Primary Sclerosing Cholangitis

Clinical Trials

Below is a list of Primary Sclerosing Cholangitis clinical trials from the clinical trials database at Mayo Clinic.

Mayo's clinical trials include experimental treatments, often unavailable elsewhere, which frequently lead to improved patient care for people worldwide. Patients should ask their doctor at Mayo about clinical trials appropriate for their situation.

A Pilot Study of Vancomycin or Metronidazole in Patients with Primary Sclerosing Cholangitis
The purpose of the study is to determine whether the two doses of each antibiotic, Vancomycin or Metronidazole, are safe and beneficial in the treatment of PSC. The aims of the study are to compare the effectiveness of the two doses of each antibiotic and to compare the antibiotics to each other, and to compare the post-treatment lab values to baseline lab values.
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A Pilot Study of Vancomycin or Metronidazole in Patients With Primary Sclerosing Cholangitis
In this protocol, we propose the assessment of potential beneficial effects of the antibiotics vancomycin and metronidazole on liver biochemistries, liver related symptoms and Mayo risk score in patients with PSC. The patients will be randomized into four groups of ten patients: one group will receive low dose vancomycin, one group will receive high dose vancomycin, one group will receive low dose metronidazole and
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Erlotinib for Chemoprevention in Trisomy 7 Positive Primary Sclerosing Cholangitis (PSC)
Primary sclerosing cholangitis (PSC) is a chronic inflammatory condition of the bile ducts of unknown etiology. It is characterized by diffuse inflammation and stricturing of the entire biliary tree, eventually resulting in cirrhosis of the liver.
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P.R.O.G.R.E.S.S.: PSC Resource Of Genetic Risk, Environment and Synergy Studies
This research study is being done to unravel the genetic predisposition to primary sclerosing cholangitis (PSC). Evidence indicates that the inherited genetic material passed from parents to their children as well as environmental factors contribute to the development of PSC.
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