Overview By Mayo Clinic Staff Print Vaginal cancer Enlarge image Close Vaginal cancer Vaginal cancer Vaginal cancer begins as a growth of cells in the vagina. The vagina is the muscular tube that connects the uterus with the outer genitals. Vaginal cancer is a growth of cells that starts in the vagina. The cells multiply quickly and can invade and destroy healthy body tissue. The vagina is part of the female reproductive system. It's a muscular tube that connects the uterus with the outer genitals. The vagina is sometimes called the birth canal. Cancer that begins in the vagina is rare. Most cancer that happens in the vagina starts somewhere else and spreads to the vagina. Vaginal cancer that's diagnosed when it's confined to the vagina has the best chance for a cure. When the cancer spreads beyond the vagina, it's much harder to treat. Request an appointment Diagnosis & treatment Oct. 27, 2023 Print Share on: FacebookTwitter Show references Niederhuber JE, et al., eds. Cancers of the cervix, vulva and vagina. In: Abeloff's Clinical Oncology. 6th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Jan. 17, 2023. Hoffman BL, et al. Vaginal cancer. In: Williams Gynecology. 4th ed. McGraw Hill; 2020. https://accessmedicine.mhmedical.com. Accessed Jan. 17, 2023. Karam A, et al. Vaginal cancer. https://www.uptodate.com/contents/search. Accessed Jan. 17, 2023. Vaginal cancer treatment (PDQ) – patient version. National Cancer Institute. https://www.cancer.gov/types/vaginal/patient/vaginal-treatment-pdq. Accessed Jan. 17, 2023. Helm CW. Vaginectomy. https://www.uptodate.com/contents/search. Accessed Jan. 17, 2023. Palliative care. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=3&id=1454. Accessed Jan. 17, 2023. Related Layers of vaginal tissue Vaginal cancer Associated Procedures Brachytherapy Chemotherapy Colposcopy CT scan Cystoscopy MRI Needle biopsy Palliative care Pap smear Pelvic exam Positron emission tomography scan Radiation therapy X-ray Show more associated procedures Products & Services A Book: Mayo Clinic Family Health Book Assortment Women's Health Products from Mayo Clinic Store Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Mayo Clinic in Rochester, Minnesota, has been ranked among the best Gynecology hospitals in the nation for 2024-2025 by U.S. News & World Report. Learn more about this top honor Vaginal cancerSymptoms&causesDiagnosis&treatmentDoctors&departmentsCare atMayoClinic Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Mayo Clinic on Incontinence - Mayo Clinic PressMayo Clinic on IncontinenceThe Essential Diabetes Book - Mayo Clinic PressThe Essential Diabetes BookMayo Clinic on Hearing and Balance - Mayo Clinic PressMayo Clinic on Hearing and BalanceFREE Mayo Clinic Diet Assessment - Mayo Clinic PressFREE Mayo Clinic Diet AssessmentMayo Clinic Health Letter - FREE book - Mayo Clinic PressMayo Clinic Health Letter - FREE book CON-20167630 Patient Care & Health Information Diseases & Conditions Vaginal cancer