Nephrectomy (nuh-FREK-tuh-me) is a surgical procedure to remove all or part of a kidney:
- Complete nephrectomy. During a complete (radical) nephrectomy, the surgeon removes the entire kidney.
- Partial nephrectomy. In a partial nephrectomy, the surgeon removes diseased tissue from a kidney and leaves healthy tissue in place.
A nephrectomy may be performed to treat kidney cancer or to remove a seriously damaged or diseased kidney. In a donor nephrectomy, the surgeon removes a healthy kidney for transplant into a person who needs a functioning kidney.
The surgeon may perform a nephrectomy procedure through a single large incision in the abdomen or side (open nephrectomy) or through a series of small incisions in the abdomen (laparoscopic nephrectomy).
A surgeon performs a nephrectomy either to remove a diseased kidney or to harvest a healthy kidney intended for an organ transplant.
Most people have two kidneys — fist-sized organs located near the back of the upper abdomen. Your kidneys:
- Filter wastes and excess fluid and electrolytes from your blood
- Produce urine
- Maintain proper levels of minerals in your bloodstream
- Produce hormones that help regulate your blood pressure and that influence the number of circulating red blood cells
Often, a surgeon performs nephrectomy to remove a cancerous tumor or abnormal tissue growth in a kidney. The most common kidney cancer in adults, renal cell carcinoma, begins in the cells that line the small tubes within your kidneys. Children are more likely to develop a type of kidney cancer called Wilms' tumor, probably caused by the poor development of kidney cells.
The decision about how much kidney tissue to remove depends on:
- Whether a tumor is confined to the kidney
- Whether there is more than one tumor
- How much of the kidney is affected
- Whether the cancer affects nearby tissue
- How well the other kidney functions
The surgeon makes a decision based on the results of imaging tests, which may include:
- Ultrasound, an image of soft tissues produced with the use of sound waves
- Computerized tomography (CT), a specialized X-ray technology that produces images of thin cross-sectional views of soft tissues
- Magnetic resonance imaging (MRI), which uses a magnetic field and radio waves to produce cross-sectional views or 3-D images
Treatment for other conditions
A partial or radical nephrectomy may be needed to remove severely damaged, scarred or nonfunctioning kidney tissue due to traumatic injury or other diseases.
A healthy person with good kidney function and a low risk of certain disorders, such as high blood pressure or diabetes, is a good candidate for donating a kidney to someone who needs a transplant. A transplant recipient who receives a kidney from a living donor has a better chance that the transplanted kidney will survive than does a person who receives a kidney from a deceased donor.
Long-term complications from a nephrectomy relate to potential problems of living with less than two complete, fully functioning kidneys. Although overall kidney function decreases following a nephrectomy, the remaining kidney tissue usually works well enough for a healthy life.
Problems that may occur with long-term decreased kidney function include:
- High blood pressure (hypertension)
- Chronic kidney disease
Before surgery, you'll talk with your surgeon about what options are available for you. Questions you might ask include:
- Will I need a partial or complete nephrectomy?
- Am I a candidate for a minimally invasive (laparoscopic) procedure?
- What are the chances that I'll need a complete nephrectomy even if a partial nephrectomy is planned?
- If the surgery is for treating cancer, what other related procedures or treatments might I need?
Planning your hospital stay
You may need to stay in the hospital from one to five days, depending on the type of procedure. Ask your surgeon and health care team about your probable recovery time.
Preparing for the surgery
You'll receive instructions about what to do the day before and the day of your surgery. Make note of any questions you might have, such as:
- When do I need to begin fasting?
- Can I take my prescription medications?
- If so, how soon before the surgery can I take a dose?
- What nonprescription medications should I avoid?
- When do I need to arrive at the hospital?
Planning for a donor nephrectomy
If you're planning to donate a kidney for a transplant, you'll have certain tests and exams done to make sure you're a suitable candidate.
Criteria for being an ideal kidney donor include:
- Age 18 years or older
- Compatible blood type with kidney transplant recipient
- General good health
- Two well-functioning kidneys
- No history of high blood pressure, kidney disease, diabetes, certain cancers or major risk factors for heart and blood vessel (cardiovascular) disease
- Stable mental health
A nephrectomy procedure is performed during general anesthesia. You'll receive a medication (anesthetic) before surgery so that you won't be awake or feel pain during surgery. You'll also have a urinary catheter — a small tube that drains urine from your bladder — placed before surgery.
During the procedure
The nephrectomy procedure varies, depending on how the surgery is performed and how much of the kidney is removed. Variations include:
- Open surgery. In an open nephrectomy, the surgeon makes a cut (incision) along your side or on your abdomen — usually between the lower ribs on the side of the affected kidney. The surgeon may need to remove a lower rib to gain better access to the kidney.
