An enlarged spleen is usually a sign of an underlying problem. Treatment varies, depending on what's causing the enlargement.
In myelofibrosis, healthy bone marrow is replaced with scar tissue, leading to severe anemia and fatigue.
Feb. 24, 2016
- AskMayoExpert. Spleen disorders and splenectomy. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Barbara Woodward Lips Patient Education Center. Preparing for surgery to remove your child's spleen. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2012.
- Barbara Woodward Lips Patient Education Center. Splenectomy: Spleen removal. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Taner T, et al. Splenectomy for massive splenomegaly: Long-term results and risks for mortality. Annals of Surgery. 2013;258:1034.
- Yeo CJ, ed. Splenectomy for conditions other than trauma. In: Shackelford's Surgery of the Alimentary Tract. 7th ed. Philadelphia, Pa.: Elsevier; 2013.
- Rubin LG, et al. Care of the asplenic patient. New England Journal of Medicine. 2014;371:349.
- Edgren G, et al. Splenectomy and the risk of sepsis: A population-based cohort study. Annals of Surgery. 2014;260:1081.