Who first used the name "Mayo Clinic"? Surprisingly, it did not originate within the clinic, but rather came from the medical profession. Initially, the Mayo brothers included each partner's name in their firm's title.

Physicians who came to Rochester to see the Mayos operate frequently referred to their destination as "the Mayo Brothers' Clinic" or "Mayos' Clinic." The railroads and patients quickly made these shorter references popular. However, the partnership name remained until the 1914 Building was erected, and establishment of Mayo's educational program and foundation made the name "Mayo Clinic" correct.