James L. Kirkland, M.D., Ph.D.

  1. Endocrinologist
  2. Geriatrician
  3. Internist
  1. Bonnes SLR, Strauss T, Palmer AK, Hurt RT, Island L, Goshen A, Wang LYT, Kirkland JL, Bischof E, Maier AB. Establishing healthy longevity clinics in publicly funded hospitals. Geroscience. 2024 Mar 21 [Epub ahead of print]
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  2. Suda M, Paul KH, Tripathi U, Minamino T, Tchkonia T, Kirkland JL. Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction. Endocr Rev. 2024 Mar 19 [Epub ahead of print]
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  3. Hajj-Boutros G, Faust A, Muscedere J, Kim P, Abumrad N, Chevalier S, Aubertin-Leheudre M, Bergman H, Bowdish D, Burford J, Carrington-Lawrence S, Cote H, Dawe DE, Barreto PS, Farrelly C, Fowler R, Gouspillou G, Harrington L, Lautrup S, Howlett S, Imani M, Kirkland J, Kuchel G, Mallette FA, Morais JA, Newman JC, Pullman D, Sierra F, Van Raamsdonk J, Watt J, Rylett RJ, Duque G. Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions. J Gerontol A Biol Sci Med Sci. 2024 Mar 15 [Epub ahead of print]
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  4. Iske J, Roesel MJ, Martin F, Schroeter A, Matsunaga T, Maenosono R, Tripathi U, Xiao Y, Nian Y, Caldarone BJ, Vondran FWR, Sage PT, Azuma H, Abdi R, Elkhal A, Pirtskhalava T, Tchkonia T, Kirkland JL, Zhou H, Tullius SG. Transplanting old organs promotes senescence in young recipients. Am J Transplant. 2024 Mar; 24 (3):391-405 Epub 2023 Oct 31
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  5. Chaib S, Lopez-Dominguez JA, Lalinde-Gutierrez M, Prats N, Marin I, Boix O, Garcia-Garijo A, Meyer K, Munoz MI, Aguilera M, Mateo L, Stephan-Otto Attolini C, Llanos S, Perez-Ramos S, Escorihuela M, Al-Shahrour F, Cash TP, Tchkonia T, Kirkland JL, Abad M, Gros A, Arribas J, Serrano M. The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nat Cancer. 2024 Mar; 5 (3):448-462 Epub 2024 Jan 24
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  6. Stojakovic A, Trushin S, Sheu A, Khalili L, Chang SY, Li X, Christensen T, Salisbury JL, Geroux RE, Gateno B, Flannery PJ, Dehankar M, Funk CC, Wilkins J, Stepanova A, O'Hagan T, Galkin A, Nesbitt J, Zhu X, Tripathi U, Macura S, Tchkonia T, Pirtskhalava T, Kirkland JL, Kudgus RA, Schoon RA, Reid JM, Yamazaki Y, Kanekiyo T, Zhang S, Nemutlu E, Dzeja P, Jaspersen A, Kwon YIC, Lee MK, Trushina E. Author Correction: Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice. Commun Biol. 2024 Feb 26; 7 (1):234
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  7. Suda M, Katsuumi G, Tchkonia T, Kirkland JL, Minamino T. Potential Clinical Implications of Senotherapies for Cardiovascular Disease. Circ J. 2024 Feb 22; 88 (3):277-284 Epub 2023 Oct 26
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  8. Nath KA, Singh RD, Croatt AJ, Ackerman AW, Grande JP, O'Brien DR, Garovic VD, Adams CM, Tchkonia T, Kirkland JL. Induction of p16Ink4a Gene Expression in Heme Protein-Induced Acute Kidney Injury and by Heme: Pathophysiologic Implications. Kidney360. 2024 Feb 21 [Epub ahead of print]
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  9. Yu GT, Gomez PT, Prata LG, Lehman JS, Tchkonia T, Kirkland JL, Meves A, Wyles SP. Clinicopathological and cellular senescence biomarkers in chronic stalled wounds. Int J Dermatol. 2024 Feb 13 [Epub ahead of print]
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  10. Zhu Y, Anastasiadis ZP, Espindola Netto JM, Evans T, Tchkonia T, Kirkland JL. Past and Future Directions for Research on Cellular Senescence. Cold Spring Harb Perspect Med. 2024 Feb 1; 14 (2) Epub 2024 Feb 01
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  11. Harrison DE, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, Flurkey K, Ginsburg BC, Murrell MD, Javors MA, Lopez-Cruzan M, Nelson JF, Willcox BJ, Allsopp R, Watumull DM, Watumull DG, Cortopassi G, Kirkland JL, Tchkonia T, Choi YG, Yousefzadeh MJ, Robbins PD, Mitchell JR, Acar M, Sarnoski EA, Bene MR, Salmon A, Kumar N, Miller RA. Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used. Geroscience. 2024 Feb; 46 (1):795-816 Epub 2023 Dec 02
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  12. Yu GT, Monie DD, Khosla S, Tchkonia T, Kirkland JL, Wyles SP. Mapping cellular senescence networks in human diabetic foot ulcers. Geroscience. 2024 Feb; 46 (1):1071-1082 Epub 2023 June 29
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  13. Justice JN, Leng XI, LeBrasseur NK, Tchkonia T, Kirkland JL, Mitin N, Liu Y, Kritchevsky SB, Nicklas BJ, Ding J. Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the Senescence-Associated Secretome in Middle-Aged and Older Adults With Obesity and Prediabetes in an 18-Week Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci. 2024 Jan 1; 79 (1)
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  14. Wyles SP, Carruthers JD, Dashti P, Yu G, Yap JQ, Gingery A, Tchkonia T, Kirkland J. Cellular Senescence in Human Skin Aging: Leveraging Senotherapeutics. Gerontology. 2024; 70 (1):7-14 Epub 2023 Oct 25
