Familial adenomatous polyposis

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Displaying 1-1 out of 1 doctors available

Last Name Initial: E

  1. Derek W. Ebner, M.D.

    Derek W. Ebner, M.D.

    1. Gastroenterologist
    1. Rochester, MN
    Areas of focus:

    Upper endoscopy, Colonoscopy, Balloon-assisted enteroscopy, Familial adenomatous polyposis, Hereditary cancer syndrome,... Colon polyps, Lynch syndrome

Research

Mayo Clinic doctors and scientists are involved in research to improve understanding, screening and care for people with familial adenomatous polyposis (FAP). Mayo Clinic maintains a Colon Cancer Family Registry that collects data and biospecimens from thousands of families to help identify genes linked to colorectal cancer risk and to understand how genetic changes lead to disease. Researchers examine genetic interactions, biomarkers and other factors that may influence cancer development and prevention.

Mayo Clinic researchers also have studied the incidence and risk factors for gastric cancer in people with FAP, aiming to refine surveillance strategies and guide early intervention in rare but serious outcomes. These findings may help shape future recommendations for screening beyond the colon in high-risk patients.

Clinical trials at Mayo Clinic have explored potential therapies for FAP, such as study of erlotinib to reduce polyp burden in the upper gastrointestinal tract and investigations into novel agents such as guselkumab to evaluate effects on polyp number and growth. Participation in these trials offers access to emerging approaches under scientific study.

Publications

See a list of publications about familial adenomatous polyposis (FAP) by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

Research Profiles

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By Mayo Clinic Staff

Familial adenomatous polyposis care at Mayo Clinic

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Diagnosis & treatmentCare at Mayo Clinic
May 12, 2026
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Familial adenomatous polyposis

Research: It's all about patients

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Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight.