Traveling by Car, Bus or Train

Traveling by car

Rochester, Minn., is located 10 miles north of Interstate 90 and about 50 miles east of Interstate 35. U.S. Highway 52, a four-lane highway, connects Rochester to Minneapolis and St. Paul, Minn., which are located approximately 90 miles northwest of Rochester. U.S. highways 14 and 63 also intersect with Rochester.

See driving directions to Mayo Clinic in Rochester, Minn.

Traveling by bus

Jefferson Lines serves Rochester, Minn., with connecting service from locations throughout the United States. Call 800-451-5333 (toll-free) for tickets and more information.

Traveling by train

Amtrak offers daily passenger service between Chicago and Minneapolis/St. Paul. This service includes a scheduled stop in Winona, Minn., which is located 43 miles east of Rochester. Call Amtrak at 800-872-7245 (toll-free) for transportation information.

Taxi, limousine, bus and shuttle service from Winona to Rochester are available.

The Winona Amtrak station is open seven days a week from 8:45 a.m. to 11:45 a.m. and 5:45 p.m. to 8:45 p.m. Call the Winona Amtrak station at 507-452-8612 for more information.

Mayo Clinic Concierge Services/ can assist you with questions related to lodging, transportation, local businesses and attractions.

For more details about traveling to Rochester, see the Rochester Convention & Visitors Bureau.