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  15. Lin Y, Postma DF, Steeneken LS, Melo Dos Santos LS, Kirkland JL, Espindola-Netto JM, Tchkonia T, Borghesan M, Bouma HR, Demaria M. Circulating monocytes expressing senescence-associated features are enriched in COVID-19 patients with severe disease. Aging Cell. 2023 Dec; 22 (12):e14011 Epub 2023 Nov 15
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  16. Riviere-Cazaux C, Carlstrom LP, Neth BJ, Olson IE, Rajani K, Rahman M, Ikram S, Mansour MA, Mukherjee B, Warrington AE, Short SC, von Zglinicki T, Brown DA, Burma S, Tchkonia T, Schafer MJ, Baker DJ, Kizilbash SH, Kirkland JL, Burns TC. An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence. NPJ Precis Oncol. 2023 Nov 29; 7 (1):126
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  17. Alogna A, Koepp KE, Sabbah M, Espindola Netto JM, Jensen MD, Kirkland JL, Lam CSP, Obokata M, Petrie MC, Ridker PM, Sorimachi H, Tchkonia T, Voors A, Redfield MM, Borlaug BA. Interleukin-6 in Patients With Heart Failure and Preserved Ejection Fraction. JACC Heart Fail. 2023 Nov; 11 (11):1549-1561 Epub 2023 Aug 09
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  18. Gonzales MM, Garbarino VR, Kautz TF, Palavicini JP, Lopez-Cruzan M, Dehkordi SK, Mathews JJ, Zare H, Xu P, Zhang B, Franklin C, Habes M, Craft S, Petersen RC, Tchkonia T, Kirkland JL, Salardini A, Seshadri S, Musi N, Orr ME. Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial. Nat Med. 2023 Oct; 29 (10):2481-2488 Epub 2023 Sept 07
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  19. Langhi Prata LGP, Tchkonia T, Kirkland JL. Cell senescence, the senescence-associated secretory phenotype, and cancers. PLoS Biol. 2023 Sep; 21 (9):e3002326 Epub 2023 Sept 21
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  20. Rolland Y, Sierra F, Ferrucci L, Barzilai N, De Cabo R, Mannick J, Oliva A, Evans W, Angioni D, De Souto Barreto P, Raffin J, Vellas B, Kirkland JL, G.C.T-TF group. Challenges in developing Geroscience trials. Nat Commun. 2023 Aug 19; 14 (1):5038
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  21. Forman DE, Kuchel GA, Newman JC, Kirkland JL, Volpi E, Taffet GE, Barzilai N, Pandey A, Kitzman DW, Libby P, Ferrucci L. Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease: JACC Scientific Statement. J Am Coll Cardiol. 2023 Aug 15; 82 (7):631-647 Epub 2023 June 28
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  22. Singh M, El Sabbagh A, Lewis BR, Kanwar A, Terzic CM, Al-Hijji MA, Behfar A, Kirkland JL. Clinical Significance of Biological Age in Patients Undergoing Percutaneous Coronary Intervention. Mayo Clin Proc. 2023 Aug; 98(8):1137-1152.
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  23. Danczak-Pazdrowska A, Gornowicz-Porowska J, Polanska A, Krajka-Kuzniak V, Stawny M, Gostynska A, Rubis B, Nourredine S, Ashiqueali S, Schneider A, Tchkonia T, Wyles SP, Kirkland JL, Masternak MM. Cellular senescence in skin-related research: Targeted signaling pathways and naturally occurring therapeutic agents. Aging Cell. 2023 Jun; 22 (6):e13845 Epub 2023 Apr 11
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  24. Murphy J, Tam BT, Kirkland JL, Tchkonia T, Giorgadze N, Pirtskhalava T, Tsoukas MA, Morais JA, Santosa S. Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss. Obesity (Silver Spring). 2023 Jun; 31 (6):1610-1619 Epub 2023 May 17
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  25. Kandhaya-Pillai R, Miro-Mur F, Alijotas-Reig J, Tchkonia T, Schwartz S, Kirkland JL, Oshima J. Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex. Aging (Albany NY). 2023 May 22; 15 (10):4012-4034
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  26. Samakkarnthai P, Saul D, Zhang L, Aversa Z, Doolittle ML, Sfeir JG, Kaur J, Atkinson EJ, Edwards JR, Russell GG, Pignolo RJ, Kirkland JL, Tchkonia T, Niedernhofer LJ, Monroe DG, Lebrasseur NK, Farr JN, Robbins PD, Khosla S. In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers. Aging (Albany NY). 2023 May 7; 15 (9):3331-3355 Epub 2023 May 07
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  27. Suda M, Paul KH, Minamino T, Miller JD, Lerman A, Ellison-Hughes GM, Tchkonia T, Kirkland JL. Senescent Cells: A Therapeutic Target in Cardiovascular Diseases. Cells. 2023 May 2; 12 (9) Epub 2023 May 02
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  28. Wyles SP, Dashti P, Pirtskhalava T, Tekin B, Inman C, Gomez LS, Lagnado AB, Prata L, Jurk D, Passos JF, Tchkonia T, Kirkland JL. A chronic wound model to investigate skin cellular senescence. Aging (Albany NY). 2023 Apr 21; 15(8):2852-2862.
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  29. Farr JN, Saul D, Doolittle ML, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Weivoda M, Ikeno Y, Pignolo RJ, Niedernhofer LJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Local senolysis in aged mice only partially replicates the benefits of systemic senolysis. J Clin Invest. 2023 Apr 17; 133(8).
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  30. Ma X, Zhang Y, Zhang Y, Zhang X, Huang Y, He K, Chen C, Hao J, Zhao D, LeBrasseur NK, Kirkland JL, Chini EN, Wei Q, Ling K, Hu J. A stress-induced cilium-to-PML-NB route drives senescence initiation. Nat Commun. 2023 Apr 3; 14 (1):1840 Epub 2023 Apr 03
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  31. Nambiar A, Kellogg D 3rd, Justice J, Goros M, Gelfond J, Pascual R, Hashmi S, Masternak M, Prata L, LeBrasseur N, Limper A, Kritchevsky S, Musi N, Tchkonia T, Kirkland J. Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability. EBioMedicine. 2023 Apr; 90:104481 Epub 2023 Feb 28
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  32. Schmitt CA, Tchkonia T, Niedernhofer LJ, Robbins PD, Kirkland JL, Lee S. COVID-19 and cellular senescence. Nat Rev Immunol. 2023 Apr; 23 (4):251-263 Epub 2022 Oct 05
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  33. Kirkland JL. Tumor dormancy and disease recurrence. Cancer Metastasis Rev. 2023 Mar; 42 (1):9-12
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  34. Millar CL, Iloputaife I, Baldyga K, Kuo J, Tchkonia T, Kirkland JL, Travison TG, Lipsitz LA. Rationale and design of STAMINA: Senolytics to alleviate mobility issues and neurological impairments in aging, a geroscience feasibility study. Translational Medicine of Aging. 2023; 7:109-17
  35. Shafqat A, Khan S, Omer MH, Niaz M, Albalkhi I, AlKattan K, Yaqinuddin A, Tchkonia T, Kirkland JL, Hashmi SK. Cellular senescence in brain aging and cognitive decline. Front Aging Neurosci. 2023; 15:1281581 Epub 2023 Nov 23
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  36. Palmer AK, Tchkonia T, Kirkland JL. Targeting cellular senescence in metabolic disease. Mol Metab. 2022 Dec; 66:101601 Epub 2022 Sept 16
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  37. Singh RD, Croatt AJ, Ackerman AW, Grande JP, Trushina E, Salisbury JL, Christensen TA, Adams CM, Tchkonia T, Kirkland JL, Nath KA. Prominent Mitochondrial Injury as an Early Event in Heme Protein-Induced Acute Kidney Injury. Kidney360. 2022 Oct 27; 3 (10):1672-1682 Epub 2022 Aug 15
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  38. Huang W, Hickson LJ, Eirin A, Kirkland JL, Lerman LO. Cellular senescence: the good, the bad and the unknown. Nat Rev Nephrol. 2022 Oct; 18 (10):611-627 Epub 2022 Aug 03
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  39. Sun Y, Li Q, Kirkland JL. Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging. Life Med. 2022 Oct; 1 (2):103-119 Epub 2022 Aug 09
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  40. Wyles SP, Tchkonia T, Kirkland JL. Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical Translation. Plast Reconstr Surg. 2022 Oct 1; 150:20S-26S Epub 2021 Sept 28
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  41. Zhang X, Pearsall VM, Carver CM, Atkinson EJ, Clarkson BDS, Grund EM, Baez-Faria M, Pavelko KD, Kachergus JM, White TA, Johnson RK, Malo CS, Gonzalez-Suarez AM, Ayasoufi K, Johnson KO, Tritz ZP, Fain CE, Khadka RH, Ogrodnik M, Jurk D, Zhu Y, Tchkonia T, Revzin A, Kirkland JL, Johnson AJ, Howe CL, Thompson EA, LeBrasseur NK, Schafer MJ. Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance. Nat Commun. 2022 Sep 27; 13 (1):5671 Epub 2022 Sept 27
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  42. Meijnikman AS, van Olden CC, Aydin O, Herrema H, Kaminska D, Lappa D, Mannisto V, Tremaroli V, Olofsson LE, de Brauw M, van de Laar A, Verheij J, Gerdes VEA, Schwartz TW, Nielsen J, Backhed F, Pajukanta P, Pihlajamaki J, Tchkonia T, Kirkland JL, Kuipers F, Nieuwdorp M, Groen AK. Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts. Diabetes. 2022 Sep 1; 71 (9):1929-1936
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  43. Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK, Pignolo RJ, Robbins PD, Niedernhofer LJ, Ikeno Y, Jurk D, Passos JF, Hickson LJ, Xue A, Monroe DG, Tchkonia T, Kirkland JL, Farr JN, Khosla S. A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nat Commun. 2022 Aug 16; 13 (1):4827
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  44. Chaib S, Tchkonia T, Kirkland JL. Cellular senescence and senolytics: the path to the clinic. Nat Med. 2022 Aug; 28(8):1556-1568. Epub 2022 Aug 11.
