Departments and specialties

Mayo Clinic has one of the largest and most experienced practices in the United States, with campuses in Arizona, Florida and Minnesota. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery.

Departments that treat this condition

Areas that research this condition



Mayo Clinic doctors trained in brain conditions (neurologists), brain surgery (neurosurgeons), nonsurgical treatments (neurosurgeons and neuroradiologists), brain imaging (neuroradiologists) and other professionals research brain aneurysm development, diagnosis, monitoring, management and treatment.

Researchers study which brain aneurysms need to be treated and which can be monitored. Mayo Clinic researchers also study management of subarachnoid hemorrhages. Learn more about research in neurology and neurosurgery.

Mayo Clinic research of note includes:

  • Flow diverter research. Mayo Clinic researchers collaborated on the Pipeline for Uncoilable or Failed Aneurysms (PUFS) study and led the Aneurysm Study of Pipeline in an Observational Registry (ASPIRE) study, both of which assessed the feasibility, safety and efficacy of flow diverters for the treatment of unruptured brain aneurysms.

    Flow diverters are special devices which, when placed across the aneurysm, will redirect flow away from the aneurysm. In the vast majority of patients, placing flow diverters eventually leads to complete obliteration of the aneurysm. Such diverters are threaded to the aneurysm site through a catheter placed in the groin area.

    Mayo physicians also conduct related research into topics such as flow diverter effectiveness in recipients as well as the effectiveness of particular approaches, such as coiling followed by flow diversion to treat ruptured complex and large/giant ruptured cerebral aneurysms, or the potential efficacy of combined coiling and anti-inflammatory medications, to help prevent delayed aneurysm ruptures.

  • ISUIA study. The International Study of Unruptured Intracranial Aneurysms (ISUIA) indicated that aneurysm size and location were predictors of rupture in a cohort of people with an unruptured aneurysm. The research, led by Mayo Clinic and sponsored by the National Institutes of Health, helped doctors more reliably determine brain aneurysms needing immediate treatment.
  • Other large-scale studies. Mayo Clinic researchers examine questions such as the incidence and predictors of complications after surgical clipping of unruptured intracranial aneurysms. The aim in the post-surgical clipping study was to help recognize patients at greater risk of post-surgical complications, hopefully leading to appropriate treatment strategy changes for such patients.

    Mayo Clinic physicians have also examined the comparative effectiveness of endovascular coil embolization versus clipping for ruptured intracranial aneurysms. Additionally, Mayo researchers collaborated on a multicenter study on stent-assisted coiling versus coiling alone in poor-grade ruptured intracranial aneurysms.

  • Aneurysm genetics. Mayo Clinic researchers collaborated in the Familial Intracranial Aneurysm Study, which is clarifying the underlying genetic cause for brain aneurysms and frequency of aneurysm detection in the setting of a family history of aneurysm.
  • Aspirin study. Data from the International Study of Unruptured Intracranial Aneurysms, led by Mayo Clinic and funded by the National Institutes of Health, suggests that people who take aspirin in the setting of an unruptured intracranial aneurysm could possibly be at lower risk of aneurysm rupture. This research is ongoing.

Mayo Clinic publications

See a list of publications on brain aneurysms by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

Read more about intracranial aneurysm management.