Brian P. O'Neill, M.D.

  1. Neurologist

Specialty Groups


  1. Rochester, Minnesota



Brian P. O'Neill, M.D., is a neurologist who specializes in brain cancer and neurological complications of systemic cancers. He has over 30 years' experience in the field and has had administrative and research leadership roles nationally.

Dr. O'Neill is currently the co-leader of the Mayo Clinic Cancer Center (MCCC) Translational Research Program in Neuro-Oncology ("the program") and overall principal investigator and program director of the National Cancer Institute (NCI)-funded Specialized Program of Research Excellence (SPORE) in Brain Cancer.

Mayo Clinic's clinical activities are enterprisewide with expertise and relevant clinical research at all three Mayo campuses. The clinical activities of the program are managed by specialists in neurology, neurosurgery and oncology (medical, radiation and pediatric oncology), and are supported by experts in neuropathology and neuroradiology.

  • Primary central nervous system lymphoma
  • Neurological complications of systemic lymphoma
  1. 1976
    Research Associate - Experimental NeuropathologyUniversity of Virginia School of Medicine
  2. 1975
    Resident - NeurologyUniversity of Virginia Hospitals
  3. 1974
    Fellow - NeuropathologyNational Hospital for Nervous Disorders
  4. 1972
    Resident - Internal MedicineEmory University Hospital
  5. 1970
    MDState University of New York - College of Medicine, Syracuse

Awards and honors

  1. 2008
    Best Doctors in AmericaAwarding Organization
  2. 2000
    The International Directory of Distinguished LeadershipAwarding Organization
  3. 1998
    Outstanding Contributions to Education in Neurologic Oncology AwardDepartments of Neurology and Neurosurgery, Mayo Clinic
  4. 1996
    Who's Who in Science and EngineeringAwarding Organization
    "Landmark" article citation for publication B5American Academy of Neurology
    Who's Who in the World (17th Edition)Awarding Organization

Professional memberships

  1. 2002 - present
    MemberInstitutional PI for CNS studies, Mayo Clinic Cancer Center - Rochester, Mayo Clinic Cancer Center
  2. 2000 - 2004
    MemberBrain/CNS Committee, American College of Surgeons Oncology Group
  3. 2000 - 2004
    MemberNeuroscience Scientific Committee, Children's Oncology Group
  4. 2000 - present
    Executive Committee MemberNeuro-Oncology Section, American Academy of Neurology
  5. 1999 - present
    MemberExecutive Committee, Mayo Clinic Cancer Center - Rochester, Mayo Clinic Cancer Center
  6. 1999 - present
    MemberAmerican Association for Cancer Research
  7. 1998 - 2002
    ChairExternal Advisory Board, NABTT Brain Tumor Consortium, National Cancer Institute
  8. 1998
    CoordinatorAdvisory Group for Primary CNS Lymphoma, National Cancer Institute, National Institutes of Health
  9. 1998 - present
    Full MemberMayo Clinic Cancer Center - Rochester, Mayo Clinic Cancer Center
  10. 1996 - 2003
    DirectorLinse-Bock Program, Mayo Clinic Cancer Center - Rochester, Mayo Clinic Cancer Center
  11. 1994 - 1996
    MemberAANS/AAN/Astro Low-grade Glioma Practice Parameters Subcommittee, American Academy of Neurology
  12. 1993 - 1994
    PresidentCentral Society for Neurological Research
  13. 1992
    MemberCNS Tumor Strategy Meeting, National Cancer Institute, National Institutes of Health
  14. 1988 - 1990
    MemberMembership Advisory Committee, American Neurological Association
  15. 1986 - present
    MemberAmerican Society of Clinical Oncology
  16. 1984 - present
    MemberAmerican Neurological Association
  17. 1983 - present
    FellowAmerican Academy of Neurology
    DirectorTranslational Research Program in Neuro-Oncology, Translational Research, Mayo Clinic Cancer Center - Rochester
    MemberAmerican Academy of Neurology