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  45. Baboota RK, Rawshani A, Bonnet L, Li X, Yang H, Mardinoglu A, Tchkonia T, Kirkland JL, Hoffmann A, Dietrich A, Boucher J, Bluher M, Smith U. BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH. Nat Metab. 2022 Aug; 4 (8):1007-1021 Epub 2022 Aug 22
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  46. Ishaq A, Tchkonia T, Kirkland JL, Siervo M, Saretzki G. Palmitate induces DNA damage and senescence in human adipocytes in vitro that can be alleviated by oleic acid but not inorganic nitrate. Exp Gerontol. 2022 Jun 15; 163:111798 Epub 2022 Apr 04
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  47. Rahman M, Olson I, Mansour M, Carlstrom LP, Sutiwisesak R, Saber R, Rajani K, Warrington AE, Howard A, Schroeder M, Chen S, Decker PA, Sananikone EF, Zhu Y, Tchkonia T, Parney IF, Burma S, Brown D, Rodriguez M, Sarkaria JN, Kirkland JL, Burns TC. Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition. Mol Cancer Res. 2022 Jun 3; 20 (6):938-948
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  48. Kim SR, Jiang K, Chen X, Puranik AS, Zhu XY, Lerman A, Tchkonia T, Kirkland JL, Lerman LO. Selective kidney targeting increases the efficacy of mesenchymal stromal/stem cells for alleviation of murine stenotic-kidney senescence and damage. J Tissue Eng Regen Med. 2022 Jun; 16 (6):550-558 Epub 2022 Mar 23
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  49. Kandhaya-Pillai R, Yang X, Tchkonia T, Martin GM, Kirkland JL, Oshima J. TNF-alpha/IFN-gamma synergy amplifies senescence-associated inflammation and SARS-CoV-2 receptor expression via hyper-activated JAK/STAT1. Aging Cell. 2022 Jun; 21 (6):e13646 Epub 2022 May 30
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  50. Chandra A, Lagnado AB, Farr JN, Doolittle M, Tchkonia T, Kirkland JL, LeBrasseur NK, Robbins PD, Niedernhofer LJ, Ikeno Y, Passos JF, Monroe DG, Pignolo RJ, Khosla S. Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity. Aging Cell. 2022 May; 21 (5):e13602 Epub 2022 Apr 01
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  51. Tung EE, Weavers KM, Kirkland JL, Pignolo RJ. Bridging the geroscience chasm between bench and bedside. Gerontol Geriatr Educ. 2022 Apr-Jun; 43 (2):250-256 Epub 2020 Oct 09
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  52. Zhu Y, Prata LGPL, Gerdes EOW, Netto JME, Pirtskhalava T, Giorgadze N, Tripathi U, Inman CL, Johnson KO, Xue A, Palmer AK, Chen T, Schaefer K, Justice JN, Nambiar AM, Musi N, Kritchevsky SB, Chen J, Khosla S, Jurk D, Schafer MJ, Tchkonia T, Kirkland JL. Orally-active, clinically-translatable senolytics restore alpha-Klotho in mice and humans. EBioMedicine. 2022 Mar; 77:103912 Epub 2022 Mar 13
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  53. Wissler Gerdes EO, Vanichkachorn G, Verdoorn BP, Hanson GJ, Joshi AY, Murad MH, Rizza SA, Hurt RT, Tchkonia T, Kirkland JL. Role of senescence in the chronic health consequences of COVID-19. Transl Res. 2022 Mar; 241:96-108 Epub 2021 Oct 22
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  54. Masters MC, Landay AL, Robbins PD, Tchkonia T, Kirkland JL, Kuchel GA, Niedernhofer LJ, Palella FJ. Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach. J Acquir Immune Defic Syndr. 2022 Feb 1; 89 (Suppl 1):S34-S46
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  55. Nunes ADC, Weigl M, Schneider A, Noureddine S, Yu L, Lahde C, Saccon TD, Mitra K, Beltran E, Grillari J, Kirkland JL, Tchkonia T, Robbins PD, Masternak MM. miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes. Geroscience. 2022 Feb; 44 (1):503-518 Epub 2021 Nov 25
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  56. Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, Ermolaeva M, Ewald CY, Ferrucci L, Florian MC, Fortney K, Freund A, Georgievskaya A, Gladyshev VN, Glass D, Golato T, Gorbunova V, Hoejimakers J, Houtkooper RH, Jager S, Jaksch F, Janssens G, Jensen MB, Kaeberlein M, Karsenty G, de Keizer P, Kennedy B, Kirkland JL, Kjaer M, Kroemer G, Lee KF, Lemaitre JM, Liaskos D, Longo VD, Lu YX, MacArthur MR, Maier AB, Manakanatas C, Mitchell SJ, Moskalev A, Niedernhofer L, Ozerov I, Partridge L, Passegue E, Petr MA, Peyer J, Radenkovic D, Rando TA, Rattan S, Riedel CG, Rudolph L, Ai R, Serrano M, Schumacher B, Sinclair DA, Smith R, Suh Y, Taub P, Trapp A, Trendelenburg AU, Valenzano DR, Verburgh K, Verdin E, Vijg J, Westendorp RGJ, Zonari A, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. Meeting Report: Aging Research and Drug Discovery. Aging (Albany NY). 2022 Jan 28; 14 (2):530-543
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  57. Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Prata LGPL, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kshitiz Kshitiz, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M. Targeting p21(Cip1) highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Cell Metab. 2022 Jan 4; 34 (1):75-89.e8 Epub 2021 Nov 22
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  58. Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Langhi Prata LGP, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kshitiz Kshitiz, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M. Targeting p21(Cip1) highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Cell Metab. 2022 Jan 4; 34 (1):186
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  59. Gonzales MM, Garbarino VR, Marques Zilli E, Petersen RC, Kirkland JL, Tchkonia T, Musi N, Seshadri S, Craft S, Orr ME. Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial. J Prev Alzheimers Dis. 2022; 9 (1):22-29
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  60. DeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ, Milman S, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. Extending human healthspan and longevity: a symposium report. Ann N Y Acad Sci. 2022 Jan; 1507 (1):70-83 Epub 2021 Sept 08
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  61. Chaib S, Tchkonia T, Kirkland JL. Obesity, Senescence, and Senolytics. Handb Exp Pharmacol. 2022; 274:165-180
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  62. Xu Q, Fu Q, Li Z, Liu H, Wang Y, Lin X, He R, Zhang X, Ju Z, Campisi J, Kirkland JL, Sun Y. The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice. Nat Metab. 2021 Dec; 3 (12):1706-1726 Epub 2021 Dec 06
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  63. Salaami O, Kuo CL, Drake MT, Kuchel GA, Kirkland JL, Pignolo RJ. Antidiabetic Effects of the Senolytic Agent Dasatinib. Mayo Clin Proc. 2021 Dec; 96 (12):3021-3029 Epub 2021 Nov 09
