Mayo Clinic surgeons perform living-donor transplant surgery for liver transplant and kidney transplant.

Generally, your blood and tissue types need to be compatible with the organ recipient. If you're donating part of a liver, you'll need to have the appropriate size liver for the recipient.

However, if you're a kidney donor and your blood and tissue types aren't compatible with the recipient, then other types of living-donor kidney transplants may be available in some cases. Mayo Clinic transplant programs offer:

  • Blood type (ABO) incompatible kidney transplants. In an ABO incompatible kidney transplant, your blood type isn't compatible with the recipient's blood type.
  • Paired donation. In paired kidney donation, donors and their recipients may not be compatible, or recipients may benefit from a kidney that is a different size or age from the original donor. Or, donors and their recipients may be compatible, but they wish to participate in paired kidney donation.

    If another donor and recipient pair is also incompatible, exchanging donors may allow both recipients to have transplants with kidneys that match their needs.

  • Positive crossmatch kidney transplants. In a positive crossmatch kidney transplant, you're not compatible with the recipient because the recipient has high levels of antibodies in his or her blood that react against your cells.

    Mayo Clinic researchers have developed protocols that may make this procedure possible under certain circumstances.

  • Nondirected (anonymous) kidney donation. In a nondirected (anonymous) kidney donation, you have no intended recipient, but you're offering the kidney as a gift to be used for the most appropriate recipient, who will be selected by the transplant center.

    You'll be evaluated to determine if you fit the criteria to be an organ donor. You'll also have a mental and social (psychosocial) evaluation to evaluate your motivation for donating an organ and your support system.

    If it's determined you fit the criteria to be an organ donor, your kidney will be given to a recipient who may best benefit from a kidney.

Nov. 12, 2014