Facial fillers are substances that temporarily soften wrinkles when injected into your skin. How long the effect lasts depends on factors such as the type of wrinkle and filler used.

  • Experience. Each year Mayo Clinic cosmetic surgery specialists perform almost 3,000 procedures to the skin, including facial filler procedures for wrinkles.
  • Expertise. At Mayo Clinic, facial fillers are done only by board-certified doctors trained in cosmetic surgery. If the need arises, you have access to all of Mayo's experts, facilities and technology. Mayo Clinic offers a variety of facial filler options and procedures to address the needs of individual patients, all approved by the Food and Drug Administration.
  • Time for you. Your Mayo Clinic specialist will take time to discuss options and answer your questions about facial fillers.
  • Efficient care. At Mayo Clinic, your appointments are coordinated, so you usually can complete your treatment in a few days.

Injection of a facial filler is an outpatient cosmetic surgery procedure that temporarily softens wrinkles. The procedure may be done under local anesthesia and takes up to an hour. You may have mild discomfort, bruising and swelling for up to a week. After the swelling goes down, you may need a touch-up injection for best results.

Hyaluronic acid

Hyaluronic acid is a natural component of the skin's connective tissue. Due to its safety and efficacy, hyaluronic acid has become the most common filler used in aesthetic medicine. Hyaluronic acid injections can soften fine lines and creases and restore fullness to your skin. Several hyaluronic acid products are available. They are designed with different-sized particles for different wrinkle depths. Brands include:

  • Restylane. Injections can soften moderate to severe facial wrinkles. Indications include correction of tear trough creases under the eyes, folds between your nose and mouth, fine lines throughout the face, and lip augmentation. Results usually last an average of six months.
  • Juvederm. Injections can create fuller lips and treat the folds between your nose and mouth, small wrinkles directly above the lips, and wrinkles on the lower and upper face. Results usually last six months to one year.

Calcium hydroxylapatite

Calcium hydroxylapatite (Radiesse) is used to treat deeper wrinkles and skin folds, contour the jaw line, and restore volume in and around the cheeks. Radiesse injections may last up to three years when used to fill wrinkles and up to one year when used for contouring.

Fat grafting

Fat is removed from the lower abdomen or other areas through liposuction and then injected through small incisions into your cheek, temple, lips or forehead. The effects of fat transplantation may be permanent; however, achieving the desired results usually requires more than one session of injections, as well as overfilling the site to compensate for the body's reabsorption of the fat.

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people. In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Specialists in dermatology, plastic surgery and otorhinolaryngology (ENT) at Mayo Clinic's campus in Arizona treat wrinkles with facial fillers.

For appointments or more information, call the Central Appointment Office at 800-446-2279 (toll-free) 8 a.m. to 5 p.m. Mountain Standard Time, Monday through Friday or complete an online appointment request form.

Specialists in plastic surgery at Mayo Clinic's campus in Florida treat wrinkles with facial fillers.

For appointments or more information, call the Central Appointment Office at 904-953-0853 8 a.m. to 5 p.m. Eastern time, Monday through Friday or complete an online appointment request form.

Specialists in dermatology, otorhinolaryngology (ENT) and plastic surgery at Mayo Clinic's campus in Minnesota treat wrinkles with facial fillers.

For appointments or more information, call the Central Appointment Office at 507-538-3270 7 a.m. to 6 p.m. Central time, Monday through Friday or complete an online appointment request form.

June 11, 2015