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  64. Wissler Gerdes EO, Misra A, Netto JME, Tchkonia T, Kirkland JL. Strategies for late phase preclinical and early clinical trials of senolytics. Mech Ageing Dev. 2021 Dec; 200:111591 Epub 2021 Oct 23
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  65. Verdoorn BP, Evans TK, Hanson GJ, Zhu Y, Langhi Prata LGP, Pignolo RJ, Atkinson EJ, Wissler-Gerdes EO, Kuchel GA, Mannick JB, Kritchevsky SB, Khosla S, Rizza SA, Walston JD, Musi N, Lipsitz LA, Kiel DP, Yung R, LeBrasseur NK, Singh RJ, McCarthy T, Puskarich MA, Niedernhofer LJ, Robbins PD, Sorenson M, Tchkonia T, Kirkland JL. Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era. J Am Geriatr Soc. 2021 Nov; 69 (11):3023-3033 Epub 2021 Aug 20
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  66. Saccon TD, Nagpal R, Yadav H, Cavalcante MB, Nunes ADC, Schneider A, Gesing A, Hughes B, Yousefzadeh M, Tchkonia T, Kirkland JL, Niedernhofer LJ, Robbins PD, Masternak MM. Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice. J Gerontol A Biol Sci Med Sci. 2021 Oct 13; 76 (11):1895-1905
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  67. Wang B, Wang L, Gasek NS, Zhou Y, Kim T, Guo C, Jellison ER, Haynes L, Yadav S, Tchkonia T, Kuchel GA, Kirkland JL, Xu M. An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo. Nat Aging. 2021 Oct; 1 (10):962-973 Epub 2021 Oct 07
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  68. Gasek NS, Kuchel GA, Kirkland JL, Xu M. Strategies for Targeting Senescent Cells in Human Disease. Nat Aging. 2021 Oct; 1 (10):870-879 Epub 2021 Oct 07
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  69. Prasanna PG, Citrin DE, Hildesheim J, Ahmed MM, Venkatachalam S, Riscuta G, Xi D, Zheng G, Deursen JV, van Deursen J, Goronzy J, Kron SJ, Anscher MS, Sharpless NE, Campisi J, Brown SL, Niedernhofer LJ, O'Loghlen A, Georgakilas AG, Paris F, Gius D, Gewirtz DA, Schmitt CA, Abazeed ME, Kirkland JL, Richmond A, Romesser PB, Lowe SW, Gil J, Mendonca MS, Burma S, Zhou D, Coleman CN. Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy. J Natl Cancer Inst. 2021 Oct 1; 113 (10):1285-1298
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  70. Tripathi U, Nchioua R, Prata LGPL, Zhu Y, Gerdes EOW, Giorgadze N, Pirtskhalava T, Parker E, Xue A, Espindola-Netto JM, Stenger S, Robbins PD, Niedernhofer LJ, Dickinson SL, Allison DB, Kirchhoff F, Sparrer KMJ, Tchkonia T, Kirkland JL. SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3. Aging (Albany NY). 2021 Sep 16; 13 (18):21838-21854 Epub 2021 Sept 16
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  147. Kandhaya-Pillai R, Miro-Mur F, Alijotas-Reig J, Tchkonia T, Kirkland JL, Schwartz S. TNFalpha-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion. Aging (Albany NY). 2017 Nov 22; 9 (11):2411-2435
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  172. Sagar G, Sah RP, Javeed N, Dutta SK, Smyrk TC, Lau JS, Giorgadze N, Tchkonia T, Kirkland JL, Chari ST, Mukhopadhyay D. Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue. Gut. 2016 Jul; 65 (7):1165-74 Epub 2015 Apr 28
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  185. Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB, Hirsova P, Krishnan A, Liedtke C, Trautwein C, Finnberg N, El-Deiry WS, Kirkland JL, Gores GJ. TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess. J Hepatol. 2015 May; 62 (5):1156-63 Epub 2014 Nov 28
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  188. Escande C, Nin V, Pirtskhalava T, Chini CC, Tchkonia T, Kirkland JL, Chini EN. Deleted in breast cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype. Diabetes. 2015 Jan; 64 (1):12-22 Epub 2014 July 22
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  193. Poland GA, Ovsyannikova IG, Kennedy RB, Lambert ND, Kirkland JL. A systems biology approach to the effect of aging, immunosenescence and vaccine response. Curr Opin Immunol. 2014 Aug; 29:62-8 Epub 2014 May 13
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  195. Zhu Y, Armstrong JL, Tchkonia T, Kirkland JL. Cellular senescence and the senescent secretory phenotype in age-related chronic diseases. Curr Opin Clin Nutr Metab Care. 2014 Jul; 17 (4):324-8
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  196. Wong S, Kirkland JL, Schwanz HA, Simmons AL, Hamilton JA, Corkey BE, Guo W. Effects of thiol antioxidant beta-mercaptoethanol on diet-induced obese mice. Life Sci. 2014 Jun 27; 107 (1-2):32-41 Epub 2014 May 05
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  198. Tran D, Bergholz J, Zhang H, He H, Wang Y, Zhang Y, Li Q, Kirkland JL, Xiao ZX. Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence. Aging Cell. 2014; 13(4):669-78.
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  199. Conover CA, Harstad SL, Tchkonia T, Kirkland JL. Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet. Am J Physiol Endocrinol Metab. 2013 Nov 1; 305 (9):E1145-53 Epub 2013 Sept 17
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  204. Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DE. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2013 Jan; 68(1):6-16. Epub 2012 Mar 26
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  205. Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR. Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab. 2012 Sep 5; 16(3):336-47.
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  206. Lithgow GJ, Lord JM, Kirkland JL. Translating longevity research into healthspan. Longev Healthspan. 2012; 1:1 Epub 2012 Sept 03
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  207. Guo W, Wong S, Li M, Liang W, Liesa M, Serra C, Jasuja R, Bartke A, Kirkland JL, Shirihai O, Bhasin S. Testosterone plus low-intensity physical training in late life improves functional performance, skeletal muscle mitochondrial biogenesis, and mitochondrial quality control in male mice. PLoS ONE. 2012; 7(12):e51180.
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  208. Guo W, Li Y, Liang W, Wong S, Apovian C, Kirkland JL, Corkey BE. Beta-mecaptoethanol suppresses inflammation and induces adipogenic differentiation in 3T3-F442A murine preadipocytes. PLoS One. 2012; 7(7):e40958. Epub 2012 Jul 23.
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  209. Karagiannides I, Bakirtzi K, Kokkotou E, Stavrakis D, Margolis KG, Thomou T, Giorgadze N, Kirkland JL, Pothoulakis C. Role of substance P in the regulation of glucose metabolism via insulin signaling-associated pathways. Endocrinology. 2011 Dec; 152(12):4571-80. Epub 2011 Oct 18.
