By Mayo Clinic Staff
High blood protein (hyperproteinemia) is an increase in the concentration of protein in the bloodstream. High blood protein is not a specific disease or condition in itself, but it might indicate you have a disease.
High blood protein rarely causes signs or symptoms on its own. But sometimes it is uncovered while you're having blood tests done as part of an evaluation for some other problem or symptom.
If your doctor discovers high blood protein during an evaluation, he or she may recommend additional tests to determine if there is an underlying problem.
A total protein test can determine whether you have high blood protein. Other more-specific tests can help determine where it's coming from, for instance, the liver or the bone marrow. A serum protein electrophoresis (SPEP) test measures individual blood proteins. It can reveal which specific protein type is causing your high blood protein levels. Your doctor may use a SPEP if he or she suspects you have a bone marrow disease.
Nov. 18, 2014
- Total protein and A/G ratio. American Association for Clinical Chemistry. http://labtestsonline.org/understanding/analytes/tp/tab/glance. Accessed Aug. 25, 2014.
- Amyloidosis and kidney disease. National Kidney and Urologic Diseases Information Clearinghouse. http://kidney.niddk.nih.gov/kudiseases/pubs/amyloidosis/. Accessed Aug. 25, 2014.
- Monoclonal gammopathies of undetermined significance (MGUS). The Merck Manual Home Edition. http://www.merck.com/mmhe/sec14/ch175/ch175b.html. Accessed Aug. 25, 2014.
- Rajkumar SV. Recognition of monoclonal proteins. www.uptodate.com/index. Accessed Aug. 25, 2014.
- Wilkinson JM (expert opinion). Mayo Clinic, Rochester, Minn. Sept. 22, 2014.
- Somers MJ. Clinical assessment and diagnosis of hypovolemia (dehydration) in children. http://www.uptodate.com/home. Accessed Aug. 25, 2014.