy balance.
The purpose of this study is to evaluate the safety and effectiveness of the Spatz3 in subjects with a BMI ≥ 30 and < 40 who have failed to achieve and maintain weight-loss with a weight control program.
Adults who gain most of their excess weight in abdominal area or have Type 2 (adult onset) Diabetes typically do not process sugar (glucose) normally in their muscle in response to insulin, especially compared to lean adults or those who have gained most of their excess body fat in their hip and thigh areas. We know that some of this is due to differences in how fat cells release fat molecules into the bloodstream, which in turn affects muscle metabolism. We don’t know whether fat molecules in the bloodstream are handled differently by those with abdominal fat gain, type 2 diabetes or hip and thigh fat gain compared with lean adults. By measuring how muscle handles fat molecules in the bloodstream and how that relates to the ability of insulin to help the muscle use glucose, we will help understand the interaction between fat cells and muscle as it relates to diabetes-related diseases.
This study will evaluate obesity as a comorbidity in a population of patients with irritable bowel syndrome (IBS), and assess this cohort for vitamin D-deficiency. It will also determine whether alterations in the fecal microbiome and metaproteome, associated with vitamin D deficiency or other factors, underpin obesity-IBS comorbidity.
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- Defining overweight and obesity. Centers for Disease Control and Prevention. http://www.cdc.gov/obesity/adult/defining.html. Accessed March 9, 2015.
- Jensen MD, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults. Journal of the American College of Cardiology. 2014;63(25 Pt B):2985.
- Bray GA. Pathogenesis of obesity. http://www.uptodate.com/home. Accessed March 9, 2015.
- What are overweight and obesity? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/obe#. Accessed March 9, 2015.
- Bray GA. Obesity in adults: Etiology and natural history. http://www.uptodate.com/home. Accessed March 9, 2015.
- Bray GA. Obesity in adults: Health hazards. http://www.uptodate.com/home. Accessed March 9, 2015.
- Understanding adult overweight and obesity. National Institute of Diabetes and Digestive and Kidney Diseases. http://win.niddk.nih.gov/publications/understanding.htm. Accessed March 9, 2015.
- Papadakis MA, et al. Nutritional disorders. In: Current Medical Diagnosis & Treatment 2014. 53rd ed. New York, N.Y.: The McGraw-Hill Companies; 2014. http://www.accessmedicine.com. Accessed March 9, 2015
- Sacks F, et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. New England Journal of Medicine. 2009;360:859.
- Moyer VA, et al. Screening for and management of obesity in adults: U.S. Preventive Services Task Force recommendation statement. Annals of Internal Medicine. 2012;157:373.
- Bray GA. Obesity in adults: Drug therapy. http://www.uptodate.com/home. Accessed March 9, 2015.
- Greenberger NJ, et al. Treatment of obesity: The impact of bariatric surgery. In: Current Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy. 2nd ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com. Accessed March 9, 2015.
- Nelson DW, et al. Analysis of obesity-related outcomes and bariatric failure rates with the duodenal switch vs. gastric bypass for morbid obesity. Archives of Surgery. 2012;147:847.
- Weight control and complementary health practices: What the science says. National Center for Complementary and Integrative Health. http://nccih.nih.gov/health/providers/digest/weightloss-science. Accessed March 9, 2015.
- FDA approves first of kind device to treat obesity. U.S. Food and Drug Administration. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm430223.htm. Accessed Jan. 27, 2015.
- Pharmacological management of obesity: An Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology & Metabolism. 2015;100:342.
- Kim SB. Surgical management of severe obesity. http://www.uptodate.com/home. Accessed March 12, 2015.
- Ikramuddin S, et al. Effect of reversible intermittent intra-abdominal vagal nerve blockade on morbid obesity: The ReCharge randomized clinical trial. JAMA. 2014;312:915.
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