Stroke

Clinical Trials

Below is a list of Stroke clinical trials from the clinical trials database at Mayo Clinic.

Mayo's clinical trials include experimental treatments, often unavailable elsewhere, which frequently lead to improved patient care for people worldwide. Patients should ask their doctor at Mayo about clinical trials appropriate for their situation.

Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis
Activase, the study drug, is a fibrinolytic drug that is indicated for use in acute myocardial infarction, acute ischemic stroke, and acute massive pulmonary embolism in adults. Previous studies have established the ability of rt-PA to lyse venous thrombus in patients with deep vein thrombosis (DVT), and suggest that successful rt-PA mediated thrombolysis can prevent the post-thrombotic syndrome (PTS), a morbid, late complication of
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Albumin in Acute Ischemic Stroke Trial
Human serum albumin, at 2 g/kg, administered over 2 hours by intravenous infusion, will be compared to placebo (isovolumic normal saline) among patients with acute ischemic stroke. All patients will have a baseline stroke severity measured as NIH Stroke scale score > 5.
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Brain and Abdominal Aneurysm Study
Aneurysmal subarachnoid hemorrhage (aSAH) is the most deadly kind of stroke. Each year, 40,000 Americans have SAH. Case-fatality approaches 60% and more than half of those who die do so before reaching the hospital.
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Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR III)
This study is a multicenter, international, double-blind, randomized study comparing the use of extraventricular drains (EVD) combined with rt-PA to EVD combined with placebo for the treatment of intraventricular hemorrhagic stroke. The purpose of this study is to examine the long-term effects of resolving blood clots on the functional outcomes of intraventricular hemorrhage patients.
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Dysport® Adult Lower Limb Spasticity Study
The purpose of this research study is to assess the efficacy of Dysport compared to placebo in improving muscle tone in hemiparetic subjects with lower limb spasticity due to stroke or traumatic brain injury.
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Early Mobilization of Ischemic Stroke Patients Within 24-hours After Intravenous-Tissue Plasminogen Activator (IV-tPA)
Abstract: Introduction Historical precedence exists demonstrating that early intensive care unit (ICU) mobilization of patients reduces risks of complication and lengths of hospital stay, and may improve long-term health status of patients.
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Minimally Invasive Surgery plus rt-PA for ICH Evacuation (MISTIE)
The purpose of this trial is to determine the safety of using a combination of minimally invasive surgery and clot lysis with rt-PA to remove intracerebral hemorrhage (ICH). The procedure is to use image-based surgery (MRI or CT) to provide catheter access to ICH for the intervention, which is a one-time clot aspiration followed by instillation of rt-PA over 72 hours.
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MIS+rtPA for ICH Evacuation
The purpose of this trial is to determine the safety of using a combination of minimally invasive surgery and clot lysis with rt-PA to remove intracerebral hemorrhage (ICH). The procedure is to use image-based surgery (MRI or CT) to provide catheter access to ICH for the intervention, which is a one-time clot aspiration followed by instillation of rt-PA over 72 hours.
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Sibling's with a History of Stroke Sought for Study
The purpose of this research study is to try and identify the genes that increase the risk of developing a stroke. Genes influencing cholesterol, blood pressure, clotting and other as yet poorly recognized factors may increase the risk of having a stroke.
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The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial
Intracerebral haemorrhage (ICH) is one of the most serious subtypes of stroke, affecting over a million people worldwide each year, most of whom live in Asia. About one third of people with ICH die early after onset and the majority of survivors are left with major long-term disability.
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Walking Study for Inpatient Stroke Rehabilitation: A Multi-Center Randomized Clinical Trial of Verbal Encouragement and Measuring Time During a 10-Meter Walk to Improve Walking Speed and Distance
The purpose of this study is to determine whether encouragement to walk faster and feedback on walking speed during inpatient rehabilitation can improve recovery of walking speed in people who have experienced a stroke.
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