An enlarged spleen is usually a sign of an underlying problem. Treatment varies, depending on what's causing the enlargement.
Idiopathic thrombocytopenic purpura is a blood-clotting disorder that can lead to easy bruising and bleeding. Treatment depends on the severity of symptoms.
In myelofibrosis, healthy bone marrow is replaced with scar tissue, leading to severe anemia and fatigue.
A ruptured spleen is a medical emergency. Immediate surgery is needed to prevent life-threatening bleeding.
July 20, 2012
- Splenomegaly. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/hematology_and_oncology/spleen_disorders/splenomegaly.html. Accessed May 15, 2012.
- Landaw SA, et al. Approach to the adult patient with splenomegaly and other splenic disorders. http://www.uptodate.com/index. Accessed May 15, 2012.
- Hoffman R, et al. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2009. http://www.mdconsult.com/books/about.do?about=true&eid=4-u1.0-B978-0-443-06715-0..X5001-8--TOP&isbn=978-0-443-06715-0&uniqId=230100505-56. Accessed May 15, 2012.
- Maurus CF. Laparoscopic versus open splenectomy for nontraumatic diseases. World Journal of Surgery. 2008;32:2444.
- Townsend CM Jr, et al. Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice. 19th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.mdconsult.com/das/book/body/208746819-6/0/1565/0.html. Accessed May 15, 2012.
- Patient information for laparoscopic spleen removal (splenectomy) from SAGES. Society of American Gastrointestinal and Endoscopic Surgeons. http://www.sages.org/publications/publication.php?id=PI12. Accessed May 15, 2012.
- Cadili A, et al. Complications of splenectomy. The American Journal of Medicine. 2008;121:371.
- Mesa RA (expert opinion). Mayo Clinic, Rochester, Minn. June 4, 2012.