Chorionic villus sampling carries various risks, including:
- Miscarriage. Overall, chorionic villus sampling carries a 1 in 100 risk of miscarriage. The risk of miscarriage appears to be slightly higher when the tissue sample is taken through the cervix (transcervical) rather than the abdominal wall (transabdominal). The risk of miscarriage also increases if the baby is smaller than normal for his or her gestational age.
- Rh sensitization. Chorionic villus sampling might cause some of the baby's blood cells to enter your bloodstream. If you have Rh negative blood and you haven't developed antibodies to Rh positive blood, you'll be given a drug called Rh immunoglobulin after the test to prevent you from producing antibodies against your baby's blood cells. A blood test can detect if you've begun to produce antibodies.
- Infection. Rarely, chorionic villus sampling might trigger a uterine infection.
Some older studies suggested that chorionic villus sampling might cause defects in a baby's fingers or toes. However, the risk appears to be a concern only if the procedure is done before week nine of pregnancy.
Remember, chorionic villus sampling is typically offered when the test results might have a significant impact on the management of the pregnancy. Ultimately, the decision to have chorionic villus sampling is up to you. Your health care provider or genetic counselor can help you weigh all the factors in the decision.
Oct. 10, 2012
- Ghidini A. Chorionic villus sampling: Risks, complications, and techniques. www.uptodate.com/index. Accessed Aug. 1, 2012.
- Frequently asked questions. Pregnancy FAQ165. Screening for birth defects. American College of Obstetrics and Gynecology. http://www.acog.org/~/media/For%20Patients/faq165.pdf?dmc=1&ts=20120801T1651400794. Accessed Aug. 1, 2012.
- Cunningham FG, et al. Williams Obstetrics. 23rd edition. New York, N.Y.: McGraw-Hill Companies; 2010. http://www.accessmedicine.com/content.aspx?aID=6021591. Accessed Aug. 8, 2012.
- Gabbe SG, et al. Obstetrics: Normal and Problem Pregnancies. 6th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2012:1.
- Frequently asked questions. Pregnancy FAQ027. The Rh factor: How it can affect your pregnancy. American College of Obstetrics and Gynecology. http://www.acog.org/~/media/For%20Patients/faq027.pdf?dmc=1&ts=20120809T1038350240. Accessed Aug. 9, 2012.
- Frequently asked questions. Pregnancy FAQ171. Cystic fibrosis: Prenatal screening and diagnosis. American College of Obstetrics and Gynecology. http://www.acog.org/~/media/For%20Patients/faq171.pdf?dmc=1&ts=20120801T1656571546. Accessed Aug. 1, 2012.
- Moore KL, et al. The Developing Human: Clinically Oriented Embryology. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2013:1.
- Gibbs RS, et al. Danforth's Obstetrics and Gynecology. 10th ed. Philadelphia, Pa.: Wolters Kluwer Health Lippincott Williams & Wilkins; 2008. http://www.danforthsobgyn.com. Accessed Aug. 8, 2012.
- American College of Obstetricians and Gynecologists. Your Pregnancy and Childbirth Month to Month. 5th ed. Washington, D.C.: American College of Obstetricians and Gynecologists; 2010:343.
- Patient information: Chorionic villus sampling. http://www.uptodate.com/index. Accessed Aug. 9, 2012.
- Beckman CRB, et al. Obstetrics and Gynecology. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins; 2010:57.
- Vincent Corbett J, et al. Laboratory Tests and Diagnostic Procedures with Nursing Diagnoses. Upper Saddle River, N.J.: Pearson Education, Inc.; 2013:695.
- Fischbach F, et al. A Manual of Laboratory and Diagnostic Tests. 8th ed. Philadelphia, Pa.: Wolters Kluwer Health Lippincott Williams & Wilkins; 2009:1039.
- Mosby's Manual of Laboratory and Diagnostic Tests. 4th ed. Philadelphia, Pa.: Mosby Elsevier; 2010:1151.
- Harms RW (expert opinion). Mayo Clinic, Rochester, Minn. Aug. 21, 2012.