Stool DNA test results may include:
Aug. 13, 2014
- Negative result. A test is considered negative if DNA markers common to colon cancer or precancerous polyps and signs of blood are not found in the stool.
- Positive result. A test is considered positive if DNA markers common to colon cancer or precancerous polyps or signs of blood are found in the stool sample. Additional evaluation, such as a colonoscopy to examine the colon, may be recommended to determine the cause.
- Imperiale TF, et al. Multitarget stool DNA testing for colorectal cancer screening. The New England Journal of Medicine. 2014;370:1287.
- Ahlquist DA, et al. Next generation stool DNA test accurately detects colorectal cancer and large adenomas. Gastroenterology. 2012;142:248.
- Heigh RI, et al. Detection of colorectal serrated polyps by stool DNA testing: Comparison with fecal immunochemical testing for occult blood (FIT). PLOS One. 2014;9:e85659. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0085659. Accessed March 18, 2014.
- Ahlquist DA, et al. The stool DNA test is more accurate than the plasma septin 9 test in detecting colorectal neoplasia. Clinical Gastroenterology and Hepatology. 2012;10:272.
- Fecal DNA testing in screening for colorectal cancer in average-risk adults. Rockville, Md.: Agency for Healthcare Research and Quality. http://effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productid=988. Accessed March 18, 2014.
- Fletcher RH. Tests for screening for colorectal cancer: Stool tests, radiologic imaging and endoscopy. http://www.uptodate.com/home. Accessed March 18, 2014.
- Berger BM, et al. Stool DNA screening for colorectal neoplasia: Biological and technical bases for high detection rates. Pathology. 2012;44:80.
- Ahlquist DA, et al. Aberrantly methylated gene marker levels in stool: Effects of demographic, exposure, body mass, and other patient characteristics. Journal of Molecular Biomarkers & Diagnosis. 2012;3:e1. http://omicsonline.org/aberrantly-methylated-gene-marker-levels-in-stool-effects-of-demographic-exposure-body-mass-and-other-patient-characteristics-2155-9929.1000133.php?aid=8381. Accessed June 9, 2014.
- Lidgard GP, et al. Clinical performance of an automated stool DNA assay for detection of colorectal neoplasia. Clinical Gastroenterology and Hepatology. 2013;11:1313.
- Transcript: March 27, 2014. FDA Molecular and Clinical Genetics Panel. U.S. Food and Drug Administration. http://www.fda.gov/AdvisoryCommittees/CommitteesMeetingMaterials/MedicalDevices/MedicalDevicesAdvisoryCommittee/MolecularandClinicalGeneticsPanel/ucm390219.htm. Accessed June 9, 2014.
- FDA approves first non-invasive DNA screening test for colorectal cancer. U.S. Food and Drug Administration. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm409021.htm. Accessed Aug. 11, 2014.