Diagnosis of systemic mastocytosis can be confirmed by finding
high numbers of mast cells or high levels of the substances they
release in your body, such as tryptase, histamine or
prostaglandins. Tests your doctor may use to confirm systemic
- Bone marrow biopsy. A small amount of your
bone marrow tissue will be analyzed for increased numbers of mast
cells, if this test has not been done already.
- Blood tests. A low number of red blood cells
(anemia) or a high number of a type of white blood cells called
eosinophils may indicate systemic mastocytosis.
- Urine tests. High levels of histamine and
prostaglandins in your urine may also indicate systemic
- Imaging tests. X-rays, ultrasounds and
computerized tomography (CT) scans help to determine the extent
and stage of your condition by providing a picture of your
insides, revealing possible bone or organ involvement.