Rectal Cancer

Clinical Trials

Below is a list of Rectal Cancer clinical trials from the clinical trials database at Mayo Clinic.

Mayo's clinical trials include experimental treatments, often unavailable elsewhere, which frequently lead to improved patient care for people worldwide. Patients should ask their doctor at Mayo about clinical trials appropriate for their situation.

A Multinational National Institutes of Health-Sponsored Colon Cancer Family Registry
This study is being done to identify individuals from families that have experienced one or more instances of colon cancer, in order to study these families in detail. The current understanding of the environmental and genetic factors that contribute to the development of colon cancer are poorly understood.
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Azacitidine and Entinostat in Treating Patients With Metastatic Colorectal Cancer
OBJECTIVES: Primary objectives - To determine the preliminary efficacy of the combination of azacitidine and entinostat in patients with metastatic colorectal cancer. Secondary objectives - To explore the effects of this regimen on the time to progression in these patients.
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Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy
OBJECTIVES: Primary - To determine whether 2 schedules of calcium gluconate and magnesium sulfate infusions (given before and after chemotherapy or just before chemotherapy) can prevent or ameliorate chronic, cumulative oxaliplatin-induced sensory neurotoxicity in patients with colon or rectal cancer receiving adjuvant FOLFOX chemotherapy comprising leucovorin calcium, fluorouracil, and oxaliplatin.
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Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer
OBJECTIVES: Primary - To compare the progression-free survival (PFS) of elderly patients with metastatic colorectal carcinoma who are randomized to receive fluoropyrimidine-based therapy plus bevacizumab, with or without oxaliplatin. Secondary - In a prospectively planned pooled analysis with a similar trial to be conducted by the Japanese Clinical Oncology Group (JCOG), evaluate and compare the overall survival (OS) of elderly patients with metastatic colorectal carcinoma who
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Laparoscopic-Assisted Resection or Open Resection in Treating Patients With Stage IIA, Stage IIIA, or Stage IIIB Rectal Cancer
OBJECTIVES: Primary - To test the hypothesis that laparoscopic-assisted resection is not inferior to open resection, based on a composite primary endpoint of oncologic factors that are indicative of a safe and feasible surgical resection, in patients with stage IIA, IIIA, or IIIB rectal cancer.
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Sorafenib Tosylate, Bevacizumab, Irinotecan Hydrochloride, Leucovorin Calcium, and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer
OBJECTIVES: Primary - To determine the maximum-tolerated dose of the combination of irinotecan hydrochloride, leucovorin calcium, and fluorouracil (FOLFIRI) plus sorafenib tosylate plus bevacizumab. Secondary - To assess the safety of FOLFIRI plus sorafenib tosylate plus bevacizumab.
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