- Laparoscopic surgery. In this minimally invasive procedure, the surgeon makes a few small incisions in your abdomen to insert wand-like devices equipped with video cameras and small surgical tools. The surgeon makes a somewhat larger opening if your entire kidney needs to be removed.
- Robot-assisted laparoscopic surgery. In a variation of laparoscopic surgery, the surgeon may use a robotic system to perform the procedure. Robotic tools require very small incisions, provide better imaging of the procedure and enable precise removal of diseased tissue.
- Radical nephrectomy. In a radical nephrectomy, the surgeon removes the whole kidney, the fatty tissues surrounding the kidney and a portion of the tube connecting the kidney to the bladder (ureter). The surgeon may remove the adrenal gland that sits atop the kidney if a tumor is close to or involves the adrenal gland.
- Partial nephrectomy. In a partial nephrectomy — also called kidney-sparing surgery — the surgeon removes a cancerous tumor or diseased tissue and leaves in as much healthy kidney tissue as possible.
The smaller incisions in robotic and laparoscopic surgery usually mean less pain after surgery and a faster return to normal activities.
After the procedure
Recovery time after the procedure and the length of your hospital stay depend on your overall health and the type of nephrectomy performed. The urinary catheter remains in place for a short time during your recovery.
Expect to receive instructions before leaving the hospital about restrictions to your diet and activities. You may be encouraged to begin light, everyday activities as soon as you feel able, but you'll need to avoid strenuous activity or heavy lifting for several weeks.
Questions that you may want to discuss with your surgeon, cancer specialist (oncologist) or other members of your health care team following your nephrectomy include:
- Were you able to remove all of the cancerous or diseased tissue?
- How much of the kidney was removed?
- Will I need to have any treatments if cancer has spread to other organs?
- How often will my kidney function need to be monitored?
Monitoring kidney function
Most people can function well with only one kidney or with one whole kidney and part of the second. You'll likely have checkups to monitor the following factors related to kidney function.
- Blood pressure. You'll need careful monitoring of your blood pressure because decreased kidney function can increase blood pressure — and high blood pressure can, in turn, damage your kidney.
- Protein urine levels. High protein urine levels (proteinuria) may indicate kidney damage and poor kidney function.
- Waste filtration. Glomerular filtration rate is a measure of how efficiently your kidney filters waste. The test is usually performed with a sample of blood. A reduced filtration rate indicates decreased kidney function.
Taking care of your remaining kidney
After a nephrectomy or partial nephrectomy, you may have overall normal kidney function. To preserve normal kidney function, your doctor may recommend that you eat a healthy diet, engage in daily physical activity and attend regular checkups to monitor your kidney health.
If you develop kidney disease in your remaining kidney after nephrectomy or partial nephrectomy, your doctor may recommend changes to your diet, such as limiting salt or protein.
- Extensive expertise and experience. Highly skilled Mayo Clinic urologic surgeons have performed thousands of nephrectomies over the years and more than 2,500 partial nephrectomies since 2005. Mayo Clinic was one of the first medical centers to begin performing this procedure more than 30 years ago.
- Minimally invasive options. At Mayo Clinic, partial nephrectomy is the preferred treatment for small, single tumors located in only one kidney. Mayo experts use advanced surgical techniques to offer less invasive laparoscopic and robot-assisted options for partial nephrectomy. The smaller incisions in robotic and laparoscopic surgery usually mean you'll have less pain after surgery and a faster return to your normal activities.
- Research leader. Mayo Clinic has long been at the forefront of research on kidney-sparing surgery. Mayo Clinic tracks the results of Mayo Clinic patients treated for kidney cancer, focusing on how to improve outcomes. Research at Mayo Clinic and elsewhere shows overall higher survival rates for people who had only part of a kidney removed (partial nephrectomy) compared with people who had a whole kidney removed (radical nephrectomy).
Mayo Clinic in Rochester, Minn., ranks No. 1 for kidney disorders in the U.S. News & World Report Best Hospitals rankings. Mayo Clinic in Scottsdale, Ariz., ranks among the Best Hospitals for kidney disorders by U.S. News & World Report. Mayo Clinic in Jacksonville, Fla., is ranked high performing for kidney disorders by U.S. News & World Report.
Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people. In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.
At Mayo Clinic's campus in Arizona, specialists in urology perform nephrectomies and partial nephrectomies in adults.
For appointments or more information, call the Central Appointment Office at 800-446-2279 (toll-free) 8 a.m. to 5 p.m. Mountain Standard Time, Monday through Friday or complete an online appointment request form.
