The stool DNA test is a noninvasive laboratory test that identifies DNA changes in the cells of a stool sample. The stool DNA test specifically looks for DNA alterations associated with colon polyps and colon cancer.
The major goal of the stool DNA test is to detect whether DNA changes that indicate colon cancer or precancerous polyps are present in the colon.
One stool DNA test (Cologuard) is approved for use the United States.
Aug. 13, 2014
- Imperiale TF, et al. Multitarget stool DNA testing for colorectal cancer screening. The New England Journal of Medicine. 2014;370:1287.
- Ahlquist DA, et al. Next generation stool DNA test accurately detects colorectal cancer and large adenomas. Gastroenterology. 2012;142:248.
- Heigh RI, et al. Detection of colorectal serrated polyps by stool DNA testing: Comparison with fecal immunochemical testing for occult blood (FIT). PLOS One. 2014;9:e85659. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0085659. Accessed March 18, 2014.
- Ahlquist DA, et al. The stool DNA test is more accurate than the plasma septin 9 test in detecting colorectal neoplasia. Clinical Gastroenterology and Hepatology. 2012;10:272.
- Fecal DNA testing in screening for colorectal cancer in average-risk adults. Rockville, Md.: Agency for Healthcare Research and Quality. http://effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productid=988. Accessed March 18, 2014.
- Fletcher RH. Tests for screening for colorectal cancer: Stool tests, radiologic imaging and endoscopy. http://www.uptodate.com/home. Accessed March 18, 2014.
- Berger BM, et al. Stool DNA screening for colorectal neoplasia: Biological and technical bases for high detection rates. Pathology. 2012;44:80.
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- Lidgard GP, et al. Clinical performance of an automated stool DNA assay for detection of colorectal neoplasia. Clinical Gastroenterology and Hepatology. 2013;11:1313.
- Transcript: March 27, 2014. FDA Molecular and Clinical Genetics Panel. U.S. Food and Drug Administration. http://www.fda.gov/AdvisoryCommittees/CommitteesMeetingMaterials/MedicalDevices/MedicalDevicesAdvisoryCommittee/MolecularandClinicalGeneticsPanel/ucm390219.htm. Accessed June 9, 2014.
- FDA approves first non-invasive DNA screening test for colorectal cancer. U.S. Food and Drug Administration. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm409021.htm. Accessed Aug. 11, 2014.