Treatment at Mayo Clinic

By Mayo Clinic Staff

Injection of a facial filler is an outpatient cosmetic surgery procedure that temporarily softens wrinkles. The procedure may be done under local anesthesia and takes up to an hour. You may have mild discomfort, bruising and swelling for up to a week. After the swelling goes down, you may need a touch-up injection for best results.

Mayo Clinic specialists provide these facial fillers:

Hyaluronic acid

Hyaluronic acid injections can soften fine lines and creases and restore fullness to your skin. Before an injection, your doctor will advise you to avoid aspirin, nonsteroidal anti-inflammatory medications, herbal supplements or high doses of vitamin E. These products may increase bleeding or bruising at the injection site. Several hyaluronic acid products are available, including:

  • Restylane injections can soften moderate to severe facial wrinkles, such as the folds between your nose and mouth. Results usually last at least six months.
  • Juvederm has a higher concentration of hyaluronic acid. Juvederm is used to create fuller lips, and to treat the folds between your nose and mouth, small wrinkles directly above the lips, and wrinkles on the lower and upper face. The results usually last six months to one year.


Radiesse is used to treat deeper wrinkles, contour the jaw line and correct facial imbalance (asymmetry) or facial dips. Radiesse injections may last up to three years when used to fill wrinkles and up to one year when used for contouring.

Fat transplantation

Fat is removed from the lower abdomen or other areas through liposuction and then injected through small incisions into your cheek, temple or forehead. The effects of fat transplantation may be temporary. Achieving the desired results usually requires more than one session of injections, as well as over-filling the site to compensate for the body's reabsorption of the fat. Bruising usually diminishes within three weeks.

As with any operation, injecting facial filler for wrinkles has risks, including:

  • Allergic reaction at the injection site or throughout the body
  • Infection
  • Bleeding
  • Irregularities in the surface, contours and firmness of the skin
May 05, 2014