Stroke

Clinical Trials

Below is a list of Stroke clinical trials from the clinical trials database at Mayo Clinic.

This list includes only trials about which Mayo researchers choose to publish information. Mayo Clinic may be conducting other trials which are not in this database. Mayo's clinical trials include experimental treatments, often unavailable elsewhere, which frequently lead to improved patient care for people worldwide. Patients should ask their doctor at Mayo about clinical trials appropriate for their situation.

Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST)
This study is being done to compare the results of treating blockages in carotid arteries with either carotid endarterectomy (surgery) OR carotid stent procedure. Carotid endarterectomy is an operation on the carotid artery where the thickened area of the artery is removed through an incision in the neck and is performed under general or local anesthesia. Carotid stenting is a procedure where a metal device called a stent is placed in the narrowed part of the carotid artery to hold it open and is performed under local anesthesia.

The study includes a lead-in phase for credentialing of interventionalists, beyond their initial training and certification requirements.
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Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR III)
This study is a multicenter, international, double-blind, randomized study comparing the use of extraventricular drains (EVD) combined with rt-PA to EVD combined with placebo for the treatment of intraventricular hemorrhagic stroke. The purpose of this study is to examine the long-term effects of resolving blood clots on the functional outcomes of intraventricular hemorrhage patients. We will do this by evaluating if patients treated with rt-PA have a better functional outcome compared to patients treated with placebo.
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Mayo Acute Stroke Trial for Enhancing Recovery
This study involves treating patients who have suffered an acute ischemic stroke with the medication donepezil (Aricept ®). The intention is to see if taking donepezil (FDA-approved for the treatment of Alzheimer's Disease) for the first 90 days following a stroke enhances recovery.
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Minimally Invasive Surgery plus rt-PA for ICH Evacuation (MISTIE)
The purpose of this trial is to determine the safety of using a combination of minimally invasive surgery and clot lysis with rt-PA to remove intracerebral hemorrhage (ICH). The procedure is to use image-based surgery (MRI or CT) to provide catheter access to ICH for the intervention, which is a one-time clot aspiration followed by instillation of rt-PA over 72 hours. We propose to test if this intervention facilitates more rapid and complete recovery of function and decreased mortality from this condition compared to conventional medical management without subjecting the patient to craniotomy. The specific objective of this trial is to test the safety of this intervention and assess its ability to remove blood clot from brain tissue.
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Sibling's with a History of Stroke Sought for Study
The purpose of this research study is to try and identify the genes that increase the risk of developing a stroke.

Genes influencing cholesterol, blood pressure, clotting and other as yet poorly recognized factors may increase the risk of having a stroke. Stroke is a common and often devastating condition. A stroke occurs when the blood supply to the brain is interrupted and brain tissue is deprived of oxygen and nutrients.

Every year about 750,000 Americans experience a stroke; about 160,000 of these people die. Stroke is the leading cause of adult disability and only cardiovascular diseases and cancer cause more deaths annually in the United States.
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The STASH Trial
A blood vessel abnormality called an aneurysm can cause a bleed within the head. The purpose of this trial is to study the potential benefits of giving a standard cholesterol lowering drug (called simvastatin) after a bleed has occurred. This is a licensed medication used regularly in the treatment for other vascular conditions including heart attacks and strokes, but it is not licensed at this stage for the treatment of a bleed in the brain.
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Walking Study for Inpatient Stroke Rehabilitation: A Multi-Center Randomized Clinical Trial of Verbal Encouragement and Measuring Time During a 10-Meter Walk to Improve Walking Speed and Distance
The purpose of this study is to determine whether encouragement to walk faster and feedback on walking speed during inpatient rehabilitation can improve recovery of walking speed in people who have experienced a stroke. The results of this study may help doctors and therapists understand the ways in which walking speed can be improved after stroke.
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