ResultsBy Mayo Clinic Staff
Results of the CA 125 test are measured in units per milliliter (U/mL). The normal value is less than 35 U/mL.
If your CA 125 level is higher than normal, you may have a benign condition, or the test result could mean that you have ovarian, endometrial, peritoneal or fallopian tube cancer. Your doctor may recommend other tests and procedures to determine your diagnosis.
If you've been diagnosed with ovarian, endometrial, peritoneal or fallopian tube cancer, a decreasing CA 125 level often indicates that the cancer is responding to treatment. A rising CA 125 level may indicate a return or continued growth of the cancer.
A number of normal and noncancerous conditions can cause an elevated CA 125 level, including:
April 14, 2014
- Liver disease
- Pelvic inflammatory disease
- Uterine fibroids
- CA-125. Lab Tests Online. http://labtestsonline.org/understanding/analytes/ca125/tab/glance. Accessed Dec. 10, 2013.
- Understanding CA 125 levels: A guide for ovarian cancer patients. Foundation for Women's Cancer. http://www.foundationforwomenscancer.org/educational-materials/ovarian-cancer. Accessed Dec. 10, 2013.
- Tumor markers: Questions and answers. National Cancer Institute. http://www.cancer.gov/cancertopics/factsheet/detection/tumor-markers. Accessed Dec. 10, 2013.
- Cancer antigen 125 (CA 125), serum. Mayo Medical Laboratories. http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/9289. Accessed Dec. 11, 2013.
- Moyer VA, et al. Screening for ovarian cancer: U.S. Preventive Services Task Force reaffirmation recommendation statement. Annals of Internal Medicine. 2012;157:900.
- Buys SS, et al. Effect of screening on ovarian cancer mortality: The Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening randomized controlled trial. JAMA. 2011;305:2295.
- Reade CJ, et al. Risks and benefits of screening asymptomatic women for ovarian cancer: A systematic review and meta-analysis. Gynecologic Oncology. 2013;130:674-681.
- Genetic/familial high-risk assessment: Breast and ovarian. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Dec. 3, 2013.
- Ovarian cancer including fallopian tube cancer and primary peritoneal cancer. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Dec. 3, 2013.