Aug. 28, 2014
Below are current clinical trials.1 studies in Endoscopic mucosal resection
(open studies only).
Filter this list of studies by location, status and more.
Prospective Evaluation of Budesonide for Prevention of Esophageal Strictures after Endotherapy
Study type: Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase: II What is this?
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
About this study
Surgery has been historically the mainstay treatment for advanced pre-malignant lesions and early esophageal cancers. However, esophagectomy is associated with significant morbidity and mortality. With the advance of therapeutic endoscopy, there has been a growing interest and application of endoscopic resection and mucosal ablative techniques for the treatment of these diseases. Esophageal stricture(ES) formation has become an increasingly recognized complication of extensive endoscopic mucosal ablation and/or resection. The resultant symptomatic stricture development can significantly impair a patient's quality of life. Endoscopic therapy of esophageal strictures with balloon dilation and/or local steroid injection is invasive, costly, and associated with the potential risk of perforation. Recently, oral corticosteroids have been introduced for the prevention of esophageal stricture after endoscopic submucosal dissection.
Budesonide is a synthetic steroid with topical anti-inflammatory properties and high first-pass metabolism; thus, potentially less systemic absorption and side effects.
Hypothesis: Oral budesonide prevents esophageal stricture formation in patients who underwent radical endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) for advanced premalignant esophageal lesions or superficial esophageal cancers.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
- Jacksonville, Florida: 13-009467
Sponsor Protocol Number: 13-009467
- Gunaratnam NT, et al. Overview of endoscopic resection of gastrointestinal tumors. http://www.uptodate.com/home. Accessed July 17, 2014.
- Upper GI endoscopy. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/upperendoscopy/index.aspx. Accessed July 17, 2014.
- Preparing for an upper GI endoscopy. American Gastroenterological Association. http://www.gastro.org/patient-center/procedures/upper-gi-endoscopy. Accessed July 17, 2014.
- Preparing for a colonoscopy. American Gastroenterological Association. http://www.gastro.org/patient-center/procedures/colonoscopy. Accessed July 17, 2014.
- Manath J, et al. Endoscopic mucosal resection: Who and how? Therapeutic Advances in Gastroenterology. 2010;4:275.