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  210. Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 2011 Nov 2; 479 (7372):232-6 Epub 2011 Nov 02
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  211. Karagiannides I, Stavrakis D, Bakirtzi K, Kokkotou E, Pirtskhalava T, Nayeb-Hashemi H, Bowe C, Bugni JM, Nuno M, Lu B, Gerard NP, Leeman SE, Kirkland JL, Pothoulakis C. Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action. Endocrinology. 2011 Jun; 152(6):2197-205. Epub 2011 Apr 05.
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  217. Zaragosi LE, Wdziekonski B, Villageois P, Keophiphath M, Maumus M, Tchkonia T, Bourlier V, Mohsen-Kanson T, Ladoux A, Elabd C, Scheideler M, Trajanoski Z, Takashima Y, Amri EZ, Lacasa D, Sengenes C, Ailhaud G, Clement K, Bouloumie A, Kirkland JL, Dani C. Activin a plays a critical role in proliferation and differentiation of human adipose progenitors. Diabetes. 2010 Oct; 59(10):2513-21. Epub 2010 Jun 08.
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  220. Cleveland-Donovan K, Maile LA, Tsiaras WG, Tchkonia T, Kirkland JL, Boney CM. IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects. Endocrinology. 2010 Aug; 151(8):3752-63. Epub 2010 Jun 16.
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  222. Gross K, Karagiannides I, Thomou T, Koon HW, Bowe C, Kim H, Giorgadze N, Tchkonia T, Pirtskhalava T, Kirkland JL, Pothoulakis C. Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways. Am J Physiol Gastrointest Liver Physiol. 2009 May; 296(5):G1012-9. Epub 2009 Mar 12.
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  223. Kirkland JL, Peterson C. Healthspan, translation, and new outcomes for animal studies of aging. J Gerontol A Biol Sci Med Sci. 2009 Feb; 64 (2):209-12 Epub 2009 Feb 05
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  224. Gupta V, Bhasin S, Guo W, Singh R, Miki R, Chauhan P, Choong K, Tchkonia T, Lebrasseur NK, Flanagan JN, Hamilton JA, Viereck JC, Narula NS, Kirkland JL, Jasuja R. Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes. Mol Cell Endocrinol. 2008 Dec 16; 296(1-2):32-40. Epub 2008 Aug 28.
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  225. Vitseva OI, Tanriverdi K, Tchkonia TT, Kirkland JL, McDonnell ME, Apovian CM, Freedman J, Gokce N. Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue. Obesity (Silver Spring). 2008 May; 16: (5)932-7.
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  226. Guo W, Flanagan J, Jasuja R, Kirkland J, Jiang L, Bhasin S. The effects of myostatin on adipogenic differentiation of human bone marrow-derived mesenchymal stem cells are mediated through cross-communication between Smad3 and Wnt/beta-catenin signaling pathways. J Biol Chem. 2008 Apr 4; 283(14):9136-45. Epub 2008 Jan 18.
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  227. Tchkonia T, Pirtskhalava T, Thomou T, Cartwright MJ, Wise B, Karagiannides I, Shpilman A, Lash TL, Becherer JD, Kirkland JL. Increased TNFalpha and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1810-9. Epub 2007 Oct 02.
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  228. Guo W, Bigornia S, Leizerman I, Xie W, McDonnell M, Clemente K, Pirtskhalava T, Kirkland JL, Gokce N, Corkey BE, Sullivan LM, Apovian CM. New scanning electron microscopic method for determination of adipocyte size in humans and mice. Obesity (Silver Spring). 2007 Jul; 15(7):1657-65.
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  229. Han JR, Deng B, Sun J, Chen CG, Corkey BE, Kirkland JL, Ma J, Guo W. Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects. Metabolism. 2007 Jul; 56(7):985-91.
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  230. Cartwright MJ, Tchkonia T, Kirkland JL. Aging in adipocytes: potential impact of inherent, depot-specific mechanisms. Exp Gerontol. 2007 Jun; 42(6):463-71. Epub 2007 Mar 25.
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  231. Guo W, Pirtskhalava T, Tchkonia T, Xie W, Thomou T, Han J, Wang T, Wong S, Cartwright A, Hegardt FG, Corkey BE, Kirkland JL. Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity. Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1041-51. Epub 2006 Dec 05.
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  232. Tchkonia T, Lenburg M, Thomou T, Giorgadze N, Frampton G, Pirtskhalava T, Cartwright A, Cartwright M, Flanagan J, Karagiannides I, Gerry N, Forse RA, Tchoukalova Y, Jensen MD, Pothoulakis C, Kirkland JL. Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E298-307. Epub 2006 Sep 19.
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  233. Tchkonia T, Giorgadze N, Pirtskhalava T, Thomou T, DePonte M, Koo A, Forse RA, Chinnappan D, Martin-Ruiz C, von Zglinicki T, Kirkland JL. Fat depot-specific characteristics are retained in strains derived from single human preadipocytes. Diabetes. 2006 Sep; 55(9):2571-8.
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  234. Karagiannides I, Thomou T, Tchkonia T, Pirtskhalava T, Kypreos KE, Cartwright A, Dalagiorgou G, Lash TL, Farmer SR, Timchenko NA, Kirkland JL. Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging. J Biol Chem. 2006 Aug 11; 281(32):23025-33. Epub 2006 Jun 05.
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  235. Karagiannides I, Kokkotou E, Tansky M, Tchkonia T, Giorgadze N, O'Brien M, Leeman SE, Kirkland JL, Pothoulakis C. Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5207-12. Epub 2006 Mar 20.
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  236. Xie W, Hamilton JA, Kirkland JL, Corkey BE, Guo W. Oleate-induced formation of fat cells with impaired insulin sensitivity. Lipids. 2006 Mar; 41(3):267-71.