- U.S. Patients
- International Patients
At Mayo Clinic's campus in Florida, specialists in urology perform nephrectomies and partial nephrectomies in adults.
For appointments or more information, call the Central Appointment Office at 904-953-0853 8 a.m. to 5 p.m. Eastern time, Monday through Friday or complete an online appointment request form.
- U.S. Patients
- International Patients
At Mayo Clinic's campus in Minnesota, specialists in urology perform nephrectomies and partial nephrectomies in adults and children.
For appointments or more information, call the Central Appointment Office at 507-538-3270 7 a.m. to 6 p.m. Central time, Monday through Friday or complete an online appointment request form.
- U.S. Patients
- International Patients
See information on patient services at the three Mayo Clinic locations, including transportation options and lodging.
The Department of Urology at Mayo Clinic has long been at the forefront of research on partial nephrectomy, also called kidney-sparing surgery. Mayo Clinic studies suggest that:
- People with kidney cancers smaller than 1.5 inches (about 4 centimeters) have a significantly higher 10-year survival rate compared with those who had their entire kidney removed.
- In more-advanced stages of local cancers, outcomes and survival rates appeared similar for people whether they had a partial nephrectomy or a radical nephrectomy.
- Restriction of the blood supply (ischemia) has little effect on long-term kidney function after partial nephrectomy.
- Experienced surgeons can achieve good outcomes with minimally invasive partial and radical nephrectomies, reducing the need for open surgery.
Survival rates also appear to relate to surgical training, experience and expertise.
See a list of publications by Mayo doctors on nephrectomy and partial nephrectomy on PubMed, a service of the National Library of Medicine.
May 16, 2015
- Nephrectomy. National Kidney Foundation. https://www.kidney.org/atoz/content/nephrectomy. Accessed April 15, 2015.
- Renal cell carcinoma. The Merck Manual Professional Edition. http://www.merckmanuals.com/professional/genitourinary-disorders/genitourinary-cancer/renal-cell-carcinoma. Accessed April 20, 2015.
- Wilms' tumor. The Merck Manual Professional Edition. http://www.merckmanuals.com/professional/pediatrics/pediatric-cancers/wilms-tumor. Accessed April 20, 2015.
- Wein AJ, et al., eds. Contemporary open surgery of the kidney. In: Campbell-Walsh Urology. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed April 16, 2015.
- Wein AJ, et al., eds. Laparoscopic surgery of the kidney. In: Campbell-Walsh Urology. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed April 16, 2015.
- Solitary kidney. National Kidney and Urologic Diseases Information Clearinghouse. http://kidney.niddk.nih.gov/kudiseases/pubs/solitarykidney. Accessed April 15, 2015.
- Richie JP. Definitive surgical management of renal cell carcinoma. http://www.uptodate.com/home. Accessed April 22, 2015.
- Ramos E, et al. Evaluation of the living kidney donor and risk of donor nephrectomy. http://www.uptodate.com/home. Accessed April 22, 2015.
- AskMayoExpert. Donor nephrectomy living kidney donor. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- AskMayoExpert. Partial nephrectomy. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Shapiro R, et al. Benefits and complications of laparoscopic donor nephrectomy. http://www.uptodate.com/home. Accessed April 22, 2015.
- Cook AJ. Decision Support System. Mayo Clinic, Rochester, Minn. Jan. 13, 2015.
- Leach GE, et al. Partial nephrectomy: Mayo Clinic experience 1957-1977. Urology. 1980;15:219.
- Thompson RH, et al. Radical nephrectomy for pT1a renal masses may be associated with decreased overall survival compared with partial nephrectomy. The Journal of Urology. 2008;179:468.
- Breau RH, et al. Outcome of stage T2 or greater renal cell cancer treated with partial nephrectomy. The Journal of Urology. 2010;183:903.
- Thompson RH, et al. Partial versus radical nephrectomy for 4 to 7 cm renal cortical tumors. The Journal of Urology. 2009;182:2601.
- Tan HJ, et al. Long-term survival following partial vs. radical nephrectomy among older patients with early-stage kidney cancer. Journal of the American Medical Association. 2012;307:1629.
- Castle EP (expert opinion). Mayo Clinic, Phoenix, Ariz. May 1, 2015.
- Salevitz DA, et al. The impact of ischemia on long-term renal function after partial nephrectomy in the two kidney model. Journal of Endourology. 2015;29:474.
- Wisenbaugh ES, et al. Massive renal size is not a contraindication to a laparoscopic approach for bilateral native nephrectomies in autosomal dominant polycystic kidney disease (ADPKD). BJU International. 2015;115:796.