Below are current clinical trials.12 studies in Glioma
(open studies only).
Filter this list of studies by location, status and more.
This study is being done to:
1. Determine the best method of producing blood cells called "dendritic cells" which one day may be used to treat patients like you.
2. Process, grow and characterize tumors into cell cultures, to educate dendritic cells or the immune system to attack the tumor.
3. Analyze your immune system function.
RATIONALE: Vaccines made from a gene-modified virus may help the body build an effective immune response to kill tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of viral therapy in treating patients with recurrent glioblastoma multiforme.
The purpose of this study is to see if Magnetic Resonance Elastography (MRE) a recently developed imaging technique can be used to characterize and help stage glioma tumors and evaluate response to therapy.
The purpose of this study is to identify common genetic variants contributing to the risk of glioma. Evaluate gene-gene and gene-environmental interactions with strong biologic relevance to identify gene-gene and gene-environment interactions for glioma risk.
Scottsdale/Phoenix, Ariz., Rochester, Minn.
The purpose of this study is to combine MRI images with histologic and genetic analysis of cancer (from blood and tissue samples) to improve the overall accuracy of diagnosis and effectiveness of cancer treatment.
Jacksonville, Fla., Rochester, Minn.
Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving temozolomide alone, radiation followed by PCV, or temozolomide together with radiation therapy followed by temozolomide is more effective in treating anaplastic glioma.
Scottsdale/Phoenix, Ariz., Jacksonville, Fla., Rochester, Minn.
GRAIL is using deep sequencing of circulating cell-free nucleic acids (cfNAs) to develop assays to detect cancer early in blood. The purpose of this study is to collect biological samples from donors with a new diagnosis of cancer (blood and tumor tissue) and from donors who do not have a diagnosis of cancer (blood) in order to characterize the population heterogeneity in cancer and non-cancer subjects and to develop models for distinguishing cancer from non-cancer.
Scottsdale/Phoenix, Ariz., Rochester, Minn.
This randomized phase III trial studies armodafinil to see how well it works in reducing cancer-related fatigue in patients with high grade glioma. Armodafinil may help relieve fatigue in patients with high grade glioma.
The purpose of this study is to determine visual outcome in patients with neurofibromatosis type 1 (NF1). The study will also correlate visual outcome with the history of optic glioma based on previous MRI imaging and compare visual outcomes in treated and untreated adult NF1 patients with a history of optic glioma.
Rochester, Minn., Scottsdale/Phoenix, Ariz.
The purpose of this study is to use a nutrient called 18F-FDOPA and PET/CT scan to help determine where and how big the tumor is, as well as how aggressive the tumor is. This will help treating physicians to target diseased areas with higher than standard doses of radiation, in order to improve the effectiveness of radiation in this tumor.
June 29, 2016
- Central nervous system cancers. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed April 29, 2014.
- Winn RH. Youmans Neurological Surgery. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2011. http://www.clinicalkey.com. Accessed April 29, 2014.
- Stupp R, et al. High-grade malignant glioma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2010;21:v190. http://annonc.oxfordjournals.org/content/21/suppl_5/v190.full.pdf+html. Accessed Nov. 4, 2014.
- Brain SPOREs. National Institutes of Health. http://trp.cancer.gov/spores/brain.htm. Accessed April 29, 2014.
- Moynihan TJ (expert opinion). Mayo Clinic, Rochester, Minn. May 12, 2014.
- Glioma. American Brain Tumor Association. http://www.abta.org/brain-tumor-information/types-of-tumors/glioma.html. Accessed Nov. 6, 2014.
- Omuro A, et al. Glioblastoma and other malignant gliomas: A clinical review. Journal of the American Medical Association. 2013;310:1842. http://jama.jamanetwork.com/article.aspx?articleid=1764056. Accessed Nov. 4, 2014.
- Astrocystoma. American Brain Tumor Association. http://www.abta.org/brain-tumor-information/types-of-tumors/astrocytoma.html. Accessed Nov. 6, 2014.
- Ependymoma. American Brain Tumor Association. http://www.abta.org/brain-tumor-information/types-of-tumors/ependymoma.html. Accessed Nov. 6, 2014.
- What you need to know about brain tumors. National Cancer Institute. http://www.cancer.gov/cancertopics/wyntk/brain.pdf. Accessed Nov. 6, 2014.
- Armstrong TS, et al. Use of complementary and alternative medical therapy by patients with primary brain tumors. Current Neurology and Neuroscience Reports. 2008;8:264.
- Adult brain tumors treatment (PDQ): Health professional version. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/treatment/adultbrain/healthprofessional. Accessed Nov. 6, 2014.
- Taylor L. Diagnosis, treatment and prognosis of glioma: Five new things. Neurology: Clinical Practice. 2010:S28. http://www.neurology.org/content/75/18_Supplement_1/S28.full. Accessed Nov. 4, 2014.
- Rice EM. Decision Support System. Mayo Clinic, Rochester, Minn. Jan. 20, 2015.