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  237. Tchkonia T, Tchoukalova YD, Giorgadze N, Pirtskhalava T, Karagiannides I, Forse RA, Koo A, Stevenson M, Chinnappan D, Cartwright A, Jensen MD, Kirkland JL. Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E267-77. Epub 2004 Sep 21.
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  238. Han J, Hamilton JA, Kirkland JL, Corkey BE, Guo W. Medium-chain oil reduces fat mass and down-regulates expression of adipogenic genes in rats. Obes Res. 2003 Jun; 11(6):734-44.
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  239. Tchkonia T, Corkey BE, Kirkland JL. Current views of the fat cell as an endocrine cell: lipotoxicity. Endocrine Updates. 2003; 26:105-18.
  240. Kirkland JL, Tchkonia T, Giorgadze N, Pirtskhalava T. Adipose tissue as an endocrine organ: regional differences in adipocyte endocrine function. Progress in Obesity Research. 2003; 9:87-95.
  241. Kirkland JL. The biology of senescence: potential for prevention of disease. Clin Geriatr Med. 2002 Aug; 18(3):383-405.
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  242. Naglie G, Tansey C, Kirkland JL, Ogilvie-Harris DJ, Detsky AS, Etchells E, Tomlinson G, O'Rourke K, Goldlist B. Interdisciplinary inpatient care for elderly people with hip fracture: a randomized controlled trial. CMAJ 9. 2002 Jul 9; 167: (1)25-32.
  243. Kirkland JL, Tchkonia T, Pirtskhalava T, Han J, Karagiannides I. Adipogenesis and aging: does aging make fat go MAD? Exp Gerontol. 2002 Jun; 37(6):757-67.
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  244. Tchkonia T, Giorgadze N, Pirtskhalava T, Tchoukalova Y, Karagiannides I, Forse RA, DePonte M, Stevenson M, Guo W, Han J, Waloga G, Lash TL, Jensen MD, Kirkland JL. Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes. Am J Physiol Regul Integr Comp Physiol. 2002 May; 282(5):R1286-96.
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  245. Han J, Farmer SR, Kirkland JL, Corkey BE, Yoon R, Pirtskhalava T, Ido Y, Guo W. Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes. J Nutr. 2002 May; 132(5):904-10.
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  246. Karagiannides I, Tchkonia T, Dobson DE, Steppan CM, Cummins P, Chan G, Salvatori K, Hadzopoulou-Cladaras M, Kirkland JL. Altered expression of C/EBP family members results in decreased adipogenesis with aging. Am J Physiol Regul Integr Comp Physiol. 2001 Jun; 280(6):R1772-80.
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  247. Caserta F, Tchkonia T, Civelek VN, Prentki M, Brown NF, McGarry JD, Forse RA, Corkey BE, Hamilton JA, Kirkland JL. Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes. Am J Physiol Endocrinol Metab. 2001 Feb; 280(2):E238-47.
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  248. Ewart CV, Fearon NA, Lund M, Martin B, Kirkland JL, Ritchie CS, Quatromoni P, Silliman RA, Millen BE. Subject recruitment, retention, and protocol feasibility in a prospective study of nutritional risk among urban, frail homebound elders. J Nutr Elder. 2001; 21:1-21.
  249. Tchkonia T, Karagiannides I, Forse RA, Kirkland JL. Different fat depots are distinct mini-organs. Curr Opin Endocrinol Diabetes Obes. 2001; 8:227-34.
  250. Millen BE, Silliman RA, Cantey-Kiser J, Copenhafer DL, Ewart CV, Ritchie CS, Quatromoni PA, Kirkland JL, Chipkin SR, Fearon NA, Lund ME, Garcia PI, Barry PP. Nutritional risk in an urban homebound older population. The nutrition and healthy aging project. J Nutr Health Aging. 2001; 5(4):269-77.
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  251. Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA. Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate. Biochem J. 2000 Jul 15; 349(Pt 2):463-71.
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  252. Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA. Incorporation of [1-13C]oleate into cellular triglycerides in differentiating 3T3L1 cells. Lipids. 1999 Aug; 34(8):825-31.
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  253. Guo W, Kirkland JL, Corkey B, Hamilton JA. A 13C nuclear magnetic resonance study of free fatty acid incorporation in acylated lipids in differentiating preadipocytes. Lipids. 1998 May; 33(5):449-54.
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  254. Kirkland JL, Hollenberg CH. Inhibitors of preadipocyte replication: opportunities for the treatment of obesity. Prog Mol Subcell Biol. 1998; 20:177-95.
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  255. Brown NF, Hill JK, Esser V, Kirkland JL, Corkey BE, Foster DW, McGarry JD. Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes. Biochem J. 1997 Oct 1; 327((Pt 1)):225-31.
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  256. Kirkland JL, Dobson DE. Preadipocyte function and aging: links between age-related changes in cell dynamics and altered fat tissue function. J Am Geriatr Soc. 1997 Aug; 45(8):959-67.
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  257. Straus SE, Kirkland JL, Verwoerd R, Hamilton L, Gottfried M, Naglie G. Discharges home following intensive inpatient geriatric rehabilitation. Can J Rehabil. 1997; 11:81-7.
  258. Teichert-Kuliszewska K, Hamilton BS, Roncari DA, Kirkland JL, Gillon WS, Deitel M, Hollenberg CH. Increasing vimentin expression associated with differentiation of human and rat preadipocytes. Int J Obes Relat Metab Disord. 1996 Mar; 20 Suppl 3:S108-13.
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  259. Kirkland JL, Hollenberg CH, Gillon WS. Effects of fat depot site on differentiation-dependent gene expression in rat preadipocytes. Int J Obes Relat Metab Disord. 1996 Mar; 20 Suppl 3:S102-7.
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  260. McDermott GF, Ingram A, Scholey J, Kirkland JL, Whiteside CI. Glomerular dysfunction in the aging Fischer 344 rat is associated with excessive growth and normal mesangial cell function. J Gerontol A Biol Sci Med Sci. 1996 Mar; 51(2):M80-5.
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  261. Brymer CD, Kohm CA, Naglie G, Shekter-Wolfson L, Zorzitto ML, O'Rourke K, Kirkland JL. Do geriatric programs decrease long-term use of acute care beds? J Am Geriatr Soc. 1995 Aug; 43(8):885-9.
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  262. Naglie G, Goldlist B, Kirkland J, Gordon M, Klapecki K, Young J, Clark P. Cluster deaths in long-term care institutions: an investigation of excess deaths in two Ontario institutions. J Public Health. 1995 Mar-Apr; 86(2):120-3.
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  263. Kirkland JL, Hollenberg CH, Kindler S, Roncari DA. Long-chain fatty acids decrease lipoprotein lipase activity of cultured rat adipocyte precursors. Metabolis. 1994 Feb; 43(2):144-51.
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  264. Kirkland JL, Hollenberg CH, Kindler S, Gillon WS. Effects of age and anatomic site on preadipocyte number in rat fat depots. J Gerontol. 1994 Jan; 49(1):B31-5.
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  265. Kirkland JL, Hollenberg CH, Gillon WS. Ageing, differentiation, and gene expression in rat epididymal preadipocytes. Biochem Cell Biol. 1993 Nov-Dec; 71(11-12):556-61.
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  266. Kirkland JL, Hollenberg CH, Gillon WS. Effects of aging on ribosomal protein L7 messenger RNA levels in cultured rat preadipocytes. Exp Gerontol. 1993 Nov-Dec; 28(6):557-63.
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  267. Kirkland JL, Hollenberg CH, Gillon WS. Two preadipocyte subtypes cloned from human omental fat. Obes Res. 1993 Mar; 1(2):87-91.
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  268. Kirkland JL, Hollenberg CH, Gillon W, Kindler S. Effect of hypophysectomy on rat preadipocyte replication and differentiation. Endocrinology. 1992 Dec; 131(6):2769-73.
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  269. Kirkland JL. The biochemistry of mammalian senescence. Clin Biochem. 1992 Apr; 25(2):61-75.
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  270. Kirkland JL, Hollenberg CH, Gillon WS. Age, anatomic site, and the replication and differentiation of adipocyte precursors. Am J Physiol. 1990 Feb; 258(2 Pt 1):C206-10.
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  271. Li ZH, Lu ZD, Kirkland JL, Gregerman RI. Preadipocyte stimulating factor in rat serum: evidence for a discrete 63 kDa protein that promotes cell differentiation of rat preadipocytes in primary cultures. J Cell Physiol. 1989 Dec; 141(3):543-57.
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  272. Wang H, Kirkland JL, Hollenberg CH. Varying capacities for replication of rat adipocyte precursor clones and adipose tissue growth. J Clin Invest. 1989 May; 83(5):1741-6.
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  273. Kirkland JL. Evolution and ageing. Genome. 1989; 31(1):398-405.
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  274. Lu ZD, Pineyro MA, Kirkland JL, Li ZH, Gregerman RI. Prostaglandin-sensitive adenylyl cyclase of cultured preadipocytes and mature adipocytes of the rat: probable role of Gi in determination of stimulatory or inhibitory action. J Cell Physiol. 1988 Jul; 136(1):1-12.
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  275. Kirkland JL, Pineyro MA, Lu ZD, Gregerman RI. Hormone-sensitive adenylyl cyclase in preadipocytes cultured from adipose tissue: comparison with 3T3-L1 cells and adipocytes. J Cell Physiol. 1987 Dec; 133(3):449-60.
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  276. Kirkland JL. The insurability of elderly patients. Trans Assoc Life Insur Med Dir Am. 1987; 70:135-45.
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  277. Schneyer CR, Pineyro MA, Kirkland JL, Gregerman RI. Stimulation of human fat cell adenylate cyclase by GDP and guanosine 5'-O-(2-thiodiphosphate). J Biol Chem. 1984 Jun 10; 259(11):7038-44.
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  278. Kirkland J, Lye M, Goddard C, Vargas E, Davies I. Plasma arginine vasopressin in dehydrated elderly patients. Clin Endocrinol (Oxf). 1984 Apr; 20: (4)451-6.
  279. Kirkland JL, Dax EM. Adipocyte hormone responsiveness and aging in the rat: problems in the interpretation of aging research. J Am Geriatr Soc. 1984 Mar; 32(3):219-28.
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  280. Hickey DS, Kirkland JL, Lucas SB, Lye M. Analysis of circadian rhythms by fitting a least squares sine curve. Comput Biol Med. 1984; 14(2):217-23.
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  281. Kirkland JL, Lye M, Levy DW, Banerjee AK. Patterns of urine flow and electrolyte excretion in healthy elderly people. Br Med J (Clin Res Ed). 1983 Dec 3; 287: (6406)1665-7.
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  282. Kirkland JL, Pearson DJ, Goddard C, Davies I. Polyuria and inappropriate secretion of arginine vasopressin in hypothalamic sarcoidosis. J Clin Endocrinol Metab. 1983 Feb; 56(2):269-72.
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  283. Kirkland JL, Lye M, Faragher EB, dos Santos AG. A longitudinal study of the prognostic significance of ventricular ectopic beats in the elderly. Gerontology. 1983; 29(3):199-201.
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  284. Brocklehurst JC, Kirkland JL, Martin J, Ashford J. Constipation in long-stay elderly patients: its treatment and prevention by lactulose, poloxalkol-dihydroxyanthroquinolone and phosphate enemas. Gerontology. 1983; 29(3):181-4.
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  285. Kirkland JL, Vargas E, Lye M. Indican excretion in the elderly. Postgrad Med J. 1983; 59:43-5.
  286. Van Loon GR, Mascardo R, Shum A, Kim C, Datta H, Green S, Kirkland J, Sole MJ, Kamble A. Monoaminergjc regulation of the neuroendocrine transducer which controls ACTH secretion. Neuropsychopharmacology. 1978; 